5GUE

Crystal structure of CotB2 (GGSPP/Mg2+-Bound Form) from Streptomyces melanosporofaciens

Summary for 5GUE

• Entry DOI: 10.2210/pdb5gue/pdb
• Related: 5GUC
• Descriptor: Cyclooctat-9-en-7-ol synthase, phosphonooxy-[(10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]sulfanyl-phosphinic acid, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: terpene cyclase fold, diterpene cyclase, lyase, biosynthetic protein
• Biological source: Streptomyces melanosporofaciens
• Total number of polymer chains: 4
• Total formula weight: 154731.77

Authors

Tomita, T.,Kim, S.-Y.,Ozaki, T.,Yoshida, A.,Kuzuyama, T.,Nishiyama, M. (deposition date: 2016-08-28, release date: 2017-06-07, Last modification date: 2023-11-08)

• Primary citation: Tomita, T.,Kim, S.-Y.,Teramoto, K.,Meguro, A.,Ozaki, T.,Yoshida, A.,Motoyoshi, Y.,Mori, N.,Ishigami, K.,Watanabe, H.,Nishiyama, M.,Kuzuyama, T.; Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol; ACS Chem. Biol., 12:1621-1628, 2017; PubMed: 28463490; DOI: 10.1021/acschembio.7b00154

Experimental method

X-RAY DIFFRACTION (1.8 Å)