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PDB: 204 件

5ESP
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BU of 5esp by Molmil
Crystal Structure of LAGLIDADG Meganuclease I-PanMI with coordinated Calcium ions
分子名称: CALCIUM ION, DNA (27-MER), GLYCEROL, ...
著者Hallinan, J.P, Stoddard, B.L.
登録日2015-11-16
公開日2016-03-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.995 Å)
主引用文献Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
6M9G
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BU of 6m9g by Molmil
BbvCI B2 dimer with Ta6Br14 clusters
分子名称: 1,2-ETHANEDIOL, ACETATE ION, BROMIDE ION, ...
著者Shen, B.W, Stoddard, B.L.
登録日2018-08-23
公開日2018-11-14
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI.
Nucleic Acids Res., 47, 2019
6MAG
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BU of 6mag by Molmil
native BbvCI B2 dimer in space group C222
分子名称: ACETATE ION, BbvCI endonuclease subunit 2, GLYCEROL, ...
著者Shen, B.W, Stoddard, B.L.
登録日2018-08-27
公開日2018-11-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI.
Nucleic Acids Res., 47, 2019
7SQ5
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BU of 7sq5 by Molmil
Designed trefoil knot protein, variant 3
分子名称: Designed trefoil knot protein, variant 3, SODIUM ION
著者Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P.
登録日2021-11-04
公開日2022-11-09
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.205 Å)
主引用文献De novo design of knotted tandem repeat proteins.
Nat Commun, 14, 2023
7RDR
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BU of 7rdr by Molmil
Circular tandem repeat protein with novel repeat topology and enhanced subunit contact surfaces
分子名称: Circular tendon repeat protein
著者Shen, B.W, Stoddard, B.L.
登録日2021-07-10
公開日2021-09-01
最終更新日2021-11-17
実験手法ELECTRON MICROSCOPY (6.5 Å)
主引用文献Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces.
Commun Biol, 4, 2021
7UNJ
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BU of 7unj by Molmil
De novo designed chlorophyll dimer protein with Zn pheophorbide a methyl ester matching geometry of purple bacterial special pair, SP1-ZnPPaM
分子名称: 1,2-ETHANEDIOL, SP1-ZnPPaM designed chlorophyll dimer protein, SULFATE ION, ...
著者Kennedy, M.A, Stoddard, B.L, Ennist, N.M.
登録日2022-04-11
公開日2023-04-19
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献De novo design of proteins housing excitonically coupled chlorophyll special pairs.
Nat.Chem.Biol., 2024
7UNH
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BU of 7unh by Molmil
De novo designed chlorophyll dimer protein in apo state, SP2
分子名称: 1,2-ETHANEDIOL, SP2 designed chlorophyll dimer protein
著者Kennedy, M.A, Stoddard, B.L, Ennist, N.M.
登録日2022-04-11
公開日2023-04-19
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献De novo design of proteins housing excitonically coupled chlorophyll special pairs.
Nat.Chem.Biol., 2024
7UNI
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BU of 7uni by Molmil
De novo designed chlorophyll dimer protein with Zn pheophorbide a methyl ester, SP2-ZnPPaM
分子名称: 1,2-ETHANEDIOL, PHOSPHATE ION, SP2-ZnPPaM designed chlorophyll dimer protein, ...
著者Kennedy, M.A, Stoddard, B.L, Ennist, N.M.
登録日2022-04-11
公開日2023-04-19
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献De novo design of proteins housing excitonically coupled chlorophyll special pairs.
Nat.Chem.Biol., 2024
4LQ0
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BU of 4lq0 by Molmil
Crystal structure of the I-LtrWI LAGLIDADG homing endonuclease bound to target DNA.
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
著者Chik, J, Shen, B, Stoddard, B.
登録日2013-07-16
公開日2014-07-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Structural Comparisons of LAGLIDADG Homing Endonucleases.
To be Published
1U3E
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BU of 1u3e by Molmil
DNA binding and cleavage by the HNH homing endonuclease I-HmuI
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 36-MER, ...
著者Shen, B.W, Landthaler, M, Shub, D.A, Stoddard, B.L.
登録日2004-07-21
公開日2004-08-31
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献DNA Binding and Cleavage by the HNH Homing Endonuclease I-HmuI.
J.Mol.Biol., 342, 2004
301D
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BU of 301d by Molmil
CAPTURING THE STRUCTURE OF A CATALYTIC RNA INTERMEDIATE: RNA HAMMERHEAD RIBOZYME, MG(II)-SOAKED
分子名称: MAGNESIUM ION, RNA HAMMERHEAD RIBOZYME
著者Scott, W.G, Murray, J.B, Arnold, J.R.P, Stoddard, B.L, Klug, A.
登録日1996-12-14
公開日1997-01-24
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Capturing the structure of a catalytic RNA intermediate: the hammerhead ribozyme.
Science, 274, 1996
299D
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BU of 299d by Molmil
CAPTURING THE STRUCTURE OF A CATALYTIC RNA INTERMEDIATE: THE HAMMERHEAD RIBOZYME
分子名称: RNA HAMMERHEAD RIBOZYME
著者Scott, W.G, Murray, J.B, Arnold, J.R.P, Stoddard, B.L, Klug, A.
登録日1996-12-14
公開日1997-01-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Capturing the structure of a catalytic RNA intermediate: the hammerhead ribozyme.
Science, 274, 1996
8EIL
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BU of 8eil by Molmil
C-Terminal Domain of BrxL from Acinetobacter BREX type I phage restriction system
分子名称: MALONIC ACID, Protease Lon-related BREX system protein BrxL, SUCCINIC ACID
著者Doyle, L.A, Stoddard, B.L, Kaiser, B.
登録日2022-09-15
公開日2023-02-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor.
Nucleic Acids Res., 51, 2023
6MAF
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BU of 6maf by Molmil
native BbvCI A2B2 tetramer at low resolution
分子名称: BbvCI endonuclease subunit 1, BbvCI endonuclease subunit 2
著者Shen, B.W, Stoddard, B.L.
登録日2018-08-27
公開日2018-11-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.79 Å)
主引用文献Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI.
Nucleic Acids Res., 47, 2019
5JSB
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BU of 5jsb by Molmil
Crystal structure of Mcl1-inhibitor complex
分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 inhibitor
著者Shen, B.W, Stoddard, B.L.
登録日2016-05-07
公開日2016-11-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.
Elife, 5, 2016
4LOX
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BU of 4lox by Molmil
Crystal structure of the I-SmaMI LAGLIDADG homing endonuclease bound to cleaved DNA
分子名称: DNA (5'-D(*CP*GP*TP*AP*CP*AP*CP*CP*TP*GP*AP*TP*AP*A)-3'), DNA (5'-D(*GP*GP*TP*AP*TP*CP*CP*TP*CP*CP*AP*TP*TP*AP*T)-3'), DNA (5'-D(P*CP*AP*GP*GP*TP*GP*TP*AP*CP*G)-3'), ...
著者Chik, J, Shen, B, Stoddard, B.
登録日2013-07-14
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Crystal structure of a LAGLIDADG endonuclease from the Sordaria Macrospore.
To be Published
6UW0
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BU of 6uw0 by Molmil
Engineered variant of I-OnuI meganuclease with improved thermostability and fully altered specificity targeting cholera toxin A subunit
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DNA (27-MER), ...
著者Werther, R, Stoddard, B.L.
登録日2019-11-04
公開日2019-12-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
8EMC
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BU of 8emc by Molmil
CryoEM characterization of BrxL -- a unique AAA+ phage restriction Factor.
分子名称: Protease Lon-related BREX system protein BrxL
著者Shen, B.W, Stoddard, B.L.
登録日2022-09-27
公開日2023-02-01
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor.
Nucleic Acids Res., 51, 2023
8EMH
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BU of 8emh by Molmil
CryoEM characterization of a unique AAA+ BrxL phage restriction factor
分子名称: DNA (63-MER), DNA (64-MER), Protease Lon-related BREX system protein BrxL
著者Shen, B.W, Stoddard, B.L.
登録日2022-09-27
公開日2023-02-01
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.63 Å)
主引用文献Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor.
Nucleic Acids Res., 51, 2023
5THG
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BU of 5thg by Molmil
Engineered variant of I-OnuI meganuclease targeting the HIV CCR5 gene; harbors 43 point mutations relative to wild-type I-OnuI
分子名称: CALCIUM ION, DNA (29-MER), GLYCEROL, ...
著者Hallinan, J.P, Stoddard, B.L.
登録日2016-09-29
公開日2017-05-03
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.106 Å)
主引用文献The structural basis of altered gene specificity resulting from meganuclease and MegaTAL engineering
to be published
300D
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BU of 300d by Molmil
CAPTURING THE STRUCTURE OF A CATALYTIC RNA INTERMEDIATE: RNA HAMMERHEAD RIBOZYME, MN(II)-SOAKED
分子名称: MANGANESE (II) ION, RNA HAMMERHEAD RIBOZYME
著者Scott, W.G, Murray, J.B, Arnold, J.R.P, Stoddard, B.L, Klug, A.
登録日1996-12-14
公開日1997-01-24
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Capturing the structure of a catalytic RNA intermediate: the hammerhead ribozyme.
Science, 274, 1996
1MOW
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BU of 1mow by Molmil
E-DreI
分子名称: 5'-D(*CP*CP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*AP*GP*TP*TP*CP*CP*GP*GP*CP*G)-3', 5'-D(*CP*GP*CP*CP*GP*GP*AP*AP*CP*TP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP*GP*G)-3', GLYCEROL, ...
著者Chevalier, B.S, Kortemme, T, Chadsey, M.S, Baker, D, Monnat Jr, R.J, Stoddard, B.L.
登録日2002-09-10
公開日2002-11-29
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Design, Activity and Structure of a Highly Specific Artificial Endonuclease
Mol.Cell, 10, 2002
4IWW
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BU of 4iww by Molmil
Computational Design of an Unnatural Amino Acid Metalloprotein with Atomic Level Accuracy
分子名称: COBALT (II) ION, SULFATE ION, Unnatural Amino Acid Mediated Metalloprotein
著者Mills, J, Bolduc, J, Khare, S, Stoddard, B, Baker, D.
登録日2013-01-24
公開日2013-08-21
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Computational design of an unnatural amino Acid dependent metalloprotein with atomic level accuracy.
J.Am.Chem.Soc., 135, 2013
4OYD
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BU of 4oyd by Molmil
Crystal structure of a computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein
分子名称: 1,2-ETHANEDIOL, Apoptosis regulator BHRF1, Computationally designed Inhibitor
著者Shen, B, Procko, E, Baker, D, Stoddard, B.
登録日2014-02-11
公開日2014-07-09
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A computationally designed inhibitor of an epstein-barr viral bcl-2 protein induces apoptosis in infected cells.
Cell, 157, 2014
3LDY
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BU of 3ldy by Molmil
An extraordinary mechanism of DNA perturbation exhibited by the rare-cutting HNH restriction endonuclease PacI
分子名称: CALCIUM ION, DNA (5'-D(*GP*AP*GP*GP*CP*TP*TP*A)-3'), DNA (5'-D(P*AP*TP*TP*AP*AP*GP*CP*CP*TP*C)-3'), ...
著者Shen, B.W, Heiter, D, Chan, S.-H, Xu, S.-Y, Wilson, G, Stoddard, B.L.
登録日2010-01-13
公開日2010-04-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI.
Structure, 18, 2010

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件を2024-07-24に公開中

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