5OCA
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![BU of 5oca by Molmil](/molmil-images/mine/5oca) | PCSK9:Fab Complex with Dextran Sulfate | Descriptor: | 2,3,4-tri-O-sulfo-beta-D-altropyranose-(1-6)-2,3-di-O-sulfo-alpha-L-glucopyranose, Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain, ... | Authors: | Thirup, S.S, Vilstrup, J.P. | Deposit date: | 2017-06-30 | Release date: | 2017-09-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Heparan sulfate proteoglycans present PCSK9 to the LDL receptor. Nat Commun, 8, 2017
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6EHO
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![BU of 6eho by Molmil](/molmil-images/mine/6eho) | Dimer of the Sortilin Vps10p domain at low pH | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sortilin, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Thirup, S.S, Quistgaard, E.H, Januliene, D, Andersen, J.L, Nielsen, J.A. | Deposit date: | 2017-09-14 | Release date: | 2017-12-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Acidic Environment Induces Dimerization and Ligand Binding Site Collapse in the Vps10p Domain of Sortilin. Structure, 25, 2017
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6QUB
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![BU of 6qub by Molmil](/molmil-images/mine/6qub) | Truncated beta-galactosidase III from Bifidobacterium bifidum in complex with galactose | Descriptor: | Beta-galactosidase, CALCIUM ION, beta-D-galactopyranose | Authors: | Thirup, S.S, Nielsen, J.A, Andersen, J.L, Alsarraf, H, Blaise, M. | Deposit date: | 2019-02-27 | Release date: | 2020-03-18 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Truncated beta-galactosidase III from Bifidobacterium bifidum To Be Published
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6QUC
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![BU of 6quc by Molmil](/molmil-images/mine/6quc) | Truncated beta-galactosidase III from Bifidobacterium bifidum | Descriptor: | Beta-galactosidase, CALCIUM ION, IMIDAZOLE | Authors: | Thirup, S.S, Nielsen, J.A, Andersen, J.L, Alsarraf, H, Blaise, M. | Deposit date: | 2019-02-27 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Truncated beta-galactosidase III from Bifidobacterium bifidum To Be Published
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6QUD
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![BU of 6qud by Molmil](/molmil-images/mine/6qud) | 2-deoxy-galactose reaction intermediate of a Truncated beta-galactosidase III from Bifidobacterium bifidum | Descriptor: | 2-deoxy-alpha-D-galactopyranose, Beta-galactosidase, CALCIUM ION | Authors: | Thirup, S.S, Nielsen, J.A, Andersen, J.L, Alsarraf, H, Blaise, M. | Deposit date: | 2019-02-27 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Truncated beta-galactosidase III from Bifidobacterium bifidum To Be Published
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4PC3
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![BU of 4pc3 by Molmil](/molmil-images/mine/4pc3) | Elongation factor Tu:Ts complex with partially bound GDP | Descriptor: | Elongation factor Ts, Elongation factor Tu 1, GLYCEROL, ... | Authors: | Thirup, S.S. | Deposit date: | 2014-04-14 | Release date: | 2015-05-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8313 Å) | Cite: | Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu. J.Struct.Biol., 191, 2015
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4PC7
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![BU of 4pc7 by Molmil](/molmil-images/mine/4pc7) | Elongation factor Tu:Ts complex in a near GTP conformation. | Descriptor: | (1S,2S,3E,5E,7E,10S,11S,12S)-12-[(2R,4E,6E,8Z,10R,12E,14E,16Z,18S,19Z)-10,18-DIHYDROXY-12,16,19-TRIMETHYL-11,22-DIOXOOX ACYCLODOCOSA-4,6,8,12,14,16,19-HEPTAEN-2-YL]-2,11-DIHYDROXY-1,10-DIMETHYL-9-OXOTRIDECA-3,5,7-TRIEN-1-YL 6-DEOXY-2,4-DI-O-METHYL-BETA-L-GALACTOPYRANOSIDE, Elongation factor Ts, Elongation factor Tu 1, ... | Authors: | Thirup, S.S. | Deposit date: | 2014-04-14 | Release date: | 2015-05-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.6003 Å) | Cite: | Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu. J.Struct.Biol., 191, 2015
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4PC1
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![BU of 4pc1 by Molmil](/molmil-images/mine/4pc1) | Elongation Factor Tu:Ts complex with a bound phosphate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Elongation factor Ts, Elongation factor Tu, ... | Authors: | Thirup, S.S. | Deposit date: | 2014-04-14 | Release date: | 2015-05-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu. J.Struct.Biol., 191, 2015
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4PC6
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![BU of 4pc6 by Molmil](/molmil-images/mine/4pc6) | Elongation factor Tu:Ts complex with bound GDPNP | Descriptor: | Elongation factor Ts, Elongation factor Tu, GLYCEROL, ... | Authors: | Thirup, S.S. | Deposit date: | 2014-04-14 | Release date: | 2015-05-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu. J.Struct.Biol., 191, 2015
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4PC2
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![BU of 4pc2 by Molmil](/molmil-images/mine/4pc2) | Elongation factor Tu:Ts complex with a bound GDP | Descriptor: | CHLORIDE ION, Elongation factor Ts, Elongation factor Tu, ... | Authors: | Thirup, S.S. | Deposit date: | 2014-04-14 | Release date: | 2015-05-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1999 Å) | Cite: | Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu. J.Struct.Biol., 191, 2015
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8HNR
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![BU of 8hnr by Molmil](/molmil-images/mine/8hnr) | Molecular structure of Kunitz-type trypsin inhibitor from seeds of Albizia procera | Descriptor: | Kunitz-type trypsin inhibitor | Authors: | Mehmood, S, Thirup, S.S, Saeed, A, Rafiq, M, Khaliq, B, Akrem, A. | Deposit date: | 2022-12-08 | Release date: | 2023-02-01 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Molecular structure of Kunitz-type trypsin inhibitor from seeds of Albizia procera To Be Published
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1TTT
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![BU of 1ttt by Molmil](/molmil-images/mine/1ttt) | Phe-tRNA, elongation factoR EF-TU:GDPNP ternary complex | Descriptor: | MAGNESIUM ION, OF ELONGATION FACTOR TU (EF-TU), PHENYLALANINE, ... | Authors: | Nissen, P, Kjeldgaard, M, Thirup, S, Polekhina, G, Reshetnikova, L, Clark, B.F.C, Nyborg, J. | Deposit date: | 1995-11-16 | Release date: | 1996-12-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog. Science, 270, 1995
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1TUI
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![BU of 1tui by Molmil](/molmil-images/mine/1tui) | INTACT ELONGATION FACTOR TU IN COMPLEX WITH GDP | Descriptor: | ELONGATION FACTOR TU, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Polekhina, G, Thirup, S, Kjeldgaard, M, Nissen, P, Lippmann, C, Nyborg, J. | Deposit date: | 1996-05-23 | Release date: | 1997-06-05 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Helix unwinding in the effector region of elongation factor EF-Tu-GDP. Structure, 4, 1996
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3KFU
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![BU of 3kfu by Molmil](/molmil-images/mine/3kfu) | Crystal structure of the transamidosome | Descriptor: | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Glutamyl-tRNA(Gln) amidotransferase subunit A, Glutamyl-tRNA(Gln) amidotransferase subunit C, ... | Authors: | Blaise, M, Bailly, M, Frechin, M, Thirup, S, Becker, H.D, Kern, D. | Deposit date: | 2009-10-28 | Release date: | 2010-08-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of a transfer-ribonucleoprotein particle that promotes asparagine formation. Embo J., 29, 2010
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1ETU
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![BU of 1etu by Molmil](/molmil-images/mine/1etu) | STRUCTURAL DETAILS OF THE BINDING OF GUANOSINE DIPHOSPHATE TO ELONGATION FACTOR TU FROM E. COLI AS STUDIED BY X-RAY CRYSTALLOGRAPHY | Descriptor: | ELONGATION FACTOR TU, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Clark, B.F.C, Lacour, T.F.M, Kjeldgaard, M, Morikawa, K, Nyborg, J, Rubin, R, Thirup, S. | Deposit date: | 1988-01-15 | Release date: | 1988-07-16 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography. EMBO J., 4, 1985
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4XCM
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![BU of 4xcm by Molmil](/molmil-images/mine/4xcm) | Crystal structure of the putative NlpC/P60 D,L endopeptidase from T. thermophilus | Descriptor: | Cell wall-binding endopeptidase-related protein | Authors: | Wong, J, Midtgaard, S, Gysel, K, Thygesen, M.B, Sorensen, K.K, Jensen, K.J, Stougaard, J, Thirup, S, Blaise, M. | Deposit date: | 2014-12-18 | Release date: | 2015-01-14 | Last modified: | 2018-01-17 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase. Acta Crystallogr.,Sect.D, 71, 2015
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5MRI
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![BU of 5mri by Molmil](/molmil-images/mine/5mri) | Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with Triazolone 18 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sortilin, ... | Authors: | Andersen, J.L, Strandbygaard, D, Thirup, S. | Deposit date: | 2016-12-23 | Release date: | 2017-05-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin. Bioorg. Med. Chem. Lett., 27, 2017
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5MRH
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![BU of 5mrh by Molmil](/molmil-images/mine/5mrh) | Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with Triazolone 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(3-methylbutyl)-4~{H}-1,2,3-triazol-5-one, Sortilin, ... | Authors: | Andersen, J.L, Strandbygaard, D, Thirup, S. | Deposit date: | 2016-12-23 | Release date: | 2017-05-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin. Bioorg. Med. Chem. Lett., 27, 2017
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6EZE
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![BU of 6eze by Molmil](/molmil-images/mine/6eze) | The open conformation of E.coli Elongation Factor Tu in complex with GDPNP. | Descriptor: | DI(HYDROXYETHYL)ETHER, Elongation factor Tu 2, GLYCEROL, ... | Authors: | Johansen, J.S, Blaise, M, Thirup, S.S. | Deposit date: | 2017-11-15 | Release date: | 2018-08-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form. Nucleic Acids Res., 46, 2018
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6TPU
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![BU of 6tpu by Molmil](/molmil-images/mine/6tpu) | Crystal structures of FNIII domain three and four of the human leucocyte common antigen-related protein, LAR | Descriptor: | CHLORIDE ION, Receptor-type tyrosine-protein phosphatase F | Authors: | Vilstrup, J.P, Thirup, S.S, Simonsen, A, Birkefeldt, T, Strandbygaard, D. | Deposit date: | 2019-12-14 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal and solution structures of fragments of the human leucocyte common antigen-related protein. Acta Crystallogr D Struct Biol, 76, 2020
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6TPT
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![BU of 6tpt by Molmil](/molmil-images/mine/6tpt) | Crystal structures of FNIII domain three and four of the human leucocyte common antigen-related protein, LAR | Descriptor: | Receptor-type tyrosine-protein phosphatase F | Authors: | Vilstrup, J.P, Thirup, S.S, Simonsen, A, Birkefeldt, T, Strandbygaard, D. | Deposit date: | 2019-12-14 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal and solution structures of fragments of the human leucocyte common antigen-related protein. Acta Crystallogr D Struct Biol, 76, 2020
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6TPV
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![BU of 6tpv by Molmil](/molmil-images/mine/6tpv) | Crystal structures of FNIII domain one and two of the human leucocyte common antigen-related protein, LAR | Descriptor: | IMIDAZOLE, Receptor-type tyrosine-protein phosphatase F | Authors: | Vilstrup, J.P, Thirup, S.S, Simonsen, A, Birkefeldt, T, Strandbygaard, D. | Deposit date: | 2019-12-14 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal and solution structures of fragments of the human leucocyte common antigen-related protein. Acta Crystallogr D Struct Biol, 76, 2020
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6TPW
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![BU of 6tpw by Molmil](/molmil-images/mine/6tpw) | Crystal structures of FNIII domain one through four of the human leucocyte common antigen-related protein ( LAR) | Descriptor: | Receptor-type tyrosine-protein phosphatase F, SULFATE ION | Authors: | Vilstrup, J.P, Thirup, S.S, Simonsen, A, Birkefeldt, T, Strandbygaard, D. | Deposit date: | 2019-12-14 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal and solution structures of fragments of the human leucocyte common antigen-related protein. Acta Crystallogr D Struct Biol, 76, 2020
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4A1K
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![BU of 4a1k by Molmil](/molmil-images/mine/4a1k) | Ykud L,D-transpeptidase | Descriptor: | PUTATIVE L, D-TRANSPEPTIDASE YKUD, SULFATE ION | Authors: | Blaise, M, Fuglsang Midtgaard, S, Roi Midtgaard, S, Boesen, T, Thirup, S. | Deposit date: | 2011-09-15 | Release date: | 2012-09-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structures of Three New Crystal Forms of the Ykud L,D-Transpeptidase from B. Subtilis. To be Published
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4A1J
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![BU of 4a1j by Molmil](/molmil-images/mine/4a1j) | Ykud L,D-transpeptidase from B.subtilis | Descriptor: | PUTATIVE L, D-TRANSPEPTIDASE YKUD, SULFATE ION | Authors: | Blaise, M, Fuglsang Midtgaard, S, Roi Midtgaard, S, Boesen, T, Thirup, S. | Deposit date: | 2011-09-15 | Release date: | 2012-09-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of Ykud To be Published
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