3PJC
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![BU of 3pjc by Molmil](/molmil-images/mine/3pjc) | Crystal structure of JAK3 complexed with a potent ATP site inhibitor showing high selectivity within the Janus kinase family | Descriptor: | 3-(1H-indol-3-yl)-4-[2-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrrole-2,5-dione, Tyrosine-protein kinase JAK3 | Authors: | Tavares, G.A, Thoma, G, Zerwes, H.-G, Kroemer, M. | Deposit date: | 2010-11-09 | Release date: | 2010-12-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Identification of a Potent Janus Kinase 3 Inhibitor with High Selectivity within the Janus Kinase Family. J.Med.Chem., 54, 2011
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3KRR
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![BU of 3krr by Molmil](/molmil-images/mine/3krr) | Crystal Structure of JAK2 complexed with a potent quinoxaline ATP site inhibitor | Descriptor: | 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1H-pyrazol-4-yl)quinoxaline, Tyrosine-protein kinase JAK2 | Authors: | Tavares, G.A, Gerspacher, M, Kroemer, M, Scheufler, C. | Deposit date: | 2009-11-19 | Release date: | 2010-07-21 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805 Mol.Cancer Ther., 9, 2010
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3LPB
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![BU of 3lpb by Molmil](/molmil-images/mine/3lpb) | Crystal structure of Jak2 complexed with a potent 2,8-diaryl-quinoxaline inhibitor | Descriptor: | N-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide, Tyrosine-protein kinase JAK2 | Authors: | Tavares, G.A, Pissot-Soldermann, C, Gerspacher, M, Furet, P, Kroemer, M. | Deposit date: | 2010-02-05 | Release date: | 2010-04-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors Bioorg.Med.Chem.Lett., 20, 2010
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1JXO
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![BU of 1jxo by Molmil](/molmil-images/mine/1jxo) | |
1JXM
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![BU of 1jxm by Molmil](/molmil-images/mine/1jxm) | CRYSTAL STRUCTURE OF THE GMP BOUND SH3-HOOK-GK FRAGMENT OF PSD-95 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, GUANIDINE, GUANOSINE-5'-MONOPHOSPHATE, ... | Authors: | Tavares, G.A, Panepucci, E.H, Brunger, A.T. | Deposit date: | 2001-09-07 | Release date: | 2002-01-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95. Mol.Cell, 8, 2001
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1EW3
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![BU of 1ew3 by Molmil](/molmil-images/mine/1ew3) | CRYSTAL STRUCTURE OF THE MAJOR HORSE ALLERGEN EQU C 1 | Descriptor: | ALLERGEN EQU C 1 | Authors: | Lascombe, M.B, Gregoire, C, Poncet, P, Tavares, G.A, Rosinski-Chupin, I, Rabillon, J, Goubran-Botros, H, Mazie, J.C, David, B, Alzari, P.M. | Deposit date: | 2000-04-21 | Release date: | 2000-05-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes. J.Biol.Chem., 275, 2000
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3UGC
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![BU of 3ugc by Molmil](/molmil-images/mine/3ugc) | Structural basis of Jak2 inhibition by the type II inhibtor NVP-BBT594 | Descriptor: | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1H-indole-1-carboxamide, MALONATE ION, Tyrosine-protein kinase JAK2 | Authors: | Scheufler, C, Tavares, G.A, Manley, P.W, Pissot-Soldermann, C, Kroemer, M. | Deposit date: | 2011-11-02 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent. Cancer Discov, 2, 2012
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1MZ5
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![BU of 1mz5 by Molmil](/molmil-images/mine/1mz5) | Trypanosoma rangeli sialidase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, sialidase | Authors: | Buschiazzo, A, Tavares, G.A, Campetella, O, Spinelli, S, Cremona, M.L, Paris, G, Amaya, M.F, Frasch, A.C.C, Alzari, P.M. | Deposit date: | 2002-10-05 | Release date: | 2002-10-16 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of sialyltransferase activity in trypanosomal sialidases Embo J., 19, 2000
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1MZ6
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![BU of 1mz6 by Molmil](/molmil-images/mine/1mz6) | Trypanosoma rangeli sialidase in complex with the inhibitor DANA | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, sialidase | Authors: | Buschiazzo, A, Tavares, G.A, Campetella, O, Spinelli, S, Cremona, M.L, Paris, G, Amaya, M.F, Frasch, A.C.C, Alzari, P.M. | Deposit date: | 2002-10-05 | Release date: | 2002-10-16 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis of sialyltransferase activity in trypanosomal sialidases Embo J., 19, 2000
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