2G37
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![BU of 2g37 by Molmil](/molmil-images/mine/2g37) | Structure of Thermus thermophilus L-proline dehydrogenase | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase | Authors: | Tanner, J.J, White, T.A. | Deposit date: | 2006-02-17 | Release date: | 2007-02-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and Kinetics of Monofunctional Proline Dehydrogenase from Thermus thermophilus. J.Biol.Chem., 282, 2007
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6KP7
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6KP2
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6KOT
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6KPR
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1TJ2
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![BU of 1tj2 by Molmil](/molmil-images/mine/1tj2) | Crystal structure of E. coli PutA proline dehydrogenase domain (residues 86-669) complexed with acetate | Descriptor: | ACETATE ION, Bifunctional putA protein, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Tanner, J.J, Zhang, M, White, T.A, Schuermann, J.P, Baban, B.A, Becker, D.F. | Deposit date: | 2004-06-03 | Release date: | 2004-10-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors Biochemistry, 43, 2004
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2J4Y
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![BU of 2j4y by Molmil](/molmil-images/mine/2j4y) | Crystal structure of a rhodopsin stabilizing mutant expressed in mammalian cells | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RETINAL, RHODOPSIN | Authors: | Standfuss, J, Xie, G, Edwards, P.C, Burghammer, M, Oprian, D.D, Schertler, G.F.X. | Deposit date: | 2006-09-07 | Release date: | 2007-09-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal Structure of a Thermally Stable Rhodopsin Mutant. J.Mol.Biol., 372, 2007
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4E3X
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![BU of 4e3x by Molmil](/molmil-images/mine/4e3x) | Crystal Structure of Mus musculus 1-pyrroline-5-carboxylate dehydrogenase cryoprotected in proline | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE, Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, ... | Authors: | Tanner, J.J, Pemberton, T.A. | Deposit date: | 2012-03-10 | Release date: | 2012-07-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | Proline: Mother Nature's cryoprotectant applied to protein crystallography. Acta Crystallogr.,Sect.D, 68, 2012
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1I8M
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![BU of 1i8m by Molmil](/molmil-images/mine/1i8m) | CRYSTAL STRUCTURE OF A RECOMBINANT ANTI-SINGLE-STRANDED DNA ANTIBODY FRAGMENT COMPLEXED WITH DT5 | Descriptor: | 5'-D(*TP*TP*TP*TP*T)-3', 5'-D(P*TP*T)-3', ANTIBODY HEAVY CHAIN FAB, ... | Authors: | Tanner, J.J, Komissarov, A.A, Deutscher, S.L. | Deposit date: | 2001-03-14 | Release date: | 2001-12-07 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of an Antigen-Binding Fragment Bound to Single-Stranded DNA J.Mol.Biol., 314, 2001
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1S3P
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2X72
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![BU of 2x72 by Molmil](/molmil-images/mine/2x72) | CRYSTAL STRUCTURE OF THE CONSTITUTIVELY ACTIVE E113Q,D2C,D282C RHODOPSIN MUTANT WITH BOUND GALPHACT PEPTIDE. | Descriptor: | 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, ACETATE ION, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ... | Authors: | Standfuss, J, Edwards, P.C, Dantona, A, Fransen, M, Xie, G, Oprian, D.D, Schertler, G.F.X. | Deposit date: | 2010-02-22 | Release date: | 2011-03-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The Structural Basis of Agonist Induced Activation in Constitutively Active Rhodopsin Nature, 471, 2011
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1TJ1
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![BU of 1tj1 by Molmil](/molmil-images/mine/1tj1) | Crystal structure of E. coli PutA proline dehydrogenase domain (residues 86-669) complexed with L-lactate | Descriptor: | (2S)-2-HYDROXYPROPANOIC ACID, Bifunctional putA protein, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Tanner, J.J, Zhang, M, White, T.A, Schuermann, J.P, Baban, B.A, Becker, D.F. | Deposit date: | 2004-06-03 | Release date: | 2004-10-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors Biochemistry, 43, 2004
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4E3W
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2BKJ
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1TJ0
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![BU of 1tj0 by Molmil](/molmil-images/mine/1tj0) | Crystal structure of E. coli PutA proline dehydrogenase domain (residues 86-669) co-crystallized with L-lactate | Descriptor: | (2S)-2-HYDROXYPROPANOIC ACID, Bifunctional putA protein, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Tanner, J.J, Zhang, M, White, T.A, Schuermann, J.P, Baban, B.A, Becker, D.F. | Deposit date: | 2004-06-02 | Release date: | 2004-10-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors Biochemistry, 43, 2004
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1TIW
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![BU of 1tiw by Molmil](/molmil-images/mine/1tiw) | Crystal structure of E. coli PutA proline dehydrogenase domain (residues 86-669) complexed with L-Tetrahydro-2-furoic acid | Descriptor: | Bifunctional putA protein, FLAVIN-ADENINE DINUCLEOTIDE, TETRAHYDROFURAN-2-CARBOXYLIC ACID | Authors: | Tanner, J.J, Zhang, M, White, T.A, Schuermann, J.P, Baban, B.A, Becker, D.F. | Deposit date: | 2004-06-02 | Release date: | 2004-10-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors Biochemistry, 43, 2004
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7F3Y
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![BU of 7f3y by Molmil](/molmil-images/mine/7f3y) | Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with methotrexate (MTX), NADPH and dUMP | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, GLYCEROL, ... | Authors: | Vanichtanankul, J, Tanramluk, D, Yuvaniyama, J, Yuthavong, Y. | Deposit date: | 2021-06-17 | Release date: | 2021-09-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.252 Å) | Cite: | MANORAA: A machine learning platform to guide protein-ligand design by anchors and influential distances. Structure, 30, 2022
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7F3Z
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![BU of 7f3z by Molmil](/molmil-images/mine/7f3z) | Double mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-K1, C59R+S108N) complexed with Trimethoprim (TOP), NADPH and dUMP | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, GLYCEROL, ... | Authors: | Vanichtanankul, J, Tanramluk, D, Chitnumsub, P, Yuvaniyama, J, Yuthavong, Y. | Deposit date: | 2021-06-17 | Release date: | 2021-09-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | MANORAA: A machine learning platform to guide protein-ligand design by anchors and influential distances. Structure, 30, 2022
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3RG9
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![BU of 3rg9 by Molmil](/molmil-images/mine/3rg9) | Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210 | Descriptor: | 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE, Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Vanichtanankul, J, Yuvaniyama, J, Yuthavong, Y. | Deposit date: | 2011-04-08 | Release date: | 2011-06-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Trypanosomal dihydrofolate reductase reveals natural antifolate resistance Acs Chem.Biol., 6, 2011
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4OE6
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![BU of 4oe6 by Molmil](/molmil-images/mine/4oe6) | Crystal Structure of Yeast ALDH4A1 | Descriptor: | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | Authors: | Tanner, J.J. | Deposit date: | 2014-01-11 | Release date: | 2014-02-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.951 Å) | Cite: | Structural Studies of Yeast Delta (1)-Pyrroline-5-carboxylate Dehydrogenase (ALDH4A1): Active Site Flexibility and Oligomeric State. Biochemistry, 53, 2014
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2FR4
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![BU of 2fr4 by Molmil](/molmil-images/mine/2fr4) | Structure of Fab DNA-1 complexed with a stem-loop DNA ligand | Descriptor: | 5'-D(*CP*TP*GP*CP*CP*TP*TP*CP*AP*G)-3', TETRAETHYLENE GLYCOL, antibody heavy chain FAB, ... | Authors: | Tanner, J.J, Ou, Z. | Deposit date: | 2006-01-18 | Release date: | 2007-01-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Impact of DNA hairpin folding energetics on antibody-ssDNA association. J.Mol.Biol., 374, 2007
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3QFX
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![BU of 3qfx by Molmil](/molmil-images/mine/3qfx) | Trypanosoma brucei dihydrofolate reductase pyrimethamine complex | Descriptor: | 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Vanichtanankul, J, Yuvaniyama, J, Taweechai, S, Chitnumsub, P, Kamchonwongpaisan, S, Yuthavong, Y. | Deposit date: | 2011-01-24 | Release date: | 2011-06-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Trypanosomal dihydrofolate reductase reveals natural antifolate resistance Acs Chem.Biol., 6, 2011
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5AMG
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4E3U
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7XI7
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![BU of 7xi7 by Molmil](/molmil-images/mine/7xi7) | Human dihydrofolate reductase complexed with P39 | Descriptor: | 6-hexyl-5-phenyl-pyrimidine-2,4-diamine, Dihydrofolate reductase, SULFATE ION | Authors: | Vanichtanankul, J, Saeyang, T, Kamchonwongpaisan, S, Yuvaniyama, J, Yuthavong, Y. | Deposit date: | 2022-04-12 | Release date: | 2022-06-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase. Acs Chem.Biol., 17, 2022
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