1YQJ
 
 | | Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor | | 分子名称: | 6((S)-3-BENZYLPIPERAZIN-1-YL)-3-(NAPHTHALEN-2-YL)-4-(PYRIDIN-4-YL)PYRAZINE, Mitogen-activated protein kinase 14, SULFATE ION | | 著者 | Tamayo, N, Liao, H, Goldberg, M, Syed, R, Li, V, Powers, D, Tudor, Y, Yu, V, Wong, M.L, Henkle, B, Middelton, S, Harvey, T, Jang, G, Hungate, R, Dominguez, C. | | 登録日 | 2005-02-01 | | 公開日 | 2005-04-26 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.
Bioorg.Med.Chem.Lett., 15, 2005
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9BS2
 | | Glycosylase MutY variant R149Q in complex with DNA containing d(8-oxo-G) paired with a product analog (THF) to 1.51 A resolution | | 分子名称: | ACETIC ACID, Adenine DNA glycosylase, CALCIUM ION, ... | | 著者 | Trasvina-Arenas, C.H, Tamayo, N, Lin, W.J, Demir, M, Fisher, A.J, David, S.S, Horvath, M.P. | | 登録日 | 2024-05-12 | | 公開日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Structural and functional profiling of MUTYH cancer-associated variants reveal an allosteric role for its
[4Fe-4S] cluster cofactor
To Be Published
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4MRO
 | | Human GKRP bound to AMG-5980 and S6P | | 分子名称: | 2-(4-{4-[(6-aminopyridin-3-yl)sulfonyl]piperazin-1-yl}phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... | | 著者 | St Jean, D.J, Ashton, K.S, Bartberger, M.D, Chen, J, Chmait, S, Cupples, R, Galbreath, E, Helmering, J, Jordan, S.R, Liu, L, Kunz, K, Michelsen, K, Nishimura, N, Pennington, L.D, Poon, S.F, Sivits, G, Stec, M.M, Tamayo, N, Van, G, Yang, K, Norman, M.H, Fotsch, C, LLoyd, D.J, Hale, C. | | 登録日 | 2013-09-17 | | 公開日 | 2014-05-07 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
J.Med.Chem., 57, 2014
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