3QTF
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![BU of 3qtf by Molmil](/molmil-images/mine/3qtf) | Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity | Descriptor: | (6S)-6,15,15,18-tetramethyl-17-oxo-2,3,4,5,6,7,14,15,16,17-decahydro-1H-8,12-(metheno)[1,4,9]triazacyclotetradecino[9,8-a]indole-9-carboxamide, DIMETHYL SULFOXIDE, Heat shock protein HSP 90-alpha | Authors: | Zapf, C.W, Bloom, J.D, McBean, J.L, Dushin, R.G, Nittoli, T, Ingalls, C, Sutherland, A.G, Sonye, J.P, Eid, C.N, Golas, J, Liu, H, Boschelli, F, Hu, Y, Vogan, E.M, Levin, J.I. | Deposit date: | 2011-02-22 | Release date: | 2011-04-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.5703 Å) | Cite: | Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity. Bioorg.Med.Chem.Lett., 21, 2011
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2ARQ
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![BU of 2arq by Molmil](/molmil-images/mine/2arq) | Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh | Descriptor: | 14-mer from Plasminogen activator inhibitor-2, Plasminogen activator inhibitor-2 | Authors: | Di Giusto, D.A, Sutherland, A.P, Jankova, L, Harrop, S.J, Curmi, P.M, King, G.C. | Deposit date: | 2005-08-21 | Release date: | 2006-07-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Plasminogen activator inhibitor-2 is highly tolerant to P8 residue substitution--implications for serpin mechanistic model and prediction of nsSNP activities J.Mol.Biol., 353, 2005
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2ARR
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![BU of 2arr by Molmil](/molmil-images/mine/2arr) | Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagmggvmtgr-oh | Descriptor: | 14-mer from Plasminogen activator inhibitor-2, Plasminogen activator inhibitor-2 | Authors: | Di Giusto, D.A, Sutherland, A.P, Jankova, L, Harrop, S.J, Curmi, P.M, King, G.C. | Deposit date: | 2005-08-21 | Release date: | 2006-07-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Plasminogen activator inhibitor-2 is highly tolerant to P8 residue substitution--implications for serpin mechanistic model and prediction of nsSNP activities J.Mol.Biol., 353, 2005
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2GKJ
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![BU of 2gkj by Molmil](/molmil-images/mine/2gkj) | Crystal structure of diaminopimelate epimerase in complex with an irreversible inhibitor DL-AZIDAP | Descriptor: | (2R,6S)-2,6-DIAMINO-2-METHYLHEPTANEDIOIC ACID, ACETIC ACID, Diaminopimelate epimerase | Authors: | Pillai, B, Cherney, M.M, Diaper, C.M, Sutherland, A, Blanchard, J.S, Vederas, J.C, James, M.N. | Deposit date: | 2006-04-02 | Release date: | 2006-05-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2GKE
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![BU of 2gke by Molmil](/molmil-images/mine/2gke) | Crystal structure of diaminopimelate epimerase in complex with an irreversible inhibitor LL-AziDAP | Descriptor: | (2S,6S)-2,6-DIAMINO-2-METHYLHEPTANEDIOIC ACID, ACETIC ACID, Diaminopimelate epimerase, ... | Authors: | Pillai, B, Cherney, M.M, Diaper, C.M, Sutherland, A, Blanchard, J.S, Vederas, J.C, James, M.N. | Deposit date: | 2006-04-01 | Release date: | 2006-05-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target. Proc.Natl.Acad.Sci.Usa, 103, 2006
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1S1S
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![BU of 1s1s by Molmil](/molmil-images/mine/1s1s) | Crystal Structure of ZipA in complex with indoloquinolizin 10b | Descriptor: | Cell division protein zipA, N-{3-[(12bS)-7-oxo-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-12(2H)-yl]propyl}propane-2-sulfonamide | Authors: | Jennings, L.D, Foreman, K.W, Rush III, T.S, Tsao, D.H, Mosyak, L, Li, Y, Sukhdeo, M.N, Ding, W, Dushin, E.G, Kenny, C.H, Moghazeh, S.L, Petersen, P.J, Ruzin, A.V, Tuckman, M, Sutherland, A.G. | Deposit date: | 2004-01-07 | Release date: | 2005-01-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction BIOORG.MED.CHEM.LETT., 14, 2004
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1F06
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![BU of 1f06 by Molmil](/molmil-images/mine/1f06) | THREE DIMENSIONAL STRUCTURE OF THE TERNARY COMPLEX OF CORYNEBACTERIUM GLUTAMICUM DIAMINOPIMELATE DEHYDROGENASE NADPH-L-2-AMINO-6-METHYLENE-PIMELATE | Descriptor: | L-2-AMINO-6-METHYLENE-PIMELIC ACID, MESO-DIAMINOPIMELATE D-DEHYDROGENASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Cirilli, M, Scapin, G, Sutherland, A, Caplan, J.F, Vederas, J.C, Blanchard, J.S. | Deposit date: | 2000-05-14 | Release date: | 2001-05-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The three-dimensional structure of the ternary complex of Corynebacterium glutamicum diaminopimelate dehydrogenase-NADPH-L-2-amino-6-methylene-pimelate. Protein Sci., 9, 2000
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1S1J
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![BU of 1s1j by Molmil](/molmil-images/mine/1s1j) | Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1 | Descriptor: | (12bS)-1,2,3,4,12,12b-hexahydroindolo[2,3-a]quinolizin-7(6H)-one, Cell division protein zipA | Authors: | Jenning, L.D, Foreman, K.W, Rush III, T.S, Tsao, D.H, Mosyak, L, Li, Y, Sukhdeo, M.N, Ding, W, Dushin, E.G, Kenney, C.H, Moghazeh, S.L, Peterson, P.J, Ruzin, A.V, Tuckman, M, Sutherland, A.G. | Deposit date: | 2004-01-06 | Release date: | 2004-05-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction Bioorg.Med.Chem.Lett., 14, 2004
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2Q9J
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![BU of 2q9j by Molmil](/molmil-images/mine/2q9j) | Crystal structure of the C217S mutant of diaminopimelate epimerase | Descriptor: | 1,2-ETHANEDIOL, Diaminopimelate epimerase, SULFATE ION | Authors: | Pillai, B, Cherney, M, Diaper, C.M, Sutherland, A, Blanchard, J.S, Vederas, J.C. | Deposit date: | 2007-06-12 | Release date: | 2007-10-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase. Biochem.Biophys.Res.Commun., 363, 2007
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2Q9H
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![BU of 2q9h by Molmil](/molmil-images/mine/2q9h) | Crystal structure of the C73S mutant of diaminopimelate epimerase | Descriptor: | ACETIC ACID, Diaminopimelate epimerase, L(+)-TARTARIC ACID | Authors: | Pillai, B, Cherney, M, Diaper, C.M, Sutherland, A, Blanchard, J.S, Vederas, J.C, James, M.N.G. | Deposit date: | 2007-06-12 | Release date: | 2007-10-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase. Biochem.Biophys.Res.Commun., 363, 2007
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