1S1S

Crystal Structure of ZipA in complex with indoloquinolizin 10b

Summary for 1S1S

Related1S1J
DescriptorCell division protein zipA, N-{3-[(12bS)-7-oxo-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-12(2H)-yl]propyl}propane-2-sulfonamide (3 entities in total)
Functional Keywordscell cycle
Biological sourceEscherichia coli
Cellular locationCell inner membrane; Single-pass type I membrane protein P77173
Total number of polymer chains2
Total molecular weight32672.51
Authors
Primary citation
JENNINGS, L.D.,FOREMAN, K.W.,RUSH III, T.S.,TSAO, D.H.,MOSYAK, L.,LI, Y.,SUKHDEO, M.N.,DING, W.,DUSHIN, E.G.,KENNY, C.H.,MOGHAZEH, S.L.,PETERSEN, P.J.,RUZIN, A.V.,TUCKMAN, M.,SUTHERLAND, A.G.
Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction
BIOORG.MED.CHEM.LETT., 14:1427-1431, 2004
PubMed: 15006376 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2004.01.028
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers171.8%4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution