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PDB: 7 件
6HEP
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BU of 6hep by Molmil
Crystal structure of human 14-3-3 beta in complex with CFTR R-domain peptide pS753-pS768
分子名称: 14-3-3 protein beta/alpha, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Cystic fibrosis transmembrane conductance regulator
著者Stevers, L.M, Ottmann, C, Brunsveld, L.
登録日2018-08-20
公開日2018-10-24
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions.
J. Am. Chem. Soc., 140, 2018
7QI1
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BU of 7qi1 by Molmil
Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424
分子名称: 14-3-3 protein theta, ARGININE, Cystic fibrosis transmembrane conductance regulator, ...
著者Stevers, L.M, Ottmann, C.
登録日2021-12-14
公開日2022-05-25
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR.
Nat Commun, 13, 2022
5MYC
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BU of 5myc by Molmil
Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS910
分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
著者Stevers, L.M, de Vries, R.M.J.M, Ottmann, C.
登録日2017-01-26
公開日2017-03-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.459 Å)
主引用文献Structural interface between LRRK2 and 14-3-3 protein.
Biochem. J., 474, 2017
5MY9
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BU of 5my9 by Molmil
Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS935
分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
著者Stevers, L.M, de Vries, R.M.J.M, Ottmann, C.
登録日2017-01-26
公開日2017-03-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.327 Å)
主引用文献Structural interface between LRRK2 and 14-3-3 protein.
Biochem. J., 474, 2017
5D2D
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BU of 5d2d by Molmil
Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768
分子名称: 14-3-3 protein zeta/delta, CHLORIDE ION, Cystic fibrosis transmembrane conductance regulator, ...
著者Stevers, L.M, Leysen, S.F.R, Ottmann, C.
登録日2015-08-05
公開日2016-03-16
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016
5D3F
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BU of 5d3f by Molmil
Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A
分子名称: 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, FUSICOCCIN
著者Stevers, L.M, Leysen, S.F.R, Ottmann, C.
登録日2015-08-06
公開日2016-03-16
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016
5D3E
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BU of 5d3e by Molmil
Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795
分子名称: 14-3-3 protein gamma, Cystic fibrosis transmembrane conductance regulator
著者Stevers, L.M, Leysen, S.F.R, Ottmann, C.
登録日2015-08-06
公開日2016-03-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016

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件を2024-07-03に公開中

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