8JB1
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5IJZ
| |
6IUN
| |
6IUM
| |
5IWQ
| |
8HRR
| |
8HRT
| |
8HRQ
| |
8HRS
| |
8HRP
| |
8HRO
| |
5X7N
| |
5X5U
| |
5YN3
| |
5X5T
| |
5EJ9
| EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2 min and isochorismate for 13 min | 分子名称: | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, FORMIC ACID, GLYCEROL, ... | 著者 | Song, H.G, Dong, C, Chen, Y.Z, Sun, Y.R, Guo, Z.H. | 登録日 | 2015-11-01 | 公開日 | 2016-06-01 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc., 138, 2016
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5EJ7
| EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 21 s | 分子名称: | (4S)-4-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3lambda~5~-thiazol-2-yl}-4-hydroxybutanoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, GLYCEROL, ... | 著者 | Song, H.G, Dong, C, Chen, Y.Z, Sun, Y.R, Guo, Z.H. | 登録日 | 2015-11-01 | 公開日 | 2016-06-01 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc., 138, 2016
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5EJM
| ThDP-Mn2+ complex of R413A variant of EcMenD soaked with 2-ketoglutarate for 35 min | 分子名称: | (4~{R})-4-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy)phosphoryl]oxyethyl]-1,3-thiazol-3-ium-2-yl]-4-oxidanyl-butanoic acid, 1,2-ETHANEDIOL, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, ... | 著者 | Song, H.G, Dong, C, Chen, Y.Z, Sun, Y.R, Guo, Z.H. | 登録日 | 2015-11-02 | 公開日 | 2016-11-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Two active site arginines are critical determinants of substrate binding and catalysis in MenD, a thiamine-dependent enzyme in menaquinone biosynthesis. Biochem. J., 2018
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5X7M
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5EJ4
| EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 15 min | 分子名称: | (4S)-4-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3lambda~5~-thiazol-2-yl}-4-hydroxybutanoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, FORMIC ACID, ... | 著者 | Song, H.G, Dong, C, Chen, Y.Z, Sun, Y.R, Guo, Z.H. | 登録日 | 2015-11-01 | 公開日 | 2016-06-01 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.773 Å) | 主引用文献 | A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc., 138, 2016
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5EJ5
| EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 1.5 h | 分子名称: | (4S)-4-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3lambda~5~-thiazol-2-yl}-4-hydroxybutanoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, GLYCEROL, ... | 著者 | Song, H.G, Dong, C, Chen, Y.Z, Sun, Y.R, Guo, Z.H. | 登録日 | 2015-11-01 | 公開日 | 2016-06-01 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc., 138, 2016
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1MBN
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5EJA
| EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2 min and soaked with isochorismate for 7 min | 分子名称: | (4S)-4-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3lambda~5~-thiazol-2-yl}-4-hydroxybutanoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, GLYCEROL, ... | 著者 | Song, H.G, Dong, C, Chen, Y.Z, Sun, Y.R, Guo, Z.H. | 登録日 | 2015-11-01 | 公開日 | 2016-06-01 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc., 138, 2016
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5EJ6
| EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2min then soaked with isochorismate for 2 min | 分子名称: | (4S)-4-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3lambda~5~-thiazol-2-yl}-4-hydroxybutanoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, MANGANESE (II) ION | 著者 | Song, H.G, Dong, C, Chen, Y.Z, Sun, Y.R, Guo, Z.H. | 登録日 | 2015-11-01 | 公開日 | 2016-06-01 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.243 Å) | 主引用文献 | A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc., 138, 2016
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5Z6T
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