6HRG
| Structure of Igni18, a novel metallo hydrolase from the hyperthermophilic archaeon Ignicoccus hospitalis KIN4/I | Descriptor: | PHOSPHATE ION, POTASSIUM ION, UPF0173 metal-dependent hydrolase Igni_1254, ... | Authors: | Smits, S.H, Streit, W.R, Jaeger, K.E, Hoeppner, A. | Deposit date: | 2018-09-26 | Release date: | 2019-10-09 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | A promiscuous ancestral enzyme ́s structure unveils protein variable regions of the highly diverse metallo-beta-lactamase family. Commun Biol, 4, 2021
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7PZE
| MademoiseLLE domain 2 of Rrm4 from Ustilago maydis | Descriptor: | Chromosome 8, whole genome shotgun sequence | Authors: | Devans, S, Schott-Verdugo, s, Muentjes, K, Olgeiser, L, Reiners, J, Schmitt, L, Hoeppner, A, Smits, S.H, Gohlke, H, Feldbruegge, M. | Deposit date: | 2021-10-12 | Release date: | 2022-06-15 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A MademoiseLLE domain binding platform links the key RNA transporter to endosomes. Plos Genet., 18, 2022
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4Y68
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8BYK
| The structure of MadC from Clostridium maddingley reveals new insights into class I lanthipeptide cyclases | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Knospe, C.V, Kamel, M, Spitz, O, Hoeppner, A, Galle, S, Reiners, J, Kedrov, A, Smits, S.H, Schmitt, L. | Deposit date: | 2022-12-13 | Release date: | 2023-02-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The structure of MadC from Clostridium maddingley reveals new insights into class I lanthipeptide cyclases. Front Microbiol, 13, 2022
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7QYF
| Structure of the transaminase PluriZyme variant (TR2E2) | Descriptor: | Aminotransferase TR2 | Authors: | Roda, S, Fernandez-Lopez, L, Benedens, M, Bollinger, A, Thies, S, Schumacher, J, Coscolin, C, Kazemi, M, Santiago, G, Gertzen, C.G, Gonzalez-Alfonso, J, Plou, F.J, Jaeger, K.E, Smits, S.H, Ferrer, M, Guallar, V. | Deposit date: | 2022-01-28 | Release date: | 2023-07-26 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | A Plurizyme with Transaminase and Hydrolase Activity Catalyzes Cascade Reactions. Angew Chem Int Ed Engl, 61, 2022
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7QX0
| Transaminase Structure of Plurienzyme (Tr2E2) in complex with PLP | Descriptor: | Aminotransferase TR2, PYRIDOXAL-5'-PHOSPHATE | Authors: | Roda, S, Fernandez-Lopez, L, Benedens, M, Bollinger, A, Thies, S, Schumacher, J, Coscolin, C, Kazemi, M, Santiago, G, Gertzen, C.G, Gonzalez-Alfonso, J, Plou, F.J, Jaeger, K.E, Smits, S.H, Ferrer, M, Guallar, V. | Deposit date: | 2022-01-26 | Release date: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | A Plurizyme with Transaminase and Hydrolase Activity Catalyzes Cascade Reactions. Angew Chem Int Ed Engl, 61, 2022
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7QYG
| Structure of the transaminase TR2 | Descriptor: | Aminotransferase TR2 | Authors: | Roda, S, Fernandez-Lopez, L, Benedens, M, Bollinger, A, Thies, S, Schumacher, J, Coscolin, C, Kazemi, M, Santiago, G, Gertzen, C.G, Gonzalez-Alfonso, J, Plou, F.J, Jaeger, K.E, Smits, S.H, Ferrer, M, Guallar, V. | Deposit date: | 2022-01-28 | Release date: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | A Plurizyme with Transaminase and Hydrolase Activity Catalyzes Cascade Reactions. Angew Chem Int Ed Engl, 61, 2022
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7QX3
| Structure of the transaminase TR2E2 with EOS | Descriptor: | 2-azanylethyl hydrogen sulfate, Aminotransferase TR2 | Authors: | Roda, S, Fernandez-Lopez, L, Benedens, M, Bollinger, A, Thies, S, Schumacher, J, Coscolin, C, Kazemi, M, Santiago, G, Gertzen, C.G, Gonzalez-Alfonso, J, Plou, F.J, Jaeger, K.E, Smits, S.H, Ferrer, M, Guallar, V. | Deposit date: | 2022-01-26 | Release date: | 2023-08-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | A Plurizyme with Transaminase and Hydrolase Activity Catalyzes Cascade Reactions. Angew.Chem.Int.Ed.Engl., 61, 2022
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6EYL
| Crystal structure of OpuBC in complex with carnitine | Descriptor: | CARNITINE, Osmotically activated L-carnitine/choline ABC transporter substrate-binding protein OpuCC | Authors: | Peherstorfer, S, Teichmann, L, Smits, S.H, Sschmitt, L, Bremer, E. | Deposit date: | 2017-11-13 | Release date: | 2018-11-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Reprogramming the substrate specificity of an ABC import system by a single amino acid substitution in its cognate ligand binding protein To Be Published
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6EYG
| Structure of a OpuBC mutant with bound Glycine betaine | Descriptor: | Osmotically activated L-carnitine/choline ABC transporter substrate-binding protein OpuCC, TRIMETHYL GLYCINE | Authors: | Peherstorfer, S, Teichmann, L, Smits, S.H, Schmitt, L, Bremer, E. | Deposit date: | 2017-11-13 | Release date: | 2018-11-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Structure of a OpuBC mutant with bound Glycine betaine To Be Published
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6EYQ
| Crystal structure of a mutated OpuBC in complex with choline | Descriptor: | CHOLINE ION, Choline-binding protein | Authors: | Peherstorfer, S, Teichmann, L, Smits, S.H, Schmitt, L, Bremer, E. | Deposit date: | 2017-11-13 | Release date: | 2018-11-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of a mutated OpuBC in complex with choline To Be Published
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6EYH
| Structure of a OpuBC mutant with bound Glycine betaine | Descriptor: | 3-(dimethyl-lambda~4~-sulfanyl)propanoic acid, Choline binding protein OpuBC | Authors: | Peherstorfer, S, Teichmann, L, Smits, S.H, Schmitt, L, Bremer, E. | Deposit date: | 2017-11-13 | Release date: | 2018-11-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of a OpuBC mutant with bound DMSP To Be Published
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3QHQ
| Structure of CRISPR-associated protein Csn2 | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Sag0897 family CRISPR-associated protein | Authors: | Ellinger, P, Arslan, Z, Wurm, R, Tschapek, B, Pfeffer, K, Wagner, R, Schmitt, L, Pul, U, Smits, S.H. | Deposit date: | 2011-01-26 | Release date: | 2012-02-01 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of CRISPR-associated protein Csn2 To be Published
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4MEE
| Crystal structure of the transport unit of the autotransporter AIDA-I from Escherichia coli | Descriptor: | Diffuse adherence adhesin | Authors: | Gawarzewski, I, Tschapek, B, Hoeppner, A, Smits, S.H, Jose, J, Schmitt, L. | Deposit date: | 2013-08-26 | Release date: | 2014-06-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the transport unit of the autotransporter adhesin involved in diffuse adherence from Escherichia coli. J.Struct.Biol., 187, 2014
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4MHU
| Crystal structure of EctD from S. alaskensis with bound Fe | Descriptor: | Ectoine hydroxylase, FE (III) ION, N-DODECYL-N,N-DIMETHYLGLYCINATE | Authors: | Widderich, N, Hoeppner, A, Pittelkow, M, Heider, J, Smits, S.H, Bremer, E. | Deposit date: | 2013-08-30 | Release date: | 2014-09-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Crystal structure of the ectoine hydroxylase, a snapshot of the active site. J.Biol.Chem., 289, 2014
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4MHR
| Crystal structure of EctD from S. alaskensis in its apoform | Descriptor: | Ectoine hydroxylase | Authors: | Widderich, N, Hoeppner, A, Pittelkow, M, Heider, J, Smits, S.H, Bremer, E. | Deposit date: | 2013-08-30 | Release date: | 2014-09-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the ectoine hydroxylase, a snapshot of the active site. J.Biol.Chem., 289, 2014
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4NMI
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5DCL
| Structure of a lantibiotic response regulator: N terminal domain of the nisin resistance regulator NsrR | Descriptor: | 1,2-ETHANEDIOL, PhoB family transcriptional regulator | Authors: | Khosa, S, Kleinschrodt, D, Hoeppner, A, Smits, S.H. | Deposit date: | 2015-08-24 | Release date: | 2016-03-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | Structure of the Response Regulator NsrR from Streptococcus agalactiae, Which Is Involved in Lantibiotic Resistance. Plos One, 11, 2016
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3MAM
| A molecular switch changes the low to the high affinity state in the substrate binding protein AfProX | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Osmoprotection protein (ProX), ... | Authors: | Tschapek, B, Pittelkow, M, Bremer, E, Schmitt, L, Smits, S.H. | Deposit date: | 2010-03-24 | Release date: | 2011-04-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Arg149 Is Involved in Switching the Low Affinity, Open State of the Binding Protein AfProX into Its High Affinity, Closed State. J.Mol.Biol., 411, 2011
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7PZJ
| Structure of a bacteroidetal polyethylene terephthalate (PET) esterase | Descriptor: | Lipase, POTASSIUM ION | Authors: | Zang, H, Dierkes, R, Perez-Garcia, P, Weigert, S, Sternagel, S, Hallam, S.J, Applegate, V, Schumacher, J, Schott, T, Pleiss, J, Almeida, A, Hoecker, B, Smits, S.H, Schmitz, R.A, Chow, J, Streit, W.R. | Deposit date: | 2021-10-12 | Release date: | 2022-03-02 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Bacteroidetes Aequorivita sp. and Kaistella jeonii Produce Promiscuous Esterases With PET-Hydrolyzing Activity. Front Microbiol, 12, 2021
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6RB3
| Structural basis for recognition and ring-cleavage of the Pseudomonas quinolone signal (PQS) by AqdC variant in complex with its substrate | Descriptor: | 2-heptylquinoline-3,4-diol, Putative dioxygenase (1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase) | Authors: | Wullich, S, Kobus, S, Smits, S.H, Fetzner, S. | Deposit date: | 2019-04-09 | Release date: | 2019-07-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for recognition and ring-cleavage of the Pseudomonas quinolone signal (PQS) by AqdC, a mycobacterial dioxygenase of the alpha / beta-hydrolase fold family. J.Struct.Biol., 207, 2019
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6RA3
| Structural basis for recognition and ring-cleavage of the Pseudomonas quinolone signal (PQS) by AqDC in complex with its product | Descriptor: | 2-(octanoylamino)benzoic acid, Putative dioxygenase (1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase) | Authors: | Wullich, S, Kobus, S, Smits, S.H, Fetzner, S. | Deposit date: | 2019-04-05 | Release date: | 2019-07-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for recognition and ring-cleavage of the Pseudomonas quinolone signal (PQS) by AqdC, a mycobacterial dioxygenase of the alpha / beta-hydrolase fold family. J.Struct.Biol., 207, 2019
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6RA2
| Structural basis for recognition and ring-cleavage of the Pseudomonas quinolone signal (PQS) by AqDC | Descriptor: | Putative dioxygenase (1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase) | Authors: | Wullich, S, Kobus, S, Smits, S.H, Fetzner, S. | Deposit date: | 2019-04-05 | Release date: | 2019-07-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for recognition and ring-cleavage of the Pseudomonas quinolone signal (PQS) by AqdC, a mycobacterial dioxygenase of the alpha / beta-hydrolase fold family. J.Struct.Biol., 207, 2019
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4Q5O
| Crystal structure of EctD from S. alaskensis with 2-oxoglutarate and 5-hydroxyectoine | Descriptor: | (4S,5S)-5-HYDROXY-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, 2-OXOGLUTARIC ACID, Ectoine hydroxylase, ... | Authors: | Hoeppner, A, Widderich, N, Bremer, E, Smits, S.H. | Deposit date: | 2014-04-17 | Release date: | 2014-09-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Crystal structure of the ectoine hydroxylase, a snapshot of the active site. J.Biol.Chem., 289, 2014
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7BBR
| Crystal structure of the sugar acid binding protein DctPAm from Advenella mimigardefordensis strain DPN7T | Descriptor: | 2-KETO-3-DEOXYGLUCONATE, Putative TRAP transporter solute receptor DctP | Authors: | Schaefer, L, Meinert, C, Kobus, S, Hoeppner, A, Smits, S.H, Steinbuechel, A. | Deposit date: | 2020-12-18 | Release date: | 2021-03-24 | Last modified: | 2021-08-25 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Crystal structure of the sugar acid-binding protein CxaP from a TRAP transporter in Advenella mimigardefordensis strain DPN7 T . Febs J., 288, 2021
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