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PDB: 82 件
2XNV
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Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors
分子名称: 2-(2-(4-PHENYLPIPERIDIN-1-YL)ETHYL)-1H-INDOLE, SOLUBLE ACETYLCHOLINE RECEPTOR
著者Rucktooa, P, Akdemir, A, deEsch, I, Sixma, T.K.
登録日2010-08-06
公開日2011-08-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Acetylcholine Binding Protein (Achbp) as Template for Hierarchical in Silico Screening Procedures to Identify Structurally Novel Ligands for the Nicotinic Receptors.
Bioorg.Med.Chem., 19, 2011
2XNT
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Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors
分子名称: (2S)-2-[(4-CHLOROBENZYL)OXY]-2-PHENYLETHANAMINE, BROMIDE ION, SOLUBLE ACETYLCHOLINE RECEPTOR
著者Rucktooa, P, Akdemir, A, deEsch, I, Sixma, T.K.
登録日2010-08-06
公開日2011-08-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Acetylcholine Binding Protein (Achbp) as Template for Hierarchical in Silico Screening Procedures to Identify Structurally Novel Ligands for the Nicotinic Receptors.
Bioorg.Med.Chem., 19, 2011
3ZLJ
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CRYSTAL STRUCTURE OF FULL-LENGTH E.COLI DNA MISMATCH REPAIR PROTEIN MUTS D835R MUTANT IN COMPLEX WITH GT MISMATCHED DNA
分子名称: 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*GP*GP*CP*AP*CP*CP *AP*GP*TP*GP*TP*CP*AP)-3', 5'-D(*TP*GP*AP*CP*AP*CP*TP*GP*GP*TP*GP*CP*TP*TP *GP*GP*CP*AP*GP*CP*TP)-3', DNA MISMATCH REPAIR PROTEIN MUTS
著者Groothuizen, F.S, Fish, A, Petoukhov, M.V, Reumer, A, Manelyte, L, Winterwerp, H.H.K, Marinus, M.G, Lebbink, J.H.G, Svergun, D.I, Friedhoff, P, Sixma, T.K.
登録日2013-02-01
公開日2013-07-17
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Using Stable Muts Dimers and Tetramers to Quantitatively Analyze DNA Mismatch Recognition and Sliding Clamp Formation.
Nucleic Acids Res., 41, 2013
7AI7
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MutS in Intermediate state
分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(P*CP*TP*TP*AP*GP*CP*TP*TP*AP*GP*GP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*CP*CP*TP*AP*AP*CP*TP*AP*AP*G)-3'), ...
著者Fernandez-Leiro, R, Bhairosing-Kok, D, Sixma, T.K, Lamers, M.H.
登録日2020-09-26
公開日2021-03-31
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献The selection process of licensing a DNA mismatch for repair.
Nat.Struct.Mol.Biol., 28, 2021
7AIB
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MutS-MutL in clamp state
分子名称: DNA (30-MER), DNA mismatch repair protein MutL, DNA mismatch repair protein MutS, ...
著者Fernandez-Leiro, R, Bhairosing-Kok, D, Sixma, T.K, Lamers, M.H.
登録日2020-09-26
公開日2021-03-31
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (4.7 Å)
主引用文献The selection process of licensing a DNA mismatch for repair.
Nat.Struct.Mol.Biol., 28, 2021
7AI5
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MutS in Scanning state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*CP*GP*GP*TP*AP*CP*CP*CP*AP*AP*TP*TP*CP*GP*CP*CP*CP*TP*AP*TP*AP*G)-3'), DNA (5'-D(P*CP*TP*AP*TP*AP*GP*GP*GP*CP*GP*AP*AP*TP*TP*GP*GP*GP*TP*AP*CP*CP*G)-3'), ...
著者Fernandez-Leiro, R, Bhairosing-Kok, D, Sixma, T.K, Lamers, M.H.
登録日2020-09-26
公開日2021-03-31
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献The selection process of licensing a DNA mismatch for repair.
Nat.Struct.Mol.Biol., 28, 2021
7AI6
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MutS in mismatch bound state
分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA (25-MER), DNA mismatch repair protein MutS
著者Fernandez-Leiro, R, Bhairosing-Kok, D, Sixma, T.K, Lamers, M.H.
登録日2020-09-26
公開日2021-03-31
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (6.9 Å)
主引用文献The selection process of licensing a DNA mismatch for repair.
Nat.Struct.Mol.Biol., 28, 2021
7AIC
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MutS-MutL in clamp state (kinked clamp domain)
分子名称: DNA (30-MER), DNA mismatch repair protein MutL, DNA mismatch repair protein MutS, ...
著者Fernandez-Leiro, R, Bhairosing-Kok, D, Sixma, T.K, Lamers, M.H.
登録日2020-09-26
公開日2021-03-31
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (5 Å)
主引用文献The selection process of licensing a DNA mismatch for repair.
Nat.Struct.Mol.Biol., 28, 2021
1U9B
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MURINE/HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9
分子名称: UBIQUITIN-CONJUGATING ENZYME E9
著者Tong, H, Hateboer, G, Perrakis, A, Bernards, R, Sixma, T.K.
登録日1997-05-20
公開日1997-07-07
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system.
J.Biol.Chem., 272, 1997
5AKD
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BU of 5akd by Molmil
MutS in complex with the N-terminal domain of MutL - crystal form 3
分子名称: DNA MISMATCH REPAIR PROTEIN MUTL, DNA MISMATCH REPAIR PROTEIN MUTS, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Groothuizen, F.S, Winkler, I, Cristovao, M, Fish, A, Winterwerp, H.H.K, Reumer, A, Marx, A.D, Hermans, N, Nicholls, R.A, Murshudov, G.N, Lebbink, J.H.G, Friedhoff, P, Sixma, T.K.
登録日2015-03-03
公開日2015-07-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (7.6 Å)
主引用文献MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.
Elife, 4, 2015
5AKB
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MutS in complex with the N-terminal domain of MutL - crystal form 1
分子名称: DNA MISMATCH REPAIR PROTEIN MUTL, DNA MISMATCH REPAIR PROTEIN MUTS, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Groothuizen, F.S, Winkler, I, Cristovao, M, Fish, A, Winterwerp, H.H.K, Reumer, A, Marx, A.D, Hermans, N, Nicholls, R.A, Murshudov, G.N, Lebbink, J.H.G, Friedhoff, P, Sixma, T.K.
登録日2015-03-03
公開日2015-07-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (4.71 Å)
主引用文献MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.
Elife, 4, 2015
5AKC
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MutS in complex with the N-terminal domain of MutL - crystal form 2
分子名称: DNA MISMATCH REPAIR PROTEIN MUTL, DNA MISMATCH REPAIR PROTEIN MUTS, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Groothuizen, F.S, Winkler, I, Cristovao, M, Fish, A, Winterwerp, H.H.K, Reumer, A, Marx, A.D, Hermans, N, Nicholls, R.A, Murshudov, G.N, Lebbink, J.H.G, Friedhoff, P, Sixma, T.K.
登録日2015-03-03
公開日2015-07-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (6.6 Å)
主引用文献MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.
Elife, 4, 2015
1U9A
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BU of 1u9a by Molmil
HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9
分子名称: UBIQUITIN-CONJUGATING ENZYME
著者Tong, H, Hateboer, G, Perrakis, A, Bernards, R, Sixma, T.K.
登録日1997-02-11
公開日1997-05-15
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system.
J.Biol.Chem., 272, 1997
1TC3
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BU of 1tc3 by Molmil
TRANSPOSASE TC3A1-65 FROM CAENORHABDITIS ELEGANS
分子名称: DNA (5'-D(*AP*GP*GP*GP*GP*GP*GP*GP*TP*CP*CP*TP*AP*TP*AP*GP*A P*AP*CP*TP*T)-3'), DNA (5'-D(*AP*GP*TP*TP*CP*TP*AP*TP*AP*GP*GP*AP*CP*CP*CP*CP*C P*CP*CP*T)-3'), PROTEIN (TC3 TRANSPOSASE)
著者Van Pouderoyen, G, Ketting, R.F, Perrakis, A, Plasterk, R.H.A, Sixma, T.K.
登録日1997-07-07
公開日1997-11-21
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA.
EMBO J., 16, 1997
2UZ6
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BU of 2uz6 by Molmil
AChBP-targeted a-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-CONOTOXIN TXIA(A10L), GLYCEROL, ...
著者Ulens, C, Dutertre, S, Buttner, R, Fish, A, van Elk, R, Kendel, Y, Hopping, G, Alewood, P.F, Schroeder, C, Nicke, A, Smit, A.B, Sixma, T.K, Lewis, R.J.
登録日2007-04-25
公開日2007-08-07
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Achbp-Targeted Alpha-Conotoxin Correlates Distinct Binding Orientations with Nachr Subtype Selectivity
Embo J., 26, 2007
2WTU
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BU of 2wtu by Molmil
Crystal structure of Escherichia coli MutS in complex with a 16 basepair oligo containing an A.A mismatch.
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, DNA, ...
著者Natrajan, G, Lebbink, J.H, Reumer, A, Fish, A, Winterwerp, H.H, Sixma, T.K.
登録日2009-09-22
公開日2010-02-09
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Magnesium coordination controls the molecular switch function of DNA mismatch repair protein MutS.
J. Biol. Chem., 285, 2010
1LTB
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BU of 1ltb by Molmil
2.6 ANGSTROMS CRYSTAL STRUCTURE OF PARTIALLY-ACTIVATED E. COLI HEAT-LABILE ENTEROTOXIN (LT)
分子名称: HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B
著者Merritt, E.A, Sixma, T.K, Hol, W.G.J.
登録日1993-09-15
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of partially-activated E. coli heat-labile enterotoxin (LT) at 2.6 A resolution.
FEBS Lett., 337, 1994
2YBF
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Complex of Rad18 (Rad6 binding domain) with Rad6b
分子名称: BETA-MERCAPTOETHANOL, E3 UBIQUITIN-PROTEIN LIGASE RAD18, SODIUM ION, ...
著者Hibbert, R.G, Sixma, T.K.
登録日2011-03-08
公開日2011-04-20
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献E3 Ligase Rad18 Promotes Monoubiquitination Rather Than Ubiquitin Chain Formation by E2 Enzyme Rad6.
Proc.Natl.Acad.Sci.USA, 108, 2011
2C9T
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Crystal Structure Of Acetylcholine Binding Protein (AChBP) From Aplysia Californica In Complex With alpha-Conotoxin ImI
分子名称: ALPHA-CONOTOXIN IMI, SOLUBLE ACETYLCHOLINE RECEPTOR
著者Ulens, C, Hogg, R.C, Celie, P.H, Bertrand, D, Tsetlin, V, Smit, A.B, Sixma, T.K.
登録日2005-12-14
公開日2006-02-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural Determinants of Selective {Alpha}-Conotoxin Binding to a Nicotinic Acetylcholine Receptor Homolog Achbp.
Proc.Natl.Acad.Sci.USA, 103, 2006
2YB6
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Native human Rad6
分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, UBIQUITIN-CONJUGATING ENZYME E2 B
著者Hibbert, R.G, Sixma, T.K.
登録日2011-03-02
公開日2011-04-20
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献E3 Ligase Rad18 Promotes Monoubiquitination Rather Than Ubiquitin Chain Formation by E2 Enzyme Rad6.
Proc.Natl.Acad.Sci.USA, 108, 2011
2Y7Y
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APLYSIA CALIFORNICA ACHBP IN APO STATE
分子名称: SOLUBLE ACETYLCHOLINE RECEPTOR
著者Ulens, C, Akdemir, A, Jongejan, A, van Elk, R, Bertrand, S, Perrakis, A, Leurs, R, Smit, A.B, Sixma, T.K, Bertrand, D, De Esch, I.J.
登録日2011-02-02
公開日2011-03-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.895 Å)
主引用文献Use of Acetylcholine Binding Protein in the Search for Novel Alpha7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X-Ray Analysis.
J.Med.Chem., 52, 2009
2W8F
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Aplysia californica AChBP bound to in silico compound 31
分子名称: (3-EXO)-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8,8-DIMETHYL-8-AZONIABICYCLO[3.2.1]OCTANE, SOLUBLE ACETYLCHOLINE RECEPTOR
著者Ulens, C, Akdemir, A, Jongejan, A, van Elk, R, Edink, E, Bertrand, S, Perrakis, A, Leurs, R, Smit, A.B, Sixma, T.K, Bertrand, D, de Esch, I.J.
登録日2009-01-16
公開日2009-04-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Use of Acetylcholine Binding Protein in the Search for Novel Alpha7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X- Ray Analysis.
J.Med.Chem., 52, 2009
2BR8
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BU of 2br8 by Molmil
Crystal Structure of Acetylcholine-binding Protein (AChBP) from Aplysia californica in complex with an alpha-conotoxin PnIA variant
分子名称: ALPHA-CONOTOXIN PNIA, SOLUBLE ACETYLCHOLINE RECEPTOR, SULFATE ION
著者Celie, P.H.N, Kasheverov, I.E, Mordvintsev, D.Y, Hogg, R.C, van Nierop, P, van Elk, R, van Rossum-Fikkert, S.E, Zhmak, M.N, Bertrand, D, Tsetlin, V, Sixma, T.K, Smit, A.B.
登録日2005-05-03
公開日2005-06-07
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of Nicotinic Acetylcholine Receptor Homolog Achbp in Complex with an Alpha-Conotoxin Pnia Variant
Nat.Struct.Mol.Biol., 12, 2005
2UYZ
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Non-covalent complex between Ubc9 and SUMO1
分子名称: SMALL UBIQUITIN-RELATED MODIFIER 1, SODIUM ION, SUMO-CONJUGATING ENZYME UBC9
著者Knipscheer, P, van Dijk, W.J, Olsen, J.V, Mann, M, Sixma, T.K.
登録日2007-04-21
公開日2007-06-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation.
EMBO J., 26, 2007
2VRR
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Structure of SUMO modified Ubc9
分子名称: FORMIC ACID, SMALL UBIQUITIN-RELATED MODIFIER 1, SODIUM ION, ...
著者Knipscheer, P, Flotho, A, Klug, H, Olsen, J.V, van Dijk, W.J, Fish, A, Johnson, E.S, Mann, M, Sixma, T.K, Pichler, A.
登録日2008-04-13
公開日2008-08-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Ubc9 sumoylation regulates SUMO target discrimination.
Mol. Cell, 31, 2008

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