1A0A
| PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4/DNA COMPLEX | 分子名称: | DNA (5'-D(*CP*TP*AP*GP*TP*CP*CP*CP*AP*CP*GP*TP*GP*TP*GP*AP*G )-3'), DNA (5'-D(*CP*TP*CP*AP*CP*AP*CP*GP*TP*GP*GP*GP*AP*CP*TP*AP*G )-3'), PROTEIN (PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4) | 著者 | Shimizu, T, Toumoto, A, Ihara, K, Shimizu, M, Kyogoku, Y, Ogawa, N, Oshima, Y, Hakoshima, T. | 登録日 | 1997-11-27 | 公開日 | 1998-03-18 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition. EMBO J., 16, 1997
|
|
7YTX
| Crystal structure of TLR8 in complex with its antagonist | 分子名称: | (2R,6R)-4-(8-cyanoquinolin-5-yl)-N-[(3S,4R)-4-fluoranylpyrrolidin-3-yl]-6-methyl-morpholine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Shimizu, T, Sakaniwa, K. | 登録日 | 2022-08-16 | 公開日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A novel Toll-like receptor 7/8-specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus. Eur.J.Pharmacol., 957, 2023
|
|
1KCD
| Endopolygalacturonase I from Stereum purpureum complexed with two galacturonate at 1.15 A resolution. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ENDOPOLYGALACTURONASE, ... | 著者 | Shimizu, T, Nakatsu, T, Miyairi, K, Okuno, T, Kato, H. | 登録日 | 2001-11-08 | 公開日 | 2002-06-05 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Active-site architecture of endopolygalacturonase I from Stereum purpureum revealed by crystal structures in native and ligand-bound forms at atomic resolution. Biochemistry, 41, 2002
|
|
1KCC
| Endopolygalacturonase I from Stereum purpureum complexed with a galacturonate at 1.00 A resolution. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ENDOPOLYGALACTURONASE, ... | 著者 | Shimizu, T, Nakatsu, T, Miyairi, K, Okuno, T, Kato, H. | 登録日 | 2001-11-08 | 公開日 | 2002-06-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Active-site architecture of endopolygalacturonase I from Stereum purpureum revealed by crystal structures in native and ligand-bound forms at atomic resolution. Biochemistry, 41, 2002
|
|
5HN4
| Crystal structure of beta-decarboxylating dehydrogenase (TK0280) from Thermococcus kodakarensis complexed with Mn and homoisocitrate | 分子名称: | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylic acid, Homoisocitrate dehydrogenase, IMIDAZOLE, ... | 著者 | Shimizu, T, Tomita, T, Nishiyama, M. | 登録日 | 2016-01-18 | 公開日 | 2016-12-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Structure and function of an ancestral-type beta-decarboxylating dehydrogenase from Thermococcus kodakarensis Biochem. J., 474, 2017
|
|
5HN6
| Crystal structure of beta-decarboxylating dehydrogenase (TK0280) from Thermococcus kodakarensis complexed with Mn and 3-isopropylmalate | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-ISOPROPYLMALIC ACID, Homoisocitrate dehydrogenase, ... | 著者 | Shimizu, T, Tomita, T, Nishiyama, M. | 登録日 | 2016-01-18 | 公開日 | 2016-12-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure and function of an ancestral-type beta-decarboxylating dehydrogenase from Thermococcus kodakarensis Biochem. J., 474, 2017
|
|
5HN5
| Crystal structure of beta-decarboxylating dehydrogenase (TK0280) from Thermococcus kodakarensis complexed with Mn and isocitrate | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Homoisocitrate dehydrogenase, ISOCITRIC ACID, ... | 著者 | Shimizu, T, Tomita, T, Nishiyama, M. | 登録日 | 2016-01-18 | 公開日 | 2016-12-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure and function of an ancestral-type beta-decarboxylating dehydrogenase from Thermococcus kodakarensis Biochem. J., 474, 2017
|
|
5HN3
| |
1K5C
| Endopolygalacturonase I from Stereum purpureum at 0.96 A resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ENDOPOLYGALACTURONASE, ... | 著者 | Shimizu, T, Nakatsu, T, Miyairi, K, Okuno, T, Kato, H. | 登録日 | 2001-10-10 | 公開日 | 2002-06-05 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (0.96 Å) | 主引用文献 | Active-site architecture of endopolygalacturonase I from Stereum purpureum revealed by crystal structures in native and ligand-bound forms at atomic resolution. Biochemistry, 41, 2002
|
|
5EIO
| Crystal structure of LysY from Thermus thermophilus complexed with NADP+ and LysW-gamma-aminoadipic semialdehyde | 分子名称: | ACETIC ACID, N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Shimizu, T, Tomita, T, Nishiyama, M. | 登録日 | 2015-10-30 | 公開日 | 2016-03-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal Structure of the LysYLysW Complex from Thermus thermophilus. J.Biol.Chem., 291, 2016
|
|
5EIN
| Crystal structure of C148A mutant of LysY from Thermus thermophilus in complex with NADP+ and LysW-gamma-aminoadipic acid | 分子名称: | Alpha-aminoadipate carrier protein LysW, FORMIC ACID, N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase, ... | 著者 | Shimizu, T, Tomita, T, Nishiyama, M. | 登録日 | 2015-10-30 | 公開日 | 2016-03-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal Structure of the LysYLysW Complex from Thermus thermophilus. J.Biol.Chem., 291, 2016
|
|
5GIC
| Crystal structure of VDR in complex with DLAM-2P | 分子名称: | (3~{R},5~{S})-5-[(2~{R})-2-[(1~{R},3~{a}~{S},4~{Z},7~{a}~{R})-7~{a}-methyl-4-[(2~{E})-2-[(3~{S},5~{R})-2-methylidene-3,5-bis(oxidanyl)cyclohexylidene]ethylidene]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-1-yl]propyl]-3-methyl-3-oxidanyl-1-(2-phenylethyl)pyrrolidin-2-one, SRC1, Vitamin D3 receptor | 著者 | Shimizu, T, Asano, L. | 登録日 | 2016-06-23 | 公開日 | 2016-12-07 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.352 Å) | 主引用文献 | Regulation of the vitamin D receptor by vitamin D lactam derivatives. Febs Lett., 590, 2016
|
|
1DPF
| CRYSTAL STRUCTURE OF A MG-FREE FORM OF RHOA COMPLEXED WITH GDP | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, RHOA | 著者 | Shimizu, T, Ihara, K, Maesaki, R, Kuroda, S, Kaibuchi, K, Hakoshima, T. | 登録日 | 1999-12-27 | 公開日 | 2000-06-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism. J.Biol.Chem., 275, 2000
|
|
1ISN
| Crystal structure of merlin FERM domain | 分子名称: | merlin | 著者 | Shimizu, T, Seto, A, Maita, N, Hamada, K, Tsukita, S, Tsukita, S, Hakoshima, T. | 登録日 | 2001-12-13 | 公開日 | 2002-04-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain. J.Biol.Chem., 277, 2002
|
|
1UIX
| Coiled-coil structure of the RhoA-binding domain in Rho-kinase | 分子名称: | Rho-associated kinase | 著者 | Shimizu, T, Ihara, K, Maesaki, R, Amano, M, Kaibuchi, K, Hakoshima, T. | 登録日 | 2003-07-23 | 公開日 | 2003-10-21 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase J.Biol.Chem., 278, 2003
|
|
1VMO
| CRYSTAL STRUCTURE OF VITELLINE MEMBRANE OUTER LAYER PROTEIN I (VMO-I): A FOLDING MOTIF WITH HOMOLOGOUS GREEK KEY STRUCTURES RELATED BY AN INTERNAL THREE-FOLD SYMMETRY | 分子名称: | VITELLINE MEMBRANE OUTER LAYER PROTEIN I | 著者 | Shimizu, T, Vassylyev, D.G, Kido, S, Doi, Y, Morikawa, K. | 登録日 | 1994-01-06 | 公開日 | 1994-05-31 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of vitelline membrane outer layer protein I (VMO-I): a folding motif with homologous Greek key structures related by an internal three-fold symmetry. EMBO J., 13, 1994
|
|
3W0I
| Crystal Structure of Rat VDR Ligand Binding Domain in Complex with Novel Nonsecosteroidal Ligands | 分子名称: | (2S)-3-{4-[3-(4-{[(2R)-2-hydroxy-3,3-dimethylbutyl]oxy}phenyl)pentan-3-yl]phenoxy}propane-1,2-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 Receptor | 著者 | Shimizu, T, Asano, L, Kuwabara, N, Ito, I, Waku, T, Yanagisawa, J, Miyachi, H. | 登録日 | 2012-10-30 | 公開日 | 2013-10-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands. Febs Lett., 587, 2013
|
|
3W0H
| Crystal Structure of Rat VDR Ligand Binding Domain in Complex with Novel Nonsecosteroidal Ligands | 分子名称: | (2S)-3-{4-[4-(4-{[(2R)-2-hydroxy-3,3-dimethylbutyl]oxy}phenyl)heptan-4-yl]phenoxy}propane-1,2-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | 著者 | Shimizu, T, Asano, L, Kuwabara, N, Ito, I, Waku, T, Yanagisawa, J, Miyachi, H. | 登録日 | 2012-10-30 | 公開日 | 2013-10-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands. Febs Lett., 587, 2013
|
|
3W0G
| Crystal Structure of Rat VDR Ligand Binding Domain in Complex with Novel Nonsecosteroidal Ligands | 分子名称: | (2S)-3-{4-[2-(4-{[(2R)-2-hydroxy-3,3-dimethylbutyl]oxy}phenyl)propan-2-yl]phenoxy}propane-1,2-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | 著者 | Shimizu, T, Asano, L, Kuwabara, N, Ito, I, Waku, T, Yanagisawa, J, Miyachi, H. | 登録日 | 2012-10-30 | 公開日 | 2013-10-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands. Febs Lett., 587, 2013
|
|
3W0J
| Crystal Structure of Rat VDR Ligand Binding Domain in Complex with Novel Nonsecosteroidal Ligands | 分子名称: | (2S)-3-{4-[2-(4-{[(2R)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)propan-2-yl]-2-methylphenoxy}propane-1,2-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 Receptor | 著者 | Shimizu, T, Asano, L, Kuwabara, N, Ito, I, Waku, T, Yanagisawa, J, Miyachi, H. | 登録日 | 2012-10-30 | 公開日 | 2013-10-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands. Febs Lett., 587, 2013
|
|
5H6K
| DNA targeting ADP-ribosyltransferase Pierisin-1 | 分子名称: | 1,2-ETHANEDIOL, Pierisin-1 | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | 登録日 | 2016-11-14 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1 J. Biol. Chem., 292, 2017
|
|
5H6N
| DNA targeting ADP-ribosyltransferase Pierisin-1, autoinhibitory form | 分子名称: | Pierisin-1 | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | 登録日 | 2016-11-14 | 公開日 | 2017-08-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1 J. Biol. Chem., 292, 2017
|
|
5H6L
| DNA targeting ADP-ribosyltransferase Pierisin-1 in complex with beta-NAD+ | 分子名称: | 1,2-ETHANEDIOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pierisin-1 | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | 登録日 | 2016-11-14 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1 J. Biol. Chem., 292, 2017
|
|
5H6M
| DNA targeting ADP-ribosyltransferase Pierisin-1 | 分子名称: | 1,2-ETHANEDIOL, Pierisin-1 | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | 登録日 | 2016-11-14 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1 J. Biol. Chem., 292, 2017
|
|
7C77
| Cryo-EM structure of mouse TLR3 in complex with UNC93B1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ... | 著者 | Ohto, U, Ishida, H, Shimizu, T. | 登録日 | 2020-05-23 | 公開日 | 2021-01-06 | 最終更新日 | 2021-02-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structures of Toll-like receptors in complex with UNC93B1. Nat.Struct.Mol.Biol., 28, 2021
|
|