8K8E
 
 | | Human gamma-secretase in complex with a substrate mimetic | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Shi, Y.G, Zhou, R, Wolfe, M.S. | | 登録日 | 2023-07-29 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Familial Alzheimer mutations stabilize synaptotoxic gamma-secretase-substrate complexes.
Cell Rep, 43, 2024
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4GG4
 | | Crystal structure of the TAL effector dHax3 bound to specific DNA-RNA hybrid | | 分子名称: | DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*AP*TP*CP*TP*CP*TP*CP*T)-3'), Hax3, RNA (5'-R(*AP*GP*AP*GP*AP*GP*AP*UP*AP*AP*AP*GP*GP*GP*AP*CP*A)-3') | | 著者 | Yin, P, Deng, D, Yan, C.Y, Pan, X.J, Yan, N, Shi, Y.G. | | 登録日 | 2012-08-05 | | 公開日 | 2012-10-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | | 主引用文献 | Specific DNA-RNA hybrid recognition by TAL effectors
Cell Rep, 2, 2012
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7D7F
 | | Structure of PKD1L3-CTD/PKD2L1 in calcium-bound state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Polycystic kidney disease 2-like 1 protein, ... | | 著者 | Su, Q, Shi, Y.G. | | 登録日 | 2020-10-03 | | 公開日 | 2021-09-01 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for Ca 2+ activation of the heteromeric PKD1L3/PKD2L1 channel.
Nat Commun, 12, 2021
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2Y1Q
 | | Crystal Structure of ClpC N-terminal Domain | | 分子名称: | NEGATIVE REGULATOR OF GENETIC COMPETENCE CLPC/MECB, SULFATE ION | | 著者 | Wang, F, Mei, Z.Q, Wang, J.W, Shi, Y.G. | | 登録日 | 2010-12-10 | | 公開日 | 2011-03-16 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure and Mechanism of the Hexameric Meca-Clpc Molecular Machine.
Nature, 471, 2011
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2Y1R
 | | Structure of MecA121 & ClpC N-domain complex | | 分子名称: | ADAPTER PROTEIN MECA 1, NEGATIVE REGULATOR OF GENETIC COMPETENCE CLPC/MECB, S,R MESO-TARTARIC ACID | | 著者 | Wang, F, Mei, Z.Q, Wang, J.W, Shi, Y.G. | | 登録日 | 2010-12-10 | | 公開日 | 2011-03-16 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.595 Å) | | 主引用文献 | Structure and Mechanism of the Hexameric Meca-Clpc Molecular Machine.
Nature, 471, 2011
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4GJP
 | | Crystal structure of the TAL effector dHax3 bound to dsDNA containing repetitive methyl-CpG | | 分子名称: | DNA (5'-D(*AP*GP*AP*GP*AP*CP*GP*CP*GP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*(5CM)P*GP*(5CM)P*GP*TP*CP*TP*CP*T)-3'), Hax3, ... | | 著者 | Yan, N, Deng, D, Yan, C.Y, Yin, P, Pan, X.J, Shi, Y.G. | | 登録日 | 2012-08-10 | | 公開日 | 2012-10-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Crystal structure of a protein complex
To be Published
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4GJR
 | | Crystal structure of the TAL effector dHax3 bound to methylated dsDNA | | 分子名称: | DNA (5'-D(*AP*GP*GP*GP*AP*GP*GP*TP*AP*GP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*(5CM)P*TP*AP*(5CM)P*CP*TP*CP*(5CM)P*CP*T)-3'), Hax3 | | 著者 | Yan, N, Deng, D, Yan, C.Y, Yin, P, Pan, X.J, Shi, Y.G. | | 登録日 | 2012-08-10 | | 公開日 | 2012-10-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystal structure of a protein complex
To be Published
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3PXG
 | | Structure of MecA121 and ClpC1-485 complex | | 分子名称: | Adapter protein mecA 1, Negative regulator of genetic competence ClpC/MecB | | 著者 | Wang, F, Mei, Z.Q, Wang, J.W, Shi, Y.G. | | 登録日 | 2010-12-09 | | 公開日 | 2011-03-16 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.654 Å) | | 主引用文献 | Structure and mechanism of the hexameric MecA-ClpC molecular machine.
Nature, 471, 2011
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4DDP
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4F6O
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3PXI
 | | Structure of MecA108:ClpC | | 分子名称: | Adapter protein mecA 1, Negative regulator of genetic competence ClpC/MecB | | 著者 | Wang, F, Mei, Z.Q, Wang, J.W, Shi, Y.G. | | 登録日 | 2010-12-09 | | 公開日 | 2011-03-16 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (6.926 Å) | | 主引用文献 | Structure and mechanism of the hexameric MecA-ClpC molecular machine.
Nature, 471, 2011
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4HZU
 | | Structure of a bacterial energy-coupling factor transporter | | 分子名称: | Energy-coupling factor transporter ATP-binding protein EcfA 1, Energy-coupling factor transporter ATP-binding protein EcfA 2, Energy-coupling factor transporter transmembrane protein EcfT, ... | | 著者 | Wang, T.L, Fu, G.B, Pan, X.J, Shi, Y.G. | | 登録日 | 2012-11-15 | | 公開日 | 2013-04-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.53 Å) | | 主引用文献 | Structure of a bacterial energy-coupling factor transporter.
Nature, 497, 2013
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5GJR
 | | An atomic structure of the human 26S proteasome | | 分子名称: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | | 著者 | Huang, X.L, Luan, B, Wu, J.P, Shi, Y.G. | | 登録日 | 2016-07-01 | | 公開日 | 2016-09-07 | | 最終更新日 | 2019-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | An atomic structure of the human 26S proteasome.
Nat. Struct. Mol. Biol., 23, 2016
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5FN4
 | | Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble | | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | | 登録日 | 2015-11-10 | | 公開日 | 2015-12-16 | | 最終更新日 | 2019-09-11 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
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5FN5
 | | Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble | | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | | 登録日 | 2015-11-10 | | 公開日 | 2015-12-16 | | 最終更新日 | 2019-09-11 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
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4F6P
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4DJI
 | | Structure of glutamate-GABA antiporter GadC | | 分子名称: | Probable glutamate/gamma-aminobutyrate antiporter | | 著者 | Ma, D, Lu, P.L, Yan, C.Y, Fan, C, Yin, P, Wang, J.W, Shi, Y.G. | | 登録日 | 2012-02-02 | | 公開日 | 2012-03-14 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.187 Å) | | 主引用文献 | Structure and mechanism of a glutamate-GABA antiporter
Nature, 483, 2012
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4DJK
 | | Structure of glutamate-GABA antiporter GadC | | 分子名称: | Probable glutamate/gamma-aminobutyrate antiporter | | 著者 | Ma, D, Lu, P.L, Yan, C.Y, Fan, C, Yin, P, Wang, J.W, Shi, Y.G. | | 登録日 | 2012-02-02 | | 公開日 | 2012-03-14 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.097 Å) | | 主引用文献 | Structure and mechanism of a glutamate-GABA antiporter
Nature, 483, 2012
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5FN2
 | | Cryo-EM structure of gamma secretase in complex with a drug DAPT | | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | | 登録日 | 2015-11-10 | | 公開日 | 2015-12-16 | | 最終更新日 | 2019-09-04 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
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5GJQ
 | | Structure of the human 26S proteasome bound to USP14-UbAl | | 分子名称: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | | 著者 | Huang, X.L, Luan, B, Wu, J.P, Shi, Y.G. | | 登録日 | 2016-07-01 | | 公開日 | 2016-08-17 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | An atomic structure of the human 26S proteasome.
Nat. Struct. Mol. Biol., 23, 2016
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5FN3
 | | Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | | 登録日 | 2015-11-10 | | 公開日 | 2015-12-16 | | 最終更新日 | 2019-09-11 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
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3JCO
 | | Structure of yeast 26S proteasome in M1 state derived from Titan dataset | | 分子名称: | 26S protease regulatory subunit 4 homolog, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B homolog, ... | | 著者 | Luan, B, Huang, X.L, Wu, J.P, Shi, Y.G, Wang, F. | | 登録日 | 2016-01-06 | | 公開日 | 2016-06-15 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Structure of an endogenous yeast 26S proteasome reveals two major conformational states.
Proc.Natl.Acad.Sci.USA, 113, 2016
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4M9X
 | | Crystal structure of CED-4 bound CED-3 fragment | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ... | | 著者 | Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G. | | 登録日 | 2013-08-15 | | 公開日 | 2013-10-23 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.344 Å) | | 主引用文献 | Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
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4M9Y
 | | Crystal structure of CED-4 bound CED-3 fragment | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ... | | 著者 | Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G. | | 登録日 | 2013-08-15 | | 公開日 | 2013-10-23 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | | 主引用文献 | Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
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4M9S
 | | crystal structure of CED-4 bound CED-3 fragment | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ... | | 著者 | Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G. | | 登録日 | 2013-08-15 | | 公開日 | 2013-10-23 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3.207 Å) | | 主引用文献 | Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
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