3KYR
 
 | | Bace-1 in complex with a norstatine type inhibitor | | 分子名称: | 3-[[(2S)-2-[[[(2S)-2-[[(2S)-2-[[(2S)-2-azanyl-3-(1H-1,2,3,4-tetrazol-5-ylcarbonylamino)propanoyl]amino]-3-methyl-butanoyl]amino]-4-methyl-pentanoyl]amino]methyl]-2-hydroxy-4-phenyl-butanoyl]amino]benzoic acid, Beta-secretase 1 | | 著者 | Lindberg, J.D, Borkakoti, N, Derbyshire, D, Nystrom, S. | | 登録日 | 2009-12-07 | | 公開日 | 2010-12-29 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Investigation of a-phenylnorstatine and a-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibiotrs
To be Published
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5ZU2
 | | Effect of mutation (R554A) on FAD modification in Aspergillus oryzae RIB40formate oxidase | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Mikami, B, Uchida, H, Doubayashi, D. | | 登録日 | 2018-05-06 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.441 Å) | | 主引用文献 | The microenvironment surrounding FAD mediates its conversion to 8-formyl-FAD in Aspergillus oryzae RIB40 formate oxidase.
J.Biochem., 166, 2019
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5ZU3
 | | Effect of mutation (R554K) on FAD modification in Aspergillus oryzae RIB40formate oxidase | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, Formate oxidase, ... | | 著者 | Mikami, B, Uchida, H, Doubayashi, D. | | 登録日 | 2018-05-06 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The microenvironment surrounding FAD mediates its conversion to 8-formyl-FAD in Aspergillus oryzae RIB40 formate oxidase.
J.Biochem., 166, 2019
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2KN1
 | | Solution NMR Structure of BCMA | | 分子名称: | Tumor necrosis factor receptor superfamily member 17 | | 著者 | Pellegrini, M, Willen, L, Perroud, M, Krushinskie, D, Strauch, K, Cuervo, H, Sun, Y, Day, E.S, Schneider, P, Zheng, T.S. | | 登録日 | 2009-08-11 | | 公開日 | 2011-02-23 | | 最終更新日 | 2013-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions.
Febs J., 280, 2013
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2KN0
 | | Solution NMR Structure of xenopus Fn14 | | 分子名称: | Fn14 | | 著者 | Pellegrini, M, Willen, L, Perroud, M, Krushinskie, D, Strauch, K, Cuervo, H, Sun, Y, Day, E.S, Schneider, P, Zheng, T.S. | | 登録日 | 2009-08-11 | | 公開日 | 2011-06-29 | | 最終更新日 | 2013-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions.
Febs J., 280, 2013
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2KMZ
 | | NMR Structure of hFn14 | | 分子名称: | Tumor necrosis factor receptor superfamily member 12A | | 著者 | Pellegrini, M, Willen, L, Perroud, M, Krushinskie, D, Strauch, K, Cuervo, H, Sun, Y, Day, E.S, Schneider, P, Zheng, T.S. | | 登録日 | 2009-08-10 | | 公開日 | 2011-06-29 | | 最終更新日 | 2013-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions.
Febs J., 280, 2013
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4DPF
 | | BACE-1 in complex with a HEA-macrocyclic type inhibitor | | 分子名称: | Beta-secretase 1, N-[(4S,8E,11S)-4-[(1R)-1-hydroxy-2-{[3-(propan-2-yl)benzyl]amino}ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(18),8,14,16-tetraen-16-yl]-N-methylmethanesulfonamide | | 著者 | Lindberg, J, Borkakoti, N, Derbyshire, D. | | 登録日 | 2012-02-13 | | 公開日 | 2012-07-11 | | 最終更新日 | 2013-01-02 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: design, synthesis and X-ray crystal structures of enzyme inhibitor complexes.
Bioorg.Med.Chem., 20, 2012
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4GMI
 | | BACE-1 in complex with HEA-type macrocyclic inhibitor, MV078571 | | 分子名称: | (4S,8E)-4-[(1R)-2-{[2-(5-tert-butyl-1,3-oxazol-2-yl)propan-2-yl]amino}-1-hydroxyethyl]-16-methyl-6-oxa-3-azabicyclo[12.3.1]octadeca-1(18),8,14,16-tetraene-2,13-dione, ACETATE ION, Beta-secretase 1, ... | | 著者 | Lindberg, J.D, Derbyshire, D. | | 登録日 | 2012-08-16 | | 公開日 | 2013-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Design and synthesis of novel BACE-1 inhibitors
To be Published
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3AK4
 | | Crystal structure of NADH-dependent quinuclidinone reductase from agrobacterium tumefaciens | | 分子名称: | NADH-dependent quinuclidinone reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Miyakawa, T, Kataoka, M, Takeshita, D, Nomoto, F, Nagata, K, Shimizu, S, Tanokura, M. | | 登録日 | 2010-07-07 | | 公開日 | 2011-07-13 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of NADH-dependent quinuclidinone reductase from Agrobacterium tumefaciens
To be Published
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3UUO
 | | The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as PDE10 inhibitors for the treatment of Schizophrenia | | 分子名称: | 6-methoxy-3,8-dimethyl-4-(piperazin-1-yl)-1H-pyrazolo[3,4-b]quinoline, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Ho, G.D, Yang, S, Smotryski, J, Bercovici, A, Nechuta, T, Smith, E.M, McElroy, W, Tan, Z, Tulshian, D, Mckittrick, B, Greenlee, W.J, Hruza, A, Xiao, L, Rindgen, D, Guzzi, M, Zhang, X, Bleickardt, C, Mullins, D, Hodgson, R. | | 登録日 | 2011-11-28 | | 公開日 | 2012-01-25 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.
Bioorg.Med.Chem.Lett., 22, 2012
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3UI7
 | | Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia | | 分子名称: | 6-methoxy-3,8-dimethyl-4-(morpholin-4-ylmethyl)-1H-pyrazolo[3,4-b]quinoline, MAGNESIUM ION, ZINC ION, ... | | 著者 | Yang, S, Smotryski, J, Mcelroy, W, Ho, G, Tulshian, D, Greenlee, W.J, Hodgson, R, Xiao, L, Hruza, A. | | 登録日 | 2011-11-04 | | 公開日 | 2011-12-21 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.
Bioorg.Med.Chem.Lett., 22, 2012
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3WFS
 | | tRNA processing enzyme complex 3 | | 分子名称: | Poly A polymerase, RNA (74-MER), SULFATE ION | | 著者 | Yamashita, S, Takeshita, D, Tomita, K. | | 登録日 | 2013-07-23 | | 公開日 | 2014-01-01 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.311 Å) | | 主引用文献 | Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase
Structure, 22, 2014
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3WFR
 | | tRNA processing enzyme complex 2 | | 分子名称: | CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | | 著者 | Yamashita, S, Takeshita, D, Tomita, K. | | 登録日 | 2013-07-23 | | 公開日 | 2014-01-01 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.501 Å) | | 主引用文献 | Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase
Structure, 22, 2014
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3WFO
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3WFP
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3WFQ
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1WRI
 | | Crystal Structure of Ferredoxin isoform II from E. arvense | | 分子名称: | BENZAMIDINE, FE2/S2 (INORGANIC) CLUSTER, Ferredoxin II | | 著者 | Kurisu, G, Nishiyama, D, Kusunoki, M, Fujikawa, S, Katoh, M, Hanke, G.T, Hase, T, Teshima, K. | | 登録日 | 2004-10-18 | | 公開日 | 2004-11-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | A structural basis of Equisetum arvense ferredoxin isoform II producing an alternative electron transfer with ferredoxin-NADP+ reductase.
J.Biol.Chem., 280, 2005
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2HJW
 | | Crystal Structure of the BC domain of ACC2 | | 分子名称: | Acetyl-CoA carboxylase 2 | | 著者 | Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S. | | 登録日 | 2006-07-02 | | 公開日 | 2007-07-03 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2.
Proteins, 70, 2008
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