5JQN
 
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6YPA
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3HKX
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4LF0
 | | The E142D mutant of the amidase from Geobacillus pallidus | | 分子名称: | Aliphatic amidase | | 著者 | Sewell, B.T, Weber, B.W, Kimani, S.W, Cowan, D.A, Hunter, R, Venter, G.A, Gumbart, J.C, Thuku, R.N, Varsani, A. | | 登録日 | 2013-06-26 | | 公開日 | 2013-08-21 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning.
J.Biol.Chem., 288, 2013
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7Z0V
 | | A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability | | 分子名称: | CHLORIDE ION, COBALT (II) ION, Nitrile hydratase, ... | | 著者 | Van Wyk, J.C, Cowan, D.A, Danson, M.J, Tsekoa, T.L, Sayed, M.F, Sewell, B.T. | | 登録日 | 2022-02-23 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Engineering enhanced thermostability into the Geobacillus pallidus nitrile hydratase.
Curr Res Struct Biol, 4, 2022
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3L3N
 | | Testis ACE co-crystal structure with novel inhibitor lisW | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, CHLORIDE ION, ... | | 著者 | Watermeyer, J.M, Kroger, W.L, O'Neil, H.G, Sewell, B.T, Sturrock, E.D. | | 登録日 | 2009-12-17 | | 公開日 | 2010-04-28 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril.
Biochem.J., 428, 2010
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8P4I
 | | Cyanide dihydratase from Bacillus pumilus C1 | | 分子名称: | Cyanide dihydratase | | 著者 | Mulelu, A.E, Reitz, J, van Rooyen, J.M, Scheffer, M, Frangakis, A.S, Dlamini, L.S, Woodward, J.D, Benedik, M.J, Sewell, B.T. | | 登録日 | 2023-05-22 | | 公開日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (3.83 Å) | | 主引用文献 | The Role of Histidine Residues in the Oligomerization of Cyanide Dihydratase from Bacillus pumilus C1
To Be Published
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9ER3
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3BKL
 | | Testis ACE co-crystal structure with ketone ACE inhibitor kAW | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | 著者 | Watermeyer, J.M, Kroger, W.L, O'Neill, H.G, Sewell, B.T, Sturrock, E.D. | | 登録日 | 2007-12-07 | | 公開日 | 2008-06-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Probing the basis of domain-dependent inhibition using novel ketone inhibitors of Angiotensin-converting enzyme
Biochemistry, 47, 2008
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6ZBY
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3O6X
 | | Crystal Structure of the type III Glutamine Synthetase from Bacteroides fragilis | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Glutamine synthetase, ... | | 著者 | van Rooyen, J.M, Belrhali, H, Abratt, V.R, Sewell, B.T. | | 登録日 | 2010-07-29 | | 公開日 | 2011-03-09 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Crystal Structure of Type III Glutamine Synthetase: Surprising Reversal of the Inter-Ring Interface.
Structure, 19, 2011
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4APE
 | | THE ACTIVE SITE OF ASPARTIC PROTEINASES | | 分子名称: | ENDOTHIAPEPSIN | | 著者 | Pearl, L.H, Sewell, B.T, Jenkins, J.A, Cooper, J.B, Blundell, T.L. | | 登録日 | 1986-06-09 | | 公開日 | 1986-07-14 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The Active Site of Aspartic Proteinases
FEBS Lett., 174, 1984
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8C5I
 | | Cyanide dihydratase from Bacillus pumilus C1 variant - Q86R,H305K,H308K,H323K | | 分子名称: | Cyanide dihydratase | | 著者 | Mulelu, A.E, Reitz, J, van Rooyen, J, Scheffer, M, Frangakis, A.S, Dlamini, L.S, Woodward, J.D, Benedik, M.J, Sewell, B.T. | | 登録日 | 2023-01-09 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | | 主引用文献 | The Role of Histidine Residues in the Oligomerization of Cyanide Dihydratase from Bacillus pumilus C1
To Be Published
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2PLQ
 | | Crystal structure of the amidase from geobacillus pallidus RAPc8 | | 分子名称: | Aliphatic amidase | | 著者 | Kimani, S.W, Sewell, B.T, Agarkar, V.B, Sayed, M.F, Cowan, D.A. | | 登録日 | 2007-04-20 | | 公開日 | 2007-05-01 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The quaternary structure of the amidase from Geobacillus pallidus RAPc8 is
revealed by its crystal packing.
Acta Crystallogr.,Sect.F, 62, 2006
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3BKK
 | | Tesis ACE co-crystal structure with ketone ACE inhibitor kAF | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | | 著者 | Watermeyer, J.M, Kroger, W.L, O'Neill, H.G, Sewell, B.T, Sturrock, E.D. | | 登録日 | 2007-12-07 | | 公開日 | 2008-06-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Probing the basis of domain-dependent inhibition using novel ketone inhibitors of Angiotensin-converting enzyme
Biochemistry, 47, 2008
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2IUL
 | | Human tACE g13 mutant | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ANGIOTENSIN-CONVERTING ENZYME, ... | | 著者 | Watermeyer, J.M, Sewell, B.T, Natesh, R, Corradi, H.R, Acharya, K.R, Sturrock, E.D. | | 登録日 | 2006-06-06 | | 公開日 | 2006-10-25 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Structure of Testis Ace Glycosylation Mutants and Evidence for Conserved Domain Movement.
Biochemistry, 45, 2006
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7QOV
 | | The wild type nitrile hydratase from Geobacillus pallidus | | 分子名称: | CHLORIDE ION, COBALT (III) ION, Nitrile hydratase, ... | | 著者 | Van Wyk, J.C, Cowan, D.A, Danson, M.J, Tsekoa, T.L, Sayed, M.F, Sewell, B.T. | | 登録日 | 2021-12-29 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Engineering enhanced thermostability into the Geobacillus pallidus nitrile hydratase.
Curr Res Struct Biol, 4, 2022
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7QOU
 | | A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability | | 分子名称: | CHLORIDE ION, COBALT (II) ION, MAGNESIUM ION, ... | | 著者 | Van Wyk, J.C, Cowan, D.A, Danson, M.J, Tsekoa, T.L, Sayed, M.F, Sewell, B.T. | | 登録日 | 2021-12-29 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Engineering enhanced thermostability into the Geobacillus pallidus nitrile hydratase.
Curr Res Struct Biol, 4, 2022
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7QOY
 | | A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability | | 分子名称: | CHLORIDE ION, COBALT (III) ION, Nitrile hydratase, ... | | 著者 | Van Wyk, J.C, Cowan, D.A, Danson, M.J, Tsekoa, T.L, Sayed, M.F, Sewell, B.T. | | 登録日 | 2021-12-29 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability
To be published
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7QOP
 | | A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability | | 分子名称: | CHLORIDE ION, COBALT (II) ION, MAGNESIUM ION, ... | | 著者 | Van Wyk, J.C, Cowan, D.A, Danson, M.J, Tsekoa, T.L, Sayed, M.F, Sewell, B.T. | | 登録日 | 2021-12-24 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Engineering enhanced thermostability into the Geobacillus pallidus nitrile hydratase.
Curr Res Struct Biol, 4, 2022
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7QOM
 | | A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability | | 分子名称: | CHLORIDE ION, COBALT (II) ION, Nitrile hydratase, ... | | 著者 | Van Wyk, J.C, Cowan, D.A, Danson, M.J, Tsekoa, T.L, Sayed, M.F, Sewell, B.T. | | 登録日 | 2022-03-17 | | 公開日 | 2023-03-29 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability
To be published
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2DPP
 | | Crystal structure of thermostable Bacillus sp. RAPc8 nitrile hydratase | | 分子名称: | COBALT (II) ION, Nitrile hydratase alpha subunit, Nitrile hydratase beta subunit | | 著者 | Tsekoa, T.L, Tastan-Bishop, A.O, Cameron, R.A, Sewell, B.T, Sayed, M.F, Cowan, D.A. | | 登録日 | 2006-05-12 | | 公開日 | 2007-05-22 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Crystal structure of thermostable Bacillus sp. RAPc8 nitrile hydratse
To be Published
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6T1T
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6T1U
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4GYN
 | | The E142L mutant of the amidase from Geobacillus pallidus | | 分子名称: | Aliphatic amidase, CHLORIDE ION | | 著者 | Weber, B.W, Sewell, B.T, Kimani, S.W, Varsani, A, Cowan, D.A, Hunter, R. | | 登録日 | 2012-09-05 | | 公開日 | 2013-08-21 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning.
J.Biol.Chem., 288, 2013
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