3BKK

Tesis ACE co-crystal structure with ketone ACE inhibitor kAF

Summary for 3BKK

Entry DOI	10.2210/pdb3bkk/pdb
Related	1O86 1O8A 1UZE 1UZF 2IUL 2IUX 3BKL
Descriptor	Angiotensin-converting enzyme, somatic isoform, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	enzyme-inhibitor complex, gem-diol, domain-selective, carboxypeptidase, glycoprotein, hydrolase, membrane, metal-binding, metalloprotease, phosphoprotein, protease, secreted, transmembrane
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	69921.05
Authors	Watermeyer, J.M.,Kroger, W.L.,O'Neill, H.G.,Sewell, B.T.,Sturrock, E.D. (deposition date: 2007-12-07, release date: 2008-06-10, Last modification date: 2023-08-30)
Primary citation	Watermeyer, J.M.,Kroger, W.L.,O'Neill, H.G.,Sewell, B.T.,Sturrock, E.D. Probing the basis of domain-dependent inhibition using novel ketone inhibitors of Angiotensin-converting enzyme Biochemistry, 47:5942-5950, 2008 Cited by PubMed: 18457420 DOI: 10.1021/bi8002605 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.17 Å)

Structure validation