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PDB: 105 件
5TWL
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BU of 5twl by Molmil
Structure of Maternal Embryonic Leucine Zipper Kinase
分子名称: 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3,4-dihydropyrimido[5,4-c]quinolin-2(1H)-one, Maternal embryonic leucine zipper kinase
著者Seo, H.-S, Huang, H.-T, Gray, N.S, Dhe-Paganon, S.
登録日2016-11-14
公開日2017-11-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献MELK is not necessary for the proliferation of basal-like breast cancer cells.
Elife, 6, 2017
5TWY
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BU of 5twy by Molmil
Structure of Maternal Embryonic Leucine Zipper Kinase
分子名称: 2-(benzyloxy)-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide, Maternal embryonic leucine zipper kinase
著者Seo, H.-S, Dhe-Paganon, S.
登録日2016-11-15
公開日2017-11-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献MELK is not necessary for the proliferation of basal-like breast cancer cells.
Elife, 6, 2017
5TWZ
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BU of 5twz by Molmil
Structure of Maternal Embryonic Leucine Zipper Kinase
分子名称: 7-{[2-methoxy-4-(1H-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1H-3-benzazepinium, Maternal embryonic leucine zipper kinase
著者Seo, H.-Y, Dhe-Paganon, S.
登録日2016-11-15
公開日2017-11-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.631 Å)
主引用文献MELK is not necessary for the proliferation of basal-like breast cancer cells.
Elife, 6, 2017
7SZD
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BU of 7szd by Molmil
Crystal Structure Analysis of human PRPK complex with a compound
分子名称: 2-[(3R)-3-methyl-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid, EKC/KEOPS complex subunit TP53RK, EKC/KEOPS complex subunit TPRKB
著者Seo, H.-S, Dhe-Paganon, S.
登録日2021-11-27
公開日2022-12-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Development of PRPK Directed Phthalimides
Biorxiv, 2021
7SZC
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BU of 7szc by Molmil
Crystal Structure Analysis of human PRPK complex with a compound
分子名称: 4-hydroxy-2-[(3R)-3-methyl-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione, D(-)-TARTARIC ACID, EKC/KEOPS complex subunit TP53RK, ...
著者Seo, H.-S, Dhe-Paganon, S.
登録日2021-11-27
公開日2022-12-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Development of PRPK Directed Phthalimides
Biorxiv, 2021
7SZB
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BU of 7szb by Molmil
Crystal Structure Analysis of human PRPK complex with a compound
分子名称: 5-amino-2-[(3R)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione, CITRATE ANION, EKC/KEOPS complex subunit TP53RK, ...
著者Seo, H.-S, Dhe-Paganon, S.
登録日2021-11-27
公開日2023-01-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Development of PRPK Directed Phthalimides
Biorxiv, 2021
7SZA
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BU of 7sza by Molmil
Crystal Structure Analysis of human PRPK complex with a compound
分子名称: 4-amino-2-[(3R)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione, CITRATE ANION, EKC/KEOPS complex subunit TP53RK, ...
著者Seo, H.-S, Dhe-Paganon, S.
登録日2021-11-27
公開日2023-01-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Development of PRPK Directed Phthalimides
Biorxiv, 2021
8CUC
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BU of 8cuc by Molmil
Crystal structure analysis of SALL4 zinc finger domain in complex with DNA
分子名称: DNA (5'-D(P*CP*GP*AP*AP*AP*TP*AP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*TP*AP*TP*TP*TP*CP*G)-3'), Sal-like protein 4, ...
著者Seo, H.S, Dhe-Paganon, S.
登録日2022-05-17
公開日2023-05-24
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Crystal Structure Analysis of SALL4 Zinc Finger domain in complex with DNA
To Be Published
7MKX
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BU of 7mkx by Molmil
Crystal Structure Analysis of human CDK2 and CCNA2 complex
分子名称: 2-[(5-bromo-2-{4-[(cyanomethyl)sulfamoyl]anilino}pyrimidin-4-yl)amino]-6-fluorobenzamide, Cyclin-A2, Cyclin-dependent kinase 2
著者Seo, H.-S, Dhe-Paganon, S.
登録日2021-04-27
公開日2022-11-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献Crystal Structure Analysis of human CDK2 and CCNA2 complex
To Be Published
7U5W
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BU of 7u5w by Molmil
Crystal Structure Analysis of human Carbonic anhydrase 2
分子名称: Carbonic anhydrase 2, ZINC ION
著者Seo, H.-S, Dhe-Paganon, S.
登録日2022-03-02
公開日2023-03-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.13 Å)
主引用文献Crystal Structure Analysis of human Carbonic anhydrase 2
To Be Published
7U5X
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BU of 7u5x by Molmil
Crystal Structure Analysis of human Carbonic anhydrase 2
分子名称: Carbonic anhydrase 2, ZINC ION
著者Seo, H.-S, Dhe-Paganon, S.
登録日2022-03-02
公開日2023-03-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.04 Å)
主引用文献Crystal Structure Analysis of human Carbonic anhydrase 2
To Be Published
5TWX
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BU of 5twx by Molmil
Crystal Structure of BRD9 bromodomain
分子名称: Bromodomain-containing protein 9, N-[6-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)hexyl]-2-(4-{2-[N-(1,1-dioxo-1lambda~6~-thian-4-yl)carbamimidoyl]-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl}-2-methoxyphenoxy)acetamide
著者Seo, H.-S, Dhe-Paganon, S.
登録日2016-11-15
公開日2017-09-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.
Angew. Chem. Int. Ed. Engl., 56, 2017
6O34
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BU of 6o34 by Molmil
Crystal Structure Analysis of PIN1
分子名称: GLYCEROL, NONAETHYLENE GLYCOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ...
著者Seo, H.-S, Dhe-Paganon, S.
登録日2019-02-25
公開日2020-02-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Crystal Structure Analysis of PIN1
To be Published
6O33
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BU of 6o33 by Molmil
Crystal Structure Analysis of PIN1
分子名称: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION, peptide
著者Seo, H.-S, Dhe-Paganon, S.
登録日2019-02-25
公開日2020-02-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Crystal Structure Analysis of PIN1
To be Published
5WHH
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BU of 5whh by Molmil
Crystal Structure of Bcl-2-related protein A1 in complex with stapled peptide (AQ7)T(0EH)LRRFGD(MK8)INFRQ(NH2)
分子名称: (AQ7)T(0EH)LRRFGD(MK8)INFRQ(NH2), Bcl-2-related protein A1, CHLORIDE ION
著者Seo, H.-S, Dhe-Paganon, S.
登録日2017-07-17
公開日2018-01-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor.
Structure, 26, 2018
5VS6
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BU of 5vs6 by Molmil
Structure of DUB complex
分子名称: ACETATE ION, GLYCEROL, N-[3-({4-hydroxy-1-[(3R)-3-phenylbutanoyl]piperidin-4-yl}methyl)-4-oxo-3,4-dihydroquinazolin-7-yl]-3-(4-methylpiperazin-1-yl)propanamide, ...
著者Seo, H.-S, Dhe-Paganon, S.
登録日2017-05-11
公開日2017-12-20
最終更新日2018-01-03
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
5VSK
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BU of 5vsk by Molmil
Structure of DUB complex
分子名称: 7-chloro-3-({4-hydroxy-1-[(3S)-3-phenylbutanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one, Ubiquitin carboxyl-terminal hydrolase 7, ZINC ION
著者Seo, H.-Y, Dhe-Paganon, S.
登録日2017-05-11
公開日2017-12-20
最終更新日2018-01-03
実験手法X-RAY DIFFRACTION (3.33 Å)
主引用文献Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
3F7F
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BU of 3f7f by Molmil
Structure of Nup120
分子名称: MERCURY (II) ION, Nucleoporin NUP120
著者Seo, H.S, Ma, Y, Debler, E.W, Blobel, G, Hoelz, A.
登録日2008-11-08
公開日2009-08-18
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex.
Proc.Natl.Acad.Sci.USA, 106, 2009
5VSB
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BU of 5vsb by Molmil
Structure of DUB complex
分子名称: 7-chloro-3-{[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl}quinazolin-4(3H)-one, Ubiquitin carboxyl-terminal hydrolase 7
著者Seo, H.-S, Dhe-Paganon, S.
登録日2017-05-11
公開日2017-12-20
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
3H7N
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BU of 3h7n by Molmil
Structure of Nup120
分子名称: Nucleoporin NUP120
著者Seo, H.S, Ma, Y, Debler, E.W, Blobel, G, Hoelz, A.
登録日2009-04-27
公開日2009-08-18
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex.
Proc.Natl.Acad.Sci.USA, 106, 2009
7TUN
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BU of 7tun by Molmil
Crystal structure analysis of human CKB complex with a covalent compound
分子名称: (2S)-4-(chloroacetyl)-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide, Creatine kinase B-type
著者Seo, H.-S, Dhe-Paganon, S.
登録日2022-02-03
公開日2023-02-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.93 Å)
主引用文献Crystal Structure Analysis of human CKB complex with a covalent compound
To Be Published
7TUO
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BU of 7tuo by Molmil
Crystal structure analysis of human USP28 complex with a compound
分子名称: 7-amino-N-(2-{4-[(1R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yl]phenyl}ethyl)-3-methylthieno[2,3-b]pyrazine-6-carboxamide, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28
著者Seo, H.-S, Dhe-Paganon, S.
登録日2022-02-03
公開日2023-02-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Crystal Structure Analysis of human USP28 complex with a compound
To Be Published
6VQM
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BU of 6vqm by Molmil
Crystal Structure Analysis of human ACK1
分子名称: 2-({4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-2-methoxyphenyl}amino)-9-methyl-5,7-dihydro-6H-pyrimido[5,4-d][1,3]benzodiazepin-6-one, Activated CDC42 kinase 1, SULFATE ION
著者Seo, H.-S, Dhe-Paganon, S.
登録日2020-02-05
公開日2021-02-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Crystal Structure Analysis of human ACK1
To Be Published
6A6Q
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BU of 6a6q by Molmil
Crystal structure of a lignin peroxidase isozyme H8 variant that is stable at very acidic pH
分子名称: CALCIUM ION, GLYCEROL, HEME B/C, ...
著者Seo, H, Kim, K.-J, Pham, L.T.M.
登録日2018-06-29
公開日2019-01-23
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献In silico-designed lignin peroxidase fromPhanerochaete chrysosporiumshows enhanced acid stability for depolymerization of lignin.
Biotechnol Biofuels, 11, 2018
5TVT
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BU of 5tvt by Molmil
Structure of Maternal Embryonic Leucine Zipper Kinase
分子名称: 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one, Maternal embryonic leucine zipper kinase
著者Seo, H.-Y, Huang, H, Gray, N.S, Dhe-Paganon, S.
登録日2016-11-10
公開日2017-11-15
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Structure of Maternal Embryonic Leucine Zipper Kinase
To Be Published

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件を2024-06-12に公開中

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