4WI2
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![BU of 4wi2 by Molmil](/molmil-images/mine/4wi2) | Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc (wild-type) | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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4WI7
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![BU of 4wi7 by Molmil](/molmil-images/mine/4wi7) | Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation H435A | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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4WI8
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![BU of 4wi8 by Molmil](/molmil-images/mine/4wi8) | Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation Y436A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose, ... | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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4WI5
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![BU of 4wi5 by Molmil](/molmil-images/mine/4wi5) | Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation H310A | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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4WI3
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![BU of 4wi3 by Molmil](/molmil-images/mine/4wi3) | |
4WI6
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![BU of 4wi6 by Molmil](/molmil-images/mine/4wi6) | Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation N434A | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.201 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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4WI4
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![BU of 4wi4 by Molmil](/molmil-images/mine/4wi4) | Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation S254A | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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4WI9
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![BU of 4wi9 by Molmil](/molmil-images/mine/4wi9) | Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation I253A/H310A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region, ... | 著者 | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | 登録日 | 2014-09-25 | 公開日 | 2015-09-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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1S3K
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![BU of 1s3k by Molmil](/molmil-images/mine/1s3k) | Crystal Structure of a Humanized Fab (hu3S193) in Complex with the Lewis Y Tetrasaccharide | 分子名称: | GLYCEROL, HU3S193 Fab fragment, heavy chain, ... | 著者 | Ramsland, P.A, Farrugia, W, Bradford, T.M, Hogarth, P.M, Scott, A.M. | 登録日 | 2004-01-13 | 公開日 | 2004-07-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural convergence of antibody binding of carbohydrate determinants in lewis y tumor antigens J.Mol.Biol., 340, 2004
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6BZ4
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![BU of 6bz4 by Molmil](/molmil-images/mine/6bz4) | Human IgG1 lacking complement-dependent cytotoxicity: hu3S193 Fc mutant K322A | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Farrugia, W, Burvenich, I.G.J, Scott, A.M, Ramsland, P.A. | 登録日 | 2017-12-22 | 公開日 | 2018-06-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Global conformational changes in IgG-Fc upon mutation of the FcRn-binding site are not associated with altered antibody-dependent effector functions. Biochem. J., 475, 2018
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3RY6
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![BU of 3ry6 by Molmil](/molmil-images/mine/3ry6) | Complex of fcgammariia (CD32) and the FC of human IGG1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ig gamma-1 chain C region, ... | 著者 | Ramsland, P.A, Farrugia, W, Scott, A.M, Hogarth, P.M. | 登録日 | 2011-05-11 | 公開日 | 2011-08-31 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Structural Basis for Fc{gamma}RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes. J.Immunol., 187, 2011
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3EYV
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![BU of 3eyv by Molmil](/molmil-images/mine/3eyv) | Anti-Lewis Y Fab fragment with Lewis Y antigen in the presence of zinc ions | 分子名称: | GLYCEROL, ZINC ION, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-alpha-D-glucopyranose, ... | 著者 | Farrugia, W, Scott, A.M, Ramsland, P.A. | 登録日 | 2008-10-22 | 公開日 | 2009-11-03 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A possible role for metallic ions in the carbohydrate cluster recognition displayed by a lewis y specific antibody. Plos One, 4, 2009
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