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PDB: 57 件
4ULW
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Crystal structure of the ROQ-domain of human ROQUIN1
分子名称: ROQUIN-1
著者Schuetz, A, Heinemann, U.
登録日2014-05-14
公開日2015-01-14
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Roquin Binding to Target Mrnas Involves a Winged Helix-Turn- Helix Motif.
Nat.Commun., 5, 2014
8OMI
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BU of 8omi by Molmil
Crystal structure of the inositol hexakisphosphate kinase EhIP6KA M85 variant in complex with ATP and Mg2+
分子名称: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Schuetz, A, Aguirre, T, Fiedler, D.
登録日2023-03-31
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.
Elife, 12, 2023
6EKS
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BU of 6eks by Molmil
Vibrio cholerae neuraminidase complexed with oseltamivir carboxylate
分子名称: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, GLYCEROL, ...
著者Schuetz, A, Heinemann, U.
登録日2017-09-27
公開日2017-11-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Different Inhibitory Potencies of Oseltamivir Carboxylate, Zanamivir, and Several Tannins on Bacterial and Viral Neuraminidases as Assessed in a Cell-Free Fluorescence-Based Enzyme Inhibition Assay.
Molecules, 22, 2017
6EKU
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Vibrio cholerae neuraminidase complexed with zanamivir
分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Schuetz, A, Heinemann, U.
登録日2017-09-27
公開日2017-11-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Different Inhibitory Potencies of Oseltamivir Carboxylate, Zanamivir, and Several Tannins on Bacterial and Viral Neuraminidases as Assessed in a Cell-Free Fluorescence-Based Enzyme Inhibition Assay.
Molecules, 22, 2017
2WBU
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BU of 2wbu by Molmil
CRYSTAL STRUCTURE OF THE ZINC FINGER DOMAIN OF KLF4 BOUND TO ITS TARGET DNA
分子名称: 5'-D(*DGP*DAP*DGP*DGP*DCP*DGP*DTP* DGP*DGP*DC)-3', 5'-D(*DGP*DCP*DCP*DAP*DCP*DGP*DCP* DCP*DTP*DC)-3', KRUEPPEL-LIKE FACTOR 4, ...
著者Schuetz, A, Zocher, G, Carstanjen, D, Heinemann, U.
登録日2009-03-05
公開日2010-04-07
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Structure of the Klf4 DNA-Binding Domain Links to Self-Renewal and Macrophage Differentiation.
Cell.Mol.Life Sci., 68, 2011
5MR7
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BU of 5mr7 by Molmil
Crystal structure of the DBD domain of human Grhl2
分子名称: Grainyhead-like protein 2 homolog
著者Schuetz, A, Ming, Q, Roske, Y, Heinemann, U.
登録日2016-12-21
公開日2018-01-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Nucleic Acids Res., 46, 2018
3TT9
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BU of 3tt9 by Molmil
Crystal structure of the stable degradation fragment of human plakophilin 2 isoform a (PKP2a) C752R variant
分子名称: GLYCEROL, Plakophilin-2
著者Schuetz, A, Roske, Y, Gerull, B, Heinemann, U.
登録日2011-09-14
公開日2012-08-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations.
Circ Cardiovasc Genet, 5, 2012
5N7I
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BU of 5n7i by Molmil
Crystal structure of the coiled-coil domain of human tricellulin
分子名称: MARVEL domain-containing protein 2
著者Schuetz, A, Heinemann, U.
登録日2017-02-20
公開日2017-07-12
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization.
Ann. N. Y. Acad. Sci., 1405, 2017
5N7H
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Crystal structure of the coiled-coil domain of human tricellulin
分子名称: MARVEL domain-containing protein 2
著者Schuetz, A, Heinemann, U.
登録日2017-02-20
公開日2017-07-12
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization.
Ann. N. Y. Acad. Sci., 1405, 2017
5N7K
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BU of 5n7k by Molmil
Crystal structure of the coiled-coil domain of human tricellulin
分子名称: MARVEL domain-containing protein 2
著者Schuetz, A, Heinemann, U.
登録日2017-02-20
公開日2017-07-12
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization.
Ann. N. Y. Acad. Sci., 1405, 2017
8CJK
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BU of 8cjk by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-098
分子名称: 3-ethyl-8-[(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)methyl]-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1
著者Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
登録日2023-02-13
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.45914972 Å)
主引用文献Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
8CJJ
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Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-057
分子名称: 3-ethyl-7-(phenylmethyl)-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1
著者Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
登録日2023-02-13
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.66415656 Å)
主引用文献Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
8CJM
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Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-07-047
分子名称: 7-(cyclobutylmethyl)-3-ethyl-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1
著者Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
登録日2023-02-13
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
8CJI
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Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-07-052
分子名称: FE (III) ION, Tryptophan 5-hydroxylase 1, methyl (2~{S})-2-azanyl-3-[[3-[[3-ethyl-2,6-bis(oxidanylidene)-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purin-7-yl]methyl]phenyl]carbonylamino]propanoate
著者Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
登録日2023-02-13
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
8CJN
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BU of 8cjn by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-070
分子名称: 3-ethyl-7-[(4-phenylphenyl)methyl]-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1
著者Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
登録日2023-02-13
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.68080938 Å)
主引用文献Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
8CJL
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Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor TPT-004
分子名称: 3-ethyl-8-[(2-methyl-5~{H}-imidazo[2,1-b][1,3]thiazol-6-yl)methyl]-7-(oxetan-3-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1
著者Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
登録日2023-02-13
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
8CJO
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BU of 8cjo by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-004
分子名称: 1-[(3~{S})-3-(4-chloranyl-2-fluoranyl-phenyl)-1,4,8-triazatricyclo[7.4.0.0^{2,7}]trideca-2(7),8-dien-4-yl]-2-(2-ethyl-6-methyl-pyridin-3-yl)oxy-ethanone, FE (III) ION, Tryptophan 5-hydroxylase 1
著者Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
登録日2023-02-13
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.86633706 Å)
主引用文献Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
7ZIH
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BU of 7zih by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor AG-01-128
分子名称: 8-(1~{H}-benzimidazol-2-ylmethyl)-3-ethyl-7-(phenylmethyl)purine-2,6-dione, DI(HYDROXYETHYL)ETHER, FE (III) ION, ...
著者Schuetz, A, Gogolin, A, Pfeifer, J, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
登録日2022-04-08
公開日2022-09-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.46890831 Å)
主引用文献Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
7ZIK
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BU of 7zik by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor LP533401
分子名称: (2~{R})-2-azanyl-3-[4-[2-azanyl-6-[(1~{R})-1-[4-chloranyl-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-tris(fluoranyl)ethoxy]pyrimidin-4-yl]phenyl]propanoic acid, FE (III) ION, Tryptophan 5-hydroxylase 1
著者Schuetz, A, Heinemann, U.
登録日2022-04-08
公開日2022-09-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.58925915 Å)
主引用文献Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
7ZII
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Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-193
分子名称: 8-(5~{H}-[1,3]dioxolo[4,5-f]benzimidazol-6-ylmethyl)-7-(phenylmethyl)-3-propyl-purine-2,6-dione, FE (III) ION, GLYCEROL, ...
著者Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
登録日2022-04-08
公開日2022-09-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.6280005 Å)
主引用文献Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
7ZIJ
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Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-080
分子名称: 8-(1~{H}-benzimidazol-2-ylmethyl)-3-cyclopropyl-7-(phenylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1
著者Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
登録日2022-04-08
公開日2022-09-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.94678366 Å)
主引用文献Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
7ZIG
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BU of 7zig by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-060
分子名称: (2~{R})-2-azanyl-5-[[2-[[3-methyl-2,6-bis(oxidanylidene)-7-(phenylmethyl)purin-8-yl]methyl]-1~{H}-benzimidazol-5-yl]amino]-5-oxidanylidene-pentanoic acid, FE (III) ION, Tryptophan 5-hydroxylase 1
著者Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
登録日2022-04-08
公開日2022-09-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.808885 Å)
主引用文献Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
7ZIF
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BU of 7zif by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-480
分子名称: (2R)-2-azanyl-5-[[2-[3-methyl-2,6-bis(oxidanylidene)-7-(phenylmethyl)purin-8-yl]sulfanyl-3H-benzimidazol-5-yl]amino]-5-oxidanylidene-pentanoic acid, FE (III) ION, GLYCEROL, ...
著者Schuetz, A, Ziebart, N, Weise, M, Mallow, K, Pfeifer, J, Nazare, M, Specker, E, Heinemann, U.
登録日2022-04-08
公開日2022-09-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.86859715 Å)
主引用文献Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
2MVX
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Atomic-resolution 3D structure of amyloid-beta fibrils: the Osaka mutation
分子名称: Amyloid beta A4 protein
著者Schuetz, A.K, Vagt, T, Huber, M, Ovchinnikova, O.Y, Cadalbert, R, Wall, J, Guentert, P, Bockmann, A, Glockshuber, R, Meier, B.H.
登録日2014-10-17
公開日2014-11-26
最終更新日2024-05-01
実験手法SOLID-STATE NMR
主引用文献Atomic-Resolution Three-Dimensional Structure of Amyloid beta Fibrils Bearing the Osaka Mutation.
Angew.Chem.Int.Ed.Engl., 54, 2015
2PSW
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BU of 2psw by Molmil
Human MAK3 homolog in complex with CoA
分子名称: COENZYME A, N-acetyltransferase 13
著者Walker, J.R, Schuetz, A, Antoshenko, T, Wu, H, Bernstein, G, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
登録日2007-05-07
公開日2007-06-05
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of Human MAK3 homolog.
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