Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 14 件
4H7B
DownloadVisualize
BU of 4h7b by Molmil
Crystal Structure of Staphylococcal nuclease mutant I72V/V99L
分子名称: Thermonuclease
著者Sanders, J.M, Janowska, K, Sakon, J, Stites, W.E.
登録日2012-09-20
公開日2012-10-17
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Hydrophobic core mutants of Staphylococcal nuclease
To be Published
4K8J
DownloadVisualize
BU of 4k8j by Molmil
Crystal Structure of Staphylococcal nuclease mutant V23L/V66I
分子名称: Thermonuclease
著者Sanders, J.M, Gill, E, Roeser, J.R, Janowska, K, Sakon, J, Stites, W.E.
登録日2013-04-18
公開日2013-05-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Hydrophobic core mutants of Staphylococcal nuclease
To be Published
4K8I
DownloadVisualize
BU of 4k8i by Molmil
Crystal Structure of Staphylococcal Nuclease mutant I92V/V99L
分子名称: Thermonuclease
著者Sanders, J.M, Latimer, E.C, Roeser, J.R, Janowska, K, Sakon, J, Stites, W.E.
登録日2013-04-18
公開日2013-05-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Hydrophobic core mutants of Staphylococcal nuclease
To be Published
4XUC
DownloadVisualize
BU of 4xuc by Molmil
Synthesis and evaluation of heterocyclic catechol mimics as inhibitors of catechol-O-methyltransferase (COMT): Structure with Cmpd18 (1-(biphenyl-3-yl)-3-hydroxypyridin-4(1H)-one)
分子名称: 1-(biphenyl-3-yl)-3-hydroxypyridin-4(1H)-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Catechol O-methyltransferase, ...
著者Allison, T, Wolkenberg, S, Sanders, J.M, Soisson, S.M.
登録日2015-01-25
公開日2015-04-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).
Acs Med.Chem.Lett., 6, 2015
4XUD
DownloadVisualize
BU of 4xud by Molmil
Synthesis and evaluation of heterocyclic catechol mimics as inhibitors of catechol-O-methyltransferase (COMT): Structure with Cmpd32 ([1-(biphenyl-3-yl)-5-hydroxy-4-oxo-1,4-dihydropyridin-3-yl]boronic acid)
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Catechol O-methyltransferase, MAGNESIUM ION, ...
著者Allison, T, Wolkenberg, S, Sanders, J.M, Soisson, S.M.
登録日2015-01-25
公開日2015-04-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).
Acs Med.Chem.Lett., 6, 2015
4HHE
DownloadVisualize
BU of 4hhe by Molmil
Quinolinate synthase from Pyrococcus furiosus
分子名称: CHLORIDE ION, Quinolinate synthase A
著者Soriano, E.V, Zhang, Y, Settembre, E.C, Colabroy, K, Sanders, J.M, Dorrestein, P.C, Begley, T.P, Ealick, S.E.
登録日2012-10-09
公開日2013-08-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.797 Å)
主引用文献Active-site models for complexes of quinolinate synthase with substrates and intermediates.
Acta Crystallogr.,Sect.D, 69, 2013
4XUE
DownloadVisualize
BU of 4xue by Molmil
Synthesis and evaluation of heterocyclic catechol mimics as inhibitors of catechol-O-methyltransferase (COMT): Structure with Cmpd27b
分子名称: 2-(biphenyl-3-yl)-5-hydroxy-3-methylpyrimidin-4(3H)-one, Catechol O-methyltransferase, MAGNESIUM ION, ...
著者Allison, T, Wolkenberg, S, Sanders, J.M, Soisson, S.M.
登録日2015-01-25
公開日2015-04-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).
Acs Med.Chem.Lett., 6, 2015
6NM4
DownloadVisualize
BU of 6nm4 by Molmil
Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor
分子名称: 4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecane, Histone-lysine N-methyltransferase PRDM9, S-ADENOSYLMETHIONINE, ...
著者Ivanochko, D, Halabelian, L, Fischer, C, Sanders, J.M, Kattar, S.D, Brown, P.J, Edwards, A.M, Bountra, C, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
登録日2019-01-10
公開日2019-02-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Discovery of a chemical probe for PRDM9.
Nat Commun, 10, 2019
6VLM
DownloadVisualize
BU of 6vlm by Molmil
Core Catalytic Domain of HIV Integrase in complex with virtual screening hit
分子名称: Integrase, [3-(4-chlorophenyl)[1,3]thiazolo[3,2-a]benzimidazol-2-yl]acetic acid
著者Klein, D.J, Sanders, J.M.
登録日2020-01-24
公開日2020-05-13
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Augmenting Hit Identification by Virtual Screening Techniques in Small Molecule Drug Discovery.
J.Chem.Inf.Model., 60, 2020
5U6I
DownloadVisualize
BU of 5u6i by Molmil
Discovery of MLi-2, an Orally Available and Selective LRRK2 Inhibitor that Reduces Brain Kinase Activity
分子名称: 3-[2-(morpholin-4-yl)pyridin-4-yl]-5-[(propan-2-yl)oxy]-1H-indazole, Mitogen-activated protein kinase 1, SULFATE ION
著者Scott, J.D, DeMong, D.E, Fell, M.J, Mirescu, C, Basu, K, Greshock, T.J, Morrow, J.A, Xiao, L, Hruza, A, Harris, J, Tiscia, H.E, Chang, R.K, Embrey, M.W, McCauley, J.A, Li, W, Lin, S, Liu, H, Dai, X, Baptista, M, Agnihotri, G, Columbus, J, Mei, H, Poirier, M, Zhou, X, Lin, Y, Yin, Z, Sanders, J.M, Drolet, R.E, Kern, J.T, Kennedy, M.E, Parker, E.M, Stamford, A.W, Nargund, R, Miller, M.W.
登録日2016-12-08
公開日2017-03-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
J. Med. Chem., 60, 2017
1T1R
DownloadVisualize
BU of 1t1r by Molmil
Crystal Structure of the Reductoisomerase Complexed with a Bisphosphonate
分子名称: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, SULFATE ION, [(ISOQUINOLIN-1-YLAMINO)-PHOSPHONO-METHYL]-PHOSPHONIC ACID
著者Yajima, S, Hara, K, Sanders, J.M, Yin, F, Ohsawa, K, Wiesner, J, Jomaa, H, Oldfield, E.
登録日2004-04-17
公開日2004-09-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystallographic Structures of Two Bisphosphonate:1-Deoxyxylulose-5-Phosphate Reductoisomerase Complexes
J.Am.Chem.Soc., 126, 2004
1T1S
DownloadVisualize
BU of 1t1s by Molmil
Crystal Structure of the Reductoisomerase Complexed with a Bisphosphonate
分子名称: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, MAGNESIUM ION, SULFATE ION, ...
著者Yajima, S, Hara, K, Sanders, J.M, Yin, F, Ohsawa, K, Wiesner, J, Jomaa, H, Oldfield, E.
登録日2004-04-17
公開日2004-09-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystallographic Structures of Two Bisphosphonate:1-Deoxyxylulose-5-Phosphate Reductoisomerase Complexes
J.Am.Chem.Soc., 126, 2004
1TGV
DownloadVisualize
BU of 1tgv by Molmil
Structure of E. coli Uridine Phosphorylase complexed with 5-Fluorouridine and sulfate
分子名称: 5-FLUOROURIDINE, POTASSIUM ION, SULFATE ION, ...
著者Bu, W, Settembre, E.C, Sanders, J.M, Begley, T.P, Ealick, S.E.
登録日2004-05-31
公開日2005-06-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structures of E. coli Uridine Phosphorylase
To be Published, 2004
1TGY
DownloadVisualize
BU of 1tgy by Molmil
Structure of E. coli Uridine Phosphorylase complexed with uracil and ribose 1-phosphate
分子名称: 1-O-phosphono-alpha-D-ribofuranose, POTASSIUM ION, URACIL, ...
著者Bu, W, Settembre, E.C, Sanders, J.M, Begley, T.P, Ealick, S.E.
登録日2004-05-31
公開日2005-06-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structures of E. coli Uridine Phosphorylase
To be Published, 2004

221051

件を2024-06-12に公開中

PDB statisticsPDBj update infoContact PDBjnumon