8GCW
 
 | | Stx2A1(Y77A)-P6 peptide | | Descriptor: | P stalk protein, rRNA N-glycosylase | | Authors: | Rudolph, M.J, Li, X.P. | | Deposit date: | 2023-03-03 | | Release date: | 2024-03-06 | | Last modified: | 2024-09-18 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Fragment Screening to Identify Inhibitors Targeting Ribosome Binding of Shiga Toxin 2.
Acs Infect Dis., 10, 2024
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6OBG
 | | Ricin A chain bound to VHH antibody V8E6 | | Descriptor: | CHLORIDE ION, Ricin A chain, VHH antibody V8E6, ... | | Authors: | Rudolph, M.J. | | Deposit date: | 2019-03-20 | | Release date: | 2020-04-01 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.996 Å) | | Cite: | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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5U4L
 | | RTA-V1C7_G29R-high-salt | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, PHOSPHATE ION, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2016-12-05 | | Release date: | 2017-12-13 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies.
Proteins, 85, 2017
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9B88
 | | Anti-OspC Fab 8C1 | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Heavy Chain of monoclonal 8C1 Fab, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2024-03-29 | | Release date: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Structure of anti-OspC Fab 8C1.
To Be Published
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9BIF
 | | Fab B11-OspCA complex | | Descriptor: | CHLORIDE ION, Outer surface protein C, PRASEODYMIUM ION, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2024-04-23 | | Release date: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.09 Å) | | Cite: | Structure of a Human Monoclonal Antibody in Complex with Outer Surface Protein C of the Lyme Disease Spirochete, Borreliella burgdorferi.
J Immunol., 213, 2024
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4Z9K
 | | Ricin A chain bound to camelid nanobody (VHH2)(F5) | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin, ... | | Authors: | Rudolph, M.J. | | Deposit date: | 2015-04-10 | | Release date: | 2016-07-20 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit.
Proteins, 84, 2016
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2NYE
 | | Crystal structure of the Bateman2 domain of yeast Snf4 | | Descriptor: | Nuclear protein SNF4 | | Authors: | Rudolph, M.J, Amodeo, G.A, Iram, S, Hong, S, Pirino, G, Carlson, M, Tong, L. | | Deposit date: | 2006-11-20 | | Release date: | 2006-12-12 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding.
Structure, 15, 2007
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2NYC
 | | Crystal structure of the Bateman2 domain of yeast Snf4 | | Descriptor: | Nuclear protein SNF4 | | Authors: | Rudolph, M.J, Amodeo, G.A, Iram, S, Hong, S, Pirino, G, Carlson, M, Tong, L. | | Deposit date: | 2006-11-20 | | Release date: | 2006-12-12 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding.
Structure, 15, 2007
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6CWK
 | | Anti-RTA VHH antibody | | Descriptor: | 1,2-ETHANEDIOL, Anti-Ricin antibody, CHLORIDE ION, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2018-03-30 | | Release date: | 2019-01-16 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.256 Å) | | Cite: | Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity.
Protein Eng. Des. Sel., 31, 2018
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6CWG
 | | Ricin catalytic subunit bound go A9 VHH antibody | | Descriptor: | CHLORIDE ION, Ricin, VHH antibody | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2018-03-30 | | Release date: | 2019-01-16 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity.
Protein Eng. Des. Sel., 31, 2018
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9E40
 | | RTA-RUNT-202 complex | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-(4-fluoro-2,6-dimethylphenyl)thiophene-2-carboxylic acid, CHLORIDE ION, ... | | Authors: | Rudolph, M.J, Tumer, N. | | Deposit date: | 2024-10-24 | | Release date: | 2025-05-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Binding of small molecules at the P-stalk site of ricin A subunit trigger conformational changes that extend into the active site.
J.Biol.Chem., 301, 2025
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9E3T
 | | RTA-RUNT-165 complex | | Descriptor: | (5M)-5-(2-ethyl-6-methylphenyl)thiophene-2-carboxylic acid, CHLORIDE ION, Ricin A chain | | Authors: | Rudolph, M.J, Tumer, N. | | Deposit date: | 2024-10-24 | | Release date: | 2025-05-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Binding of small molecules at the P-stalk site of ricin A subunit trigger conformational changes that extend into the active site.
J.Biol.Chem., 301, 2025
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9E42
 | | RTA-RUNT-192 complex | | Descriptor: | 1,2-ETHANEDIOL, 5-(2,6-diethylphenyl)thiophene-2-carboxylic acid, Ricin A chain | | Authors: | Rudolph, M.J, Tumer, N. | | Deposit date: | 2024-10-24 | | Release date: | 2025-05-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Binding of small molecules at the P-stalk site of ricin A subunit trigger conformational changes that extend into the active site.
J.Biol.Chem., 301, 2025
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5BOZ
 | | Ricin A chain bound to camelid nanobody (VHH9)(E1) | | Descriptor: | CHLORIDE ION, Ricin, SULFATE ION, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2015-05-27 | | Release date: | 2016-12-07 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural Analysis of Single Domain Antibodies Bound to a Second Neutralizing Hot Spot on Ricin Toxin's Enzymatic Subunit.
J. Biol. Chem., 292, 2017
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7UJ2
 | | OspC Type B | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Outer surface protein C | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2022-03-30 | | Release date: | 2023-04-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.503 Å) | | Cite: | Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi.
Mbio, 14, 2023
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7UJ6
 | | Outer Surface Protein C Type K | | Descriptor: | Outer surface protein C | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2022-03-30 | | Release date: | 2023-04-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.951 Å) | | Cite: | Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi.
Mbio, 14, 2023
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7UIJ
 | | Structural studies of B5-OspC complex | | Descriptor: | 1,2-ETHANEDIOL, Monoclonal B5 Fab Heavy Chain, Monoclonal B5 Fab Light Chain, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2022-03-29 | | Release date: | 2023-04-05 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.701 Å) | | Cite: | Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi.
Mbio, 14, 2023
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3HYH
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6X6H
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5E1H
 | | Ricin toxin in complex with neutralizing single chain monoclonal antibodies (VHHs) | | Descriptor: | CHLORIDE ION, F8(JOB10) VHH antibody, Ricin | | Authors: | Rudolph, M.J, Vance, D, Shoemaker, C, Mantis, N. | | Deposit date: | 2015-09-29 | | Release date: | 2016-08-03 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.032 Å) | | Cite: | Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit.
Proteins, 84, 2016
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4LGR
 | | Ricin A chain bound to camelid nanobody (VHH3) | | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ... | | Authors: | Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N. | | Deposit date: | 2013-06-28 | | Release date: | 2014-06-11 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
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4LHJ
 | | Ricin A chain bound to camelid nanobody (VHH5) | | Descriptor: | CHLORIDE ION, Camelid antibody, Ricin | | Authors: | Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N. | | Deposit date: | 2013-07-01 | | Release date: | 2014-06-11 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
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6OCD
 | | Ricin A chain bound to VHH antibody V6D4 | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, IMIDAZOLE, ... | | Authors: | Rudolph, M.J. | | Deposit date: | 2019-03-22 | | Release date: | 2020-04-01 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.103 Å) | | Cite: | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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4LGS
 | | Ricin A chain bound to camelid nanobody (VHH4) | | Descriptor: | Camelid nanobody (VHH4), Ricin | | Authors: | Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N. | | Deposit date: | 2013-06-28 | | Release date: | 2014-06-11 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
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4LGP
 | | Ricin A chain bound to camelid nanobody (VHH1) | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin, ... | | Authors: | Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N. | | Deposit date: | 2013-06-28 | | Release date: | 2014-06-11 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
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