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PDB: 119 件

1DQZ
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CRYSTAL STRUCTURE OF ANTIGEN 85C FROM MYCOBACTERIUM TUBERCULOSIS
分子名称: PROTEIN (ANTIGEN 85-C)
著者Ronning, D.R, Klabunde, T, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2000-01-05
公開日2000-07-12
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.
Nat.Struct.Biol., 7, 2000
1DQY
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CRYSTAL STRUCTURE OF ANTIGEN 85C FROM MYCOBACTERIUM TUBERCULOSIS WITH DIETHYL PHOSPHATE INHIBITOR
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, DIETHYL PHOSPHONATE, PROTEIN (ANTIGEN 85-C)
著者Ronning, D.R, Klabunde, T, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2000-01-05
公開日2000-07-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.
Nat.Struct.Biol., 7, 2000
1VA5
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Antigen 85C with octylthioglucoside in active site
分子名称: Antigen 85-C, octyl 1-thio-beta-D-glucopyranoside
著者Ronning, D.R, Vissa, V, Besra, G.S, Belisle, J.T, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2004-02-11
公開日2004-07-06
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Mycobacterium tuberculosis Antigen 85A and 85C Structures Confirm Binding Orientation and Conserved Substrate Specificity
J.Biol.Chem., 279, 2004
4U31
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Sco GlgEI-V279S in Complex with maltose-C-phosphonate
分子名称: 1,2-ETHANEDIOL, Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 1, CITRIC ACID, ...
著者Ronning, D.R, Lindenberger, J.J.
登録日2014-07-18
公開日2015-07-22
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.849 Å)
主引用文献Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors.
Sci Rep, 5, 2015
4U33
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Structure of Mtb GlgE bound to maltose
分子名称: Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Ronning, D.R, Lindenberger, J.J.
登録日2014-07-18
公開日2015-07-22
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.293 Å)
主引用文献Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors.
Sci Rep, 5, 2015
4U3C
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Docking Site of Maltohexaose in the Mtb GlgE
分子名称: Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Ronning, D.R, Lindenberger, J.J.
登録日2014-07-19
公開日2015-07-22
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.98 Å)
主引用文献Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors.
Sci Rep, 5, 2015
4U2Z
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X-ray crystal structure of an Sco GlgEI-V279S/1,2,2-trifluromaltose complex
分子名称: Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 1, alpha-D-glucopyranose-(1-4)-2-deoxy-2,2-difluoro-alpha-D-arabino-hexopyranosyl fluoride
著者Ronning, D.R, Lindenberger, J.J.
登録日2014-07-18
公開日2015-07-22
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Synthesis of 2-deoxy-2,2-difluoro-alpha-maltosyl fluoride and its X-ray structure in complex with Streptomyces coelicolor GlgEI-V279S.
Org.Biomol.Chem., 13, 2015
4U2Y
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Sco GlgEI-V279S in Complex with Reaction Intermediate Azasugar
分子名称: (2R,3R,4R,5R)-4-hydroxy-2,5-bis(hydroxymethyl)pyrrolidin-3-yl alpha-D-glucopyranoside, Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 1
著者Ronning, D.R, Lindenberger, J.J.
登録日2014-07-18
公開日2015-08-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.483 Å)
主引用文献Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors.
Sci Rep, 5, 2015
1T0F
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Crystal Structure of the TnsA/TnsC(504-555) complex
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, MALONIC ACID, ...
著者Ronning, D.R, Li, Y, Perez, Z.N, Ross, P.D, Hickman, A.B, Craig, N.L, Dyda, F.
登録日2004-04-08
公開日2004-11-09
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The carboxy-terminal portion of TnsC activates the Tn7 transposase through a specific interaction with TnsA.
Embo J., 23, 2004
3NM5
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Helicobacter pylori MTAN complexed with Formycin A
分子名称: (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, MTA/SAH nucleosidase
著者Ronning, D.R, Iacopelli, N.M.
登録日2010-06-21
公開日2010-11-24
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Protein Sci., 19, 2010
1SFR
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Crystal Structure of the Mycobacterium tuberculosis Antigen 85A Protein
分子名称: Antigen 85-A
著者Ronning, D.R, Vissa, V, Besra, G.S, Belisle, J.T, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2004-02-20
公開日2004-07-06
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Mycobacterium tuberculosis Antigen 85A and 85C Structures Confirm Binding Orientation and Conserved Substrate Specificity
J.Biol.Chem., 279, 2004
3NM6
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Helicobacter pylori MTAN complexed with adenine and tris
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENINE, ...
著者Ronning, D.R, Iacopelli, N.M.
登録日2010-06-21
公開日2010-11-24
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.602 Å)
主引用文献Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Protein Sci., 19, 2010
3NM4
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Helicobacter pylori MTAN
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MTA/SAH nucleosidase
著者Ronning, D.R, Iacopelli, N.M.
登録日2010-06-21
公開日2010-11-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Protein Sci., 19, 2010
2A6O
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Crystal Structure of the ISHp608 Transposase in Complex with Stem-loop DNA
分子名称: 5'-D(*CP*CP*CP*CP*TP*AP*GP*CP*TP*TP*TP*AP*GP*CP*TP*AP*TP*GP*GP*GP*GP*A)-3', ISHp608 Transposase
著者Ronning, D.R, Guynet, C, Ton-Hoang, B, Perez, Z.N, Ghirlando, R, Chandler, M, Dyda, F.
登録日2005-07-03
公開日2005-10-25
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Active site sharing and subterminal hairpin recognition in a new class of DNA transposases.
Mol.Cell, 20, 2005
2A6M
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Crystal Structure of the ISHp608 Transposase
分子名称: ISHp608 transposase
著者Ronning, D.R, Guynet, C, Ton-Hoang, B, Perez, Z.N, Ghirlando, R, Chandler, M, Dyda, F.
登録日2005-07-03
公開日2005-10-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Active site sharing and subterminal hairpin recognition in a new class of DNA transposases.
Mol.Cell, 20, 2005
4P54
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Crystal Structure of the Helicobacter pylori MTAN-D198N mutant with 5'-methylthioadenosine in the active site.
分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Aminodeoxyfutalosine nucleosidase, CHLORIDE ION
著者Ronning, D.R, Mishra, V.
登録日2014-03-14
公開日2014-04-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structures of the Helicobacter pylori MTAN enzyme reveal specific interactions between S-adenosylhomocysteine and the 5'-alkylthio binding subsite.
Biochemistry, 51, 2012
4MQL
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Crystal structure of Antigen 85C-C209S mutant
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Diacylglycerol acyltransferase/mycolyltransferase Ag85C
著者Favrot, L, Grzegorzewicz, A.E, Lajiness, D.H, Marvin, R.K, Boucau, J, Isailovic, D, Jackson, M, Ronning, D.R.
登録日2013-09-16
公開日2013-11-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen.
Nat Commun, 4, 2013
8D6K
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Sco GlgEI-V279S in complex with cyclohexyl carbasugar
分子名称: (1R,4S,5S,6R)-4-(cyclohexylamino)-5,6-dihydroxy-2-(hydroxymethyl)cyclohex-2-en-1-yl alpha-D-glucopyranoside, Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 1, DI(HYDROXYETHYL)ETHER
著者Jayasinghe, T.J, Ronning, D.R.
登録日2022-06-06
公開日2022-10-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Synthesis of C 7 /C 8 -cyclitols and C 7 N-aminocyclitols from maltose and X-ray crystal structure of Streptomyces coelicolor GlgEI V279S in a complex with an amylostatin GXG-like derivative.
Front Chem, 10, 2022
3HRH
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Crystal Structure of Antigen 85C and Glycerol
分子名称: Antigen 85-C, GLYCEROL
著者Boucau, J, Sanki, A.K, Umesiri, F.E, Sucheck, S.J, Ronning, D.R.
登録日2009-06-09
公開日2009-09-29
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Design, synthesis and biological evaluation of sugar-derived esters, alpha-ketoesters and alpha-ketoamides as inhibitors for Mycobacterium tuberculosis antigen 85C.
Mol Biosyst, 5, 2009
8F5V
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Crystal structure of Mycobacterium tuberculosis Mycothiol S-transferase enzyme in complex with mycothiol and Zn2+
分子名称: Conserved protein, Mycothiol, ZINC ION
著者Jayasinghe, Y.P, Ronning, D.R.
登録日2022-11-15
公開日2023-04-05
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献The Mycobacterium tuberculosis mycothiol S -transferase is divalent metal-dependent for mycothiol binding and transfer.
Rsc Med Chem, 14, 2023
8F2L
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Crystal structure of Mycobacterium tuberculosis Homoserine transacetylase in complex with L-Homoserine
分子名称: Homoserine O-acetyltransferase, L-HOMOSERINE
著者Jayasinghe, Y.P, Ronning, D.R.
登録日2022-11-08
公開日2023-03-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Structural and Functional Characterization of Mycobacterium tuberculosis Homoserine Transacetylase.
Acs Infect Dis., 9, 2023
1UUT
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The Nuclease Domain of Adeno-Associated Virus Rep Complexed with the RBE' Stemloop of the Viral Inverted Terminal Repeat
分子名称: 5'-D(*CP*AP*GP*CP*TP*CP*TP*TP*TP*GP *AP*GP*CP*TP*G)-3', CHLORIDE ION, MAGNESIUM ION, ...
著者Dyda, F, Hickman, A.B, Ronning, D.R, Perez, Z.N, Kotin, R.M.
登録日2004-01-10
公開日2004-02-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Nuclease Domain of Adeno-Associated Virus Rep Coordinates Replication Initiation Using Two Distinct DNA Recognition Interfaces
Mol.Cell, 13, 2004
8FX9
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Crystal strucutre of Mycobacterium tuberculosis Mycothiol-S-transferase enzyme
分子名称: CHLORIDE ION, Mycothiol-S-transferase
著者Lindenberger, J.J, Jayasinghe, Y.P, Ronning, D.R.
登録日2023-01-24
公開日2023-04-05
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献The Mycobacterium tuberculosis mycothiol S -transferase is divalent metal-dependent for mycothiol binding and transfer.
Rsc Med Chem, 14, 2023
5CCE
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Joint X-ray/neutron structure of wild type MTAN complexed with SRH and adenine
分子名称: 5'-Methylthioadenosine Nucleosidase, ADENINE, S-ribosylhomocysteine, ...
著者Banco, M.T, Kovalevsky, A.Y, Ronning, D.R.
登録日2015-07-02
公開日2016-11-16
最終更新日2023-09-27
実験手法NEUTRON DIFFRACTION (2.5 Å), X-RAY DIFFRACTION
主引用文献Neutron structures of the Helicobacter pylori 5'-methylthioadenosine nucleosidase highlight proton sharing and protonation states.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
8S9D
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C143S variant of Citrate Synthase (CitA) in Mycobacterium tuberculosis
分子名称: 1,2-ETHANEDIOL, CITRATE ANION, citrate synthase
著者Pathirage, R, Ronning, D.
登録日2023-03-27
公開日2023-06-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding.
Rsc Med Chem, 14, 2023

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