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PDB: 12 件
2MG6
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Non-reducible analogues of alpha-conotoxin Vc1.1: [3,16]-trans dicarba Vc1.1
分子名称: Alpha-conotoxin Vc1A
著者Robinson, S.D, Macraild, C.A, Van Lierop, B.J, Robinson, A.J, Norton, R.S.
登録日2013-10-28
公開日2013-12-18
実験手法SOLUTION NMR
主引用文献Dicarba alpha-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors.
Acs Chem.Biol., 8, 2013
2MFX
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Non-reducible analogues of alpha-conotoxin Vc1.1: [2,8]-cis dicarba Vc1.1
分子名称: Alpha-conotoxin Vc1A
著者Robinson, S.D, Macraild, C.A, Van Lierop, B.J, Robinson, A.J, Norton, R.S.
登録日2013-10-24
公開日2013-12-18
実験手法SOLUTION NMR
主引用文献Dicarba alpha-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors.
Acs Chem.Biol., 8, 2013
2MFY
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Non-reducible analogues of alpha-conotoxin Vc1.1: [2,8]-trans dicarba Vc1.1
分子名称: Alpha-conotoxin Vc1A
著者Robinson, S.D, Macraild, C.A, Van Lierop, B.J, Robinson, A.J, Norton, R.S.
登録日2013-10-24
公開日2013-12-18
実験手法SOLUTION NMR
主引用文献Dicarba alpha-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors.
Acs Chem.Biol., 8, 2013
2N24
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Solution NMR structure of Contryphan-Vc1
分子名称: O2_contryphan_Vc1
著者Robinson, S.D, Chhabra, S, Norton, R.S.
登録日2015-04-27
公開日2016-02-03
最終更新日2024-10-30
実験手法SOLUTION NMR
主引用文献A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed beta-Hairpin Fold.
Structure, 24, 2016
7R6P
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Solution structure of peptide toxin MIITX2-Mg1a from the venom of the Australian giant red bull ant Myrmecia gulosa
分子名称: U-myrmeciitoxin(02)-Mg1a
著者Chin, Y.K, Eagle, D, Bankala, K, Robinson, S.D.
登録日2021-06-23
公開日2022-02-09
最終更新日2024-10-23
実験手法SOLUTION NMR
主引用文献A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals.
Proc.Natl.Acad.Sci.USA, 119, 2022
5KKM
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Con-Vc11-22
分子名称: O2_contryphan_Vc1 prepropeptide
著者Chittoor, B, Krishnarjuna, B, MacRaild, C.A, Robinson, S.D.
登録日2016-06-22
公開日2017-05-31
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献The Single Disulfide-Directed beta-Hairpin Fold. Dynamics, Stability, and Engineering.
Biochemistry, 56, 2017
2MTO
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Non-reducible analogues of alpha-conotoxin RgIA: [2,8]-cis dicarba RgIA
分子名称: Alpha-conotoxin RgIA
著者Chhabra, S, Robinson, S, Norton, R.
登録日2014-08-26
公開日2014-11-26
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets.
J.Med.Chem., 57, 2014
5F4N
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Multi-parameter lead optimization to give an oral CHK1 inhibitor clinical candidate: (R)-5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Serine/threonine-protein kinase Chk1, ...
著者Collins, I, Garrett, M.D, van Montfort, R, Osborne, J.D, Matthews, T.P, McHardy, T, Proisy, N, Cheung, K.J, Lainchbury, M, Brown, N, Walton, M.I, Eve, P.D, Boxall, K.J, Hayes, A, Henley, A.T, Valenti, M.R, De Haven Brandon, A.K, Box, G, Westwood, I.M, Jamin, Y, Robinson, S.P, Leonard, P, Reader, J.C, Aherne, G.W, Raynaud, F.I, Eccles, S.A.
登録日2015-12-03
公開日2016-05-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737).
J.Med.Chem., 59, 2016
7KNN
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Solution structure of the alpha-conotoxin analogue [2-8]-alkyne Vc1.1
分子名称: Alpha-conotoxin Vc1a
著者MacRaild, C.A, Robinson, S.D, Chhabra, S, Norton, R.S.
登録日2020-11-05
公開日2021-09-15
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Alkyne-Bridged alpha-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models.
J.Med.Chem., 64, 2021
2MTT
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Non-reducible analogues of alpha-conotoxin RgIA: [3,12]-cis dicarba RgIA
分子名称: Dicarba Analogues of alpha-Conotoxin RgIA
著者Chhabra, S, Robinson, S.D, Norton, R.S.
登録日2014-08-31
公開日2014-11-26
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets.
J.Med.Chem., 57, 2014
2MTU
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Non-reducible analogues of alpha-conotoxin RgIA: [3,12]-trans dicarba RgIA
分子名称: Dicarba Analogues of alpha-Conotoxin RgIA
著者Chhabra, S, Robinson, S.D, Norton, R.S.
登録日2014-09-01
公開日2014-11-26
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets.
J.Med.Chem., 57, 2014
1E3B
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CYCLOPHILIN 3 FROM C.ELEGANS COMPLEXED WITH AUP(ET)3
分子名称: CYCLOPHILIN 3, GOLD ION, TRIETHYLPHOSPHANE
著者Zou, J, Taylor, P, Dornan, J, Robinson, S.P, Walkinshaw, M.D, Sadler, P.J.
登録日2000-06-08
公開日2000-10-22
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献First Crystal Structure of a Medicinally Relevant Gold Protein Complex:Unexpected Binding of [Au(Pet (3))](+) to Histidine
Angew.Chem.Int.Ed.Engl., 39, 2000

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件を2024-10-30に公開中

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