3V16
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![BU of 3v16 by Molmil](/molmil-images/mine/3v16) | An intramolecular pi-cation latch in phosphatidylinositol-specific phospholipase C from S.aureus controls substrate access to the active site | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, CHLORIDE ION | 著者 | Goldstein, R.I, Cheng, J, Stec, B, Roberts, M.F. | 登録日 | 2011-12-09 | 公開日 | 2012-04-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure of the S. aureus PI-Specific Phospholipase C Reveals Modulation of Active Site Access by a Titratable PI-Cation Latched Loop Biochemistry, 51, 2012
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3QVT
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![BU of 3qvt by Molmil](/molmil-images/mine/3qvt) | L-myo-inositol 1-phosphate synthase from Archaeoglobus fulgidus wild-type with the intermediate 5-keto 1-phospho glucose | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, Myo-inositol-1-phosphate synthase (Ino1), ... | 著者 | Neelon, K, Roberts, M.F, Stec, B. | 登録日 | 2011-02-25 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of a trapped catalytic intermediate suggests that forced atomic proximity drives the catalysis of mIPS. Biophys.J., 101, 2011
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3QVX
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![BU of 3qvx by Molmil](/molmil-images/mine/3qvx) | L-myo-inositol 1-phosphate synthase from Archaeoglobus fulgidus mutant K367A | 分子名称: | GLYCEROL, Myo-inositol-1-phosphate synthase (Ino1), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Neelon, K, Roberts, M.F, Stec, B. | 登録日 | 2011-02-26 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of a trapped catalytic intermediate suggests that forced atomic proximity drives the catalysis of mIPS. Biophys.J., 101, 2011
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1LBV
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![BU of 1lbv by Molmil](/molmil-images/mine/1lbv) | Crystal Structure of apo-form (P21) of dual activity FBPase/IMPase (AF2372) from Archaeoglobus fulgidus | 分子名称: | fructose 1,6-bisphosphatase/inositol monophosphatase | 著者 | Stieglitz, K.A, Johnson, K.A, Yang, H, Roberts, M.F, Seaton, B.A, Head, J.F, Stec, B. | 登録日 | 2002-04-04 | 公開日 | 2002-05-22 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop. J.Biol.Chem., 277, 2002
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2OR2
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![BU of 2or2 by Molmil](/molmil-images/mine/2or2) | Structure of the W47A/W242A Mutant of Bacterial Phosphatidylinositol-Specific Phospholipase C | 分子名称: | 1-phosphatidylinositol phosphodiesterase | 著者 | Shao, C, Shi, X, Wehbi, H, Zambonelli, C, Head, J.F, Seaton, B.A, Roberts, M.F. | 登録日 | 2007-02-01 | 公開日 | 2007-02-13 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Dimer structure of an interfacially impaired phosphatidylinositol-specific phospholipase C. J.Biol.Chem., 282, 2007
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1LBW
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![BU of 1lbw by Molmil](/molmil-images/mine/1lbw) | Crystal Structure of apo-form (P32) of dual activity FBPase/IMPase (AF2372) from Archaeoglobus fulgidus | 分子名称: | fructose 1,6-bisphosphatase/inositol monophosphatase | 著者 | Stieglitz, K.A, Johnson, K.A, Yang, H, Roberts, M.F, Seaton, B.A, Head, J.F, Stec, B. | 登録日 | 2002-04-04 | 公開日 | 2002-05-22 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop. J.Biol.Chem., 277, 2002
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1LBX
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![BU of 1lbx by Molmil](/molmil-images/mine/1lbx) | Crystal Structure of a ternary complex of dual activity FBPase/IMPase (AF2372) from Archaeoglobus fulgidus with Calcium ions and D-myo-Inositol-1-Phosphate | 分子名称: | CALCIUM ION, D-MYO-INOSITOL-1-PHOSPHATE, fructose 1,6-bisphosphatase/inositol monophosphatase | 著者 | Stieglitz, K.A, Johnson, K.A, Yang, H, Roberts, M.F, Seaton, B.A, Head, J.F, Stec, B. | 登録日 | 2002-04-04 | 公開日 | 2002-05-22 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop. J.Biol.Chem., 277, 2002
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1LBZ
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![BU of 1lbz by Molmil](/molmil-images/mine/1lbz) | Crystal Structure of a complex (P32 crystal form) of dual activity FBPase/IMPase (AF2372) from Archaeoglobus fulgidus with 3 Calcium ions and Fructose-1,6 bisphosphate | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, CALCIUM ION, fructose 1,6-bisphosphatase/inositol monophosphatase | 著者 | Stieglitz, K.A, Johnson, K.A, Yang, H, Roberts, M.F, Seaton, B.A, Head, J.F, Stec, B. | 登録日 | 2002-04-04 | 公開日 | 2002-05-22 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop. J.Biol.Chem., 277, 2002
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1U1I
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![BU of 1u1i by Molmil](/molmil-images/mine/1u1i) | Myo-inositol phosphate synthase mIPS from A. fulgidus | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PHOSPHATE ION, POTASSIUM ION, ... | 著者 | Stieglitz, K.A, Yang, H, Roberts, M.F, Stec, B. | 登録日 | 2004-07-15 | 公開日 | 2004-08-10 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Reaching for Mechanistic Consensus Across Life Kingdoms: Structure and Insights into Catalysis of the myo-Inositol-1-phosphate Synthase (mIPS) from Archaeoglobus fulgidus Biochemistry, 44, 2005
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4F2U
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![BU of 4f2u by Molmil](/molmil-images/mine/4f2u) | Structure of the N254Y/H258Y double mutant of the Phosphatidylinositol-Specific Phospholipase C from S.aureus | 分子名称: | 1-phosphatidylinositol phosphodiesterase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION | 著者 | Cheng, J, Goldstein, R, Stec, B, Gershenson, A, Roberts, M.F. | 登録日 | 2012-05-08 | 公開日 | 2012-12-12 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity. J.Biol.Chem., 287, 2012
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1DK4
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![BU of 1dk4 by Molmil](/molmil-images/mine/1dk4) | CRYSTAL STRUCTURE OF MJ0109 GENE PRODUCT INOSITOL MONOPHOSPHATASE | 分子名称: | INOSITOL MONOPHOSPHATASE, PHOSPHATE ION, ZINC ION | 著者 | Stec, B, Yang, H, Johnson, K.A, Chen, L, Roberts, M.F. | 登録日 | 1999-12-06 | 公開日 | 2000-11-08 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | MJ0109 is an enzyme that is both an inositol monophosphatase and the 'missing' archaeal fructose-1,6-bisphosphatase. Nat.Struct.Biol., 7, 2000
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3V18
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![BU of 3v18 by Molmil](/molmil-images/mine/3v18) | Structure of the Phosphatidylinositol-specific phospholipase C from Staphylococcus aureus | 分子名称: | 1-phosphatidylinositol phosphodiesterase, ISOPROPYL ALCOHOL, SULFATE ION | 著者 | Goldstein, R.I, Cheng, J, Stec, B, Roberts, M.F. | 登録日 | 2011-12-09 | 公開日 | 2012-04-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Structure of the S. aureus PI-Specific Phospholipase C Reveals Modulation of Active Site Access by a Titratable PI-Cation Latched Loop Biochemistry, 51, 2012
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3V1H
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![BU of 3v1h by Molmil](/molmil-images/mine/3v1h) | Structure of the H258Y mutant of Phosphatidylinositol-specific phospholipase C from Staphylococcus aureus | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, ACETATE ION | 著者 | Goldstein, R.I, Cheng, J, Stec, B, Roberts, M.F. | 登録日 | 2011-12-09 | 公開日 | 2012-04-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of the S. aureus PI-Specific Phospholipase C Reveals Modulation of Active Site Access by a Titratable PI-Cation Latched Loop Biochemistry, 51, 2012
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4I9J
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![BU of 4i9j by Molmil](/molmil-images/mine/4i9j) | Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC | 分子名称: | (4S,7R)-7-(heptanoyloxy)-4-hydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphahexadecan-1-aminium 4-oxide, 1-phosphatidylinositol phosphodiesterase, ACETATE ION | 著者 | Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F. | 登録日 | 2012-12-05 | 公開日 | 2013-04-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | The cation-pi box is a specific phosphatidylcholine membrane targeting motif. J.Biol.Chem., 288, 2013
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4I9T
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![BU of 4i9t by Molmil](/molmil-images/mine/4i9t) | Structure of the H258Y mutant of the phosphatidylinositol-specific phospholipase C from Staphylococcus aureus | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, SULFATE ION, ... | 著者 | Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F. | 登録日 | 2012-12-05 | 公開日 | 2013-04-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The cation-pi box is a specific phosphatidylcholine membrane targeting motif. J.Biol.Chem., 288, 2013
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2P3N
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![BU of 2p3n by Molmil](/molmil-images/mine/2p3n) | Thermotoga maritima IMPase TM1415 | 分子名称: | Inositol-1-monophosphatase, MAGNESIUM ION | 著者 | Stieglitz, K.A, Roberts, M.F, Li, W, Stec, B. | 登録日 | 2007-03-09 | 公開日 | 2007-04-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of the tetrameric inositol 1-phosphate phosphatase (TM1415) from the hyperthermophile, Thermotoga maritima. Febs J., 274, 2007
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2P3V
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![BU of 2p3v by Molmil](/molmil-images/mine/2p3v) | Thermotoga maritima IMPase TM1415 | 分子名称: | Inositol-1-monophosphatase, S,R MESO-TARTARIC ACID | 著者 | Stieglitz, K.A, Roberts, M.F, Li, W, Stec, B. | 登録日 | 2007-03-09 | 公開日 | 2007-04-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of the tetrameric inositol 1-phosphate phosphatase (TM1415) from the hyperthermophile, Thermotoga maritima. Febs J., 274, 2007
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4I8Y
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![BU of 4i8y by Molmil](/molmil-images/mine/4i8y) | Structure of the unliganded N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus | 分子名称: | 1-phosphatidylinositol phosphodiesterase, ACETATE ION, CHLORIDE ION | 著者 | Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F. | 登録日 | 2012-12-04 | 公開日 | 2013-04-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The cation-pi box is a specific phosphatidylcholine membrane targeting motif. J.Biol.Chem., 288, 2013
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4I90
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![BU of 4i90 by Molmil](/molmil-images/mine/4i90) | Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to choline | 分子名称: | 1-phosphatidylinositol phosphodiesterase, ACETATE ION, CHLORIDE ION, ... | 著者 | Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F. | 登録日 | 2012-12-04 | 公開日 | 2013-04-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The cation-pi box is a specific phosphatidylcholine membrane targeting motif. J.Biol.Chem., 288, 2013
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4I9M
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![BU of 4i9m by Molmil](/molmil-images/mine/4i9m) | Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from Staphylococcus aureus bound to HEPES | 分子名称: | 1-phosphatidylinositol phosphodiesterase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION | 著者 | Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F. | 登録日 | 2012-12-05 | 公開日 | 2013-04-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The cation-pi box is a specific phosphatidylcholine membrane targeting motif. J.Biol.Chem., 288, 2013
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7RYC
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![BU of 7ryc by Molmil](/molmil-images/mine/7ryc) | Oxytocin receptor (OTR) bound to oxytocin in complex with a heterotrimeric Gq protein | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Meyerowitz, J.G, Robertson, M.J, Skiniotis, G. | 登録日 | 2021-08-24 | 公開日 | 2022-03-09 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | The oxytocin signaling complex reveals a molecular switch for cation dependence. Nat.Struct.Mol.Biol., 29, 2022
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6W2X
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![BU of 6w2x by Molmil](/molmil-images/mine/6w2x) | CryoEM Structure of Inactive GABAB Heterodimer | 分子名称: | (1S)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Papasergi-Scott, M.M, Robertson, M.J, Skiniotis, G. | 登録日 | 2020-03-08 | 公開日 | 2020-07-01 | 最終更新日 | 2020-08-26 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structures of metabotropic GABABreceptor. Nature, 584, 2020
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6W2Y
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![BU of 6w2y by Molmil](/molmil-images/mine/6w2y) | CryoEM Structure of GABAB1b Homodimer | 分子名称: | (1S)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Papasergi-Scott, M.M, Robertson, M.J, Skiniotis, G. | 登録日 | 2020-03-08 | 公開日 | 2020-07-01 | 最終更新日 | 2020-08-26 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of metabotropic GABABreceptor. Nature, 584, 2020
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8GHV
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![BU of 8ghv by Molmil](/molmil-images/mine/8ghv) | Cannabinoid Receptor 1-G Protein Complex | 分子名称: | (5Z,8Z,11Z,13S,14Z)-N-[(2R)-1-hydroxypropan-2-yl]-13-methylicosa-5,8,11,14-tetraenamide, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Krishna Kumar, K, Robertson, M.J, Skiniotis, G, Kobilka, B.K. | 登録日 | 2023-03-12 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for activation of CB1 by an endocannabinoid analog. Nat Commun, 14, 2023
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7T2H
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![BU of 7t2h by Molmil](/molmil-images/mine/7t2h) | CryoEM structure of mu-opioid receptor - Gi protein complex bound to lofentanil (LFT) | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Seven, A.B, Qu, Q, Huang, W, Robertson, M.J, Kobilka, B.K, Skiniotis, G. | 登録日 | 2021-12-04 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Insights into distinct signaling profiles of the mu OR activated by diverse agonists. Nat.Chem.Biol., 2022
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