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PDB: 334 件
1TPW
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TRIOSEPHOSPHATE ISOMERASE DRINKS WATER TO KEEP HEALTHY
分子名称: PHOSPHOGLYCOLOHYDROXAMIC ACID, TRIOSEPHOSPHATE ISOMERASE
著者Zhang, Z, Sugio, S, Komives, E.A, Liu, K.D, Stock, A.M, Narayana, N, Xuong, Ng.H, Knowles, J.R, Petsko, G.A, Ringe, D.
登録日1994-11-07
公開日1995-04-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The role of water in the catalytic efficiency of triosephosphate isomerase.
Biochemistry, 38, 1999
2QB3
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Structural Studies Reveal the Inactivation of E. coli L-Aspartate Aminotransferase by (s)-4,5-dihydro-2-thiophenecarboxylic acid (SADTA) via Two Mechanisms (at pH 7.5)
分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, Aspartate aminotransferase, ...
著者Liu, D, Pozharski, E, Lepore, B, Fu, M, Silverman, R.B, Petsko, G.A, Ringe, D.
登録日2007-06-15
公開日2007-12-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms".
Biochemistry, 46, 2007
1ELF
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BU of 1elf by Molmil
NATURE OF THE INACTIVATION OF ELASTASE BY N-PEPTIDYL-O-AROYL HYDROXYLAMINE AS A FUNCTION OF PH
分子名称: (TERT-BUTYLOXYCARBONYL)-ALANYL-AMINO ETHYL-FORMAMIDE, CALCIUM ION, PORCINE PANCREATIC ELASTASE, ...
著者Ding, X, Rasmussen, B, Demuth, H.-U, Ringe, D, Steinmetz, A.C.U.
登録日1995-03-13
公開日1995-07-10
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Nature of the inactivation of elastase by N-peptidyl-O-aroyl hydroxylamine as a function of pH.
Biochemistry, 34, 1995
1ELC
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BU of 1elc by Molmil
Analogous inhibitors of elastase do not always bind analogously
分子名称: 6-ammonio-N-(trifluoroacetyl)-L-norleucyl-N-[4-(1-methylethyl)phenyl]-L-phenylalaninamide, CALCIUM ION, ELASTASE
著者Mattos, C, Rasmussen, B, Ding, X, Petsko, G.A, Ringe, D.
登録日1993-12-07
公開日1994-04-30
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Analogous inhibitors of elastase do not always bind analogously.
Nat.Struct.Biol., 1, 1994
2QA3
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Structural Studies Reveal the Inactivation of E. coli L-aspartate aminotransferase by (S)-4,5-amino-dihydro-2-thiophenecarboxylic acid (SADTA) via two mechanisms (at pH6.5)
分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, Aspartate aminotransferase, ...
著者Liu, D, Pozharski, E, Lepore, B, Fu, M, Silverman, R.B, Petsko, G.A, Ringe, D.
登録日2007-06-14
公開日2007-12-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms".
Biochemistry, 46, 2007
1ESA
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BU of 1esa by Molmil
DIRECT STRUCTURE OBSERVATION OF AN ACYL-ENZYME INTERMEDIATE IN THE HYDROLYSIS OF AN ESTER SUBSTRATE BY ELASTASE
分子名称: CALCIUM ION, PORCINE PANCREATIC ELASTASE, SULFATE ION
著者Ding, X, Rasmussen, B, Petsko, G.A, Ringe, D.
登録日1994-02-04
公開日1994-04-30
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Direct structural observation of an acyl-enzyme intermediate in the hydrolysis of an ester substrate by elastase.
Biochemistry, 33, 1994
1OT5
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The 2.4 Angstrom Crystal Structure of Kex2 in complex with a peptidyl-boronic acid inhibitor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ac-Ala-Lys-boroArg N-acetylated boronic acid peptide inhibitor, ...
著者Holyoak, T, Wilson, M.A, Fenn, T.D, Kettner, C.A, Petsko, G.A, Fuller, R.S, Ringe, D.
登録日2003-03-21
公開日2003-06-17
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献2.4 A Resolution Crystal Structure of the Prototypical Hormone-Processing Protease Kex2 in Complex with an Ala-Lys-Arg Boronic Acid Inhibitor
Biochemistry, 42, 2003
1AZ2
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CITRATE BOUND, C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE
分子名称: ALDOSE REDUCTASE, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Harrison, D.H, Bohren, K.M, Ringe, D, Petsko, G.A, Gabbay, K.H.
登録日1997-11-24
公開日1998-03-18
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.
Biochemistry, 36, 1997
4PSY
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BU of 4psy by Molmil
100K crystal structure of Escherichia coli dihydrofolate reductase
分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
著者Wilson, M.A, Wan, Q, Bennet, B.C, Dealwis, C, Ringe, D, Petsko, G.A.
登録日2014-03-08
公開日2014-05-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (0.85 Å)
主引用文献Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography.
Proc.Natl.Acad.Sci.USA, 22, 2014
1ELA
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BU of 1ela by Molmil
Analogous inhibitors of elastase do not always bind analogously
分子名称: 6-ammonio-N-(trifluoroacetyl)-L-norleucyl-N-[4-(1-methylethyl)phenyl]-L-prolinamide, ACETIC ACID, CALCIUM ION, ...
著者Mattos, C, Rasmussen, B, Ding, X, Petsko, G.A, Ringe, D.
登録日1993-12-07
公開日1994-04-30
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Analogous inhibitors of elastase do not always bind analogously.
Nat.Struct.Biol., 1, 1994
1ELG
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BU of 1elg by Molmil
NATURE OF THE INACTIVATION OF ELASTASE BY N-PEPTIDYL-O-AROYL HYDROXYLAMINE AS A FUNCTION OF PH
分子名称: (TERT-BUTYLOXYCARBONYL)-ALANYL-ALANYL-AMINE, CALCIUM ION, PORCINE PANCREATIC ELASTASE
著者Ding, X, Rasmussen, B, Demuth, H.-U, Ringe, D, Steinmetz, A.C.U.
登録日1995-03-13
公開日1995-07-10
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Nature of the inactivation of elastase by N-peptidyl-O-aroyl hydroxylamine as a function of pH.
Biochemistry, 34, 1995
2QBT
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Structural Studies Reveal The Inactivation of E. coli L-aspartate aminotransferase by (S)-4,5-amino-dihydro-2-thiophenecarboxylic acid (SADTA) via Two Mechanisms (at pH 8.0)
分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, Aspartate aminotransferase, ...
著者Liu, D, Pozharski, E, Lepore, B, Fu, M, Silverman, R.B, Petsko, G.A, Ringe, D.
登録日2007-06-18
公開日2007-09-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Inactivation of Escherichia coli l-Aspartate Aminotransferase by (S)-4-Amino-4,5-dihydro-2-thiophenecarboxylic Acid Reveals "A Tale of Two Mechanisms".
Biochemistry, 46, 2007
1ELB
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BU of 1elb by Molmil
Analogous inhibitors of elastase do not always bind analogously
分子名称: 6-ammonio-N-(trifluoroacetyl)-L-norleucyl-N-[4-(1-methylethyl)phenyl]-L-leucinamide, CALCIUM ION, ELASTASE, ...
著者Mattos, C, Rasmussen, B, Ding, X, Petsko, G.A, Ringe, D.
登録日1993-12-07
公開日1994-06-22
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Analogous inhibitors of elastase do not always bind analogously.
Nat.Struct.Biol., 1, 1994
1SFT
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BU of 1sft by Molmil
ALANINE RACEMASE
分子名称: ACETATE ION, ALANINE RACEMASE, PYRIDOXAL-5'-PHOSPHATE
著者Shaw, J.P, Petsko, G.A, Ringe, D.
登録日1996-09-20
公開日1997-02-12
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Determination of the structure of alanine racemase from Bacillus stearothermophilus at 1.9-A resolution.
Biochemistry, 36, 1997
2QQB
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Crystal Structure of DtxR(M10A C102D) Complexed with Nickel(II)
分子名称: Diphtheria toxin repressor, NICKEL (II) ION, PHOSPHATE ION
著者D'Aquino, J.A, Lattimer, J.R, Denninger, A, D'Aquino, K.E, Ringe, D.
登録日2007-07-26
公開日2007-10-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Role of the N-Terminal Helix in the Metal Ion-Induced Activation of the Diphtheria Toxin Repressor DtxR.
Biochemistry, 46, 2007
1EEP
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BU of 1eep by Molmil
2.4 A RESOLUTION CRYSTAL STRUCTURE OF BORRELIA BURGDORFERI INOSINE 5'-MONPHOSPHATE DEHYDROGENASE IN COMPLEX WITH A SULFATE ION
分子名称: INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE, SULFATE ION
著者McMillan, F.M, Cahoon, M, White, A, Hedstrom, L, Petsko, G.A, Ringe, D.
登録日2000-02-01
公開日2000-03-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6.
Biochemistry, 39, 2000
1DQR
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CRYSTAL STRUCTURE OF RABBIT PHOSPHOGLUCOSE ISOMERASE, A GLYCOLYTIC ENZYME THAT MOONLIGHTS AS NEUROLEUKIN, AUTOCRINE MOTILITY FACTOR, AND DIFFERENTIATION MEDIATOR
分子名称: 6-PHOSPHOGLUCONIC ACID, PHOSPHOGLUCOSE ISOMERASE
著者Bahnson, B.J, Jeffery, C.J, Ringe, D, Petsko, G.A.
登録日2000-01-05
公開日2000-02-09
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator.
Biochemistry, 39, 2000
1FT7
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AAP COMPLEXED WITH L-LEUCINEPHOSPHONIC ACID
分子名称: BACTERIAL LEUCYL AMINOPEPTIDASE, LEUCINE PHOSPHONIC ACID, POTASSIUM ION, ...
著者Stamper, C, Bennett, B, Holz, R, Petsko, G, Ringe, D.
登録日2000-09-11
公開日2000-10-04
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Inhibition of the aminopeptidase from Aeromonas proteolytica by L-leucinephosphonic acid. Spectroscopic and crystallographic characterization of the transition state of peptide hydrolysis.
Biochemistry, 40, 2001
2QQA
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Crystal Structure of DtxR(E9A C102D) Complexed with Nickel(II)
分子名称: Diphtheria toxin repressor, NICKEL (II) ION, PHOSPHATE ION
著者D'Aquino, J.A, Lattimer, J.R, Denninger, A, D'Aquino, K.E, Ringe, D.
登録日2007-07-26
公開日2007-10-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Role of the N-Terminal Helix in the Metal Ion-Induced Activation of the Diphtheria Toxin Repressor DtxR.
Biochemistry, 46, 2007
1F7Z
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RAT TRYPSINOGEN K15A COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR
分子名称: CALCIUM ION, PANCREATIC TRYPSIN INHIBITOR, SULFATE ION, ...
著者Pasternak, A, White, A, Jeffery, C.J, Medina, N, Cahoon, M, Ringe, D, Hedstrom, L.
登録日2000-06-28
公開日2001-07-04
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity.
Protein Sci., 10, 2001
1FY8
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CRYSTAL STRUCTURE OF THE DELTAILE16VAL17 RAT ANIONIC TRYPSINOGEN-BPTI COMPLEX
分子名称: CALCIUM ION, PANCREATIC TRYPSIN INHIBITOR, SULFATE ION, ...
著者Pasternak, A, White, A, Jeffery, C.J, Ringe, D, Hedstrom, L.
登録日2000-09-28
公開日2000-11-08
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity.
Protein Sci., 10, 2001
1F5T
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DIPHTHERIA TOX REPRESSOR (C102D MUTANT) COMPLEXED WITH NICKEL AND DTXR CONSENSUS BINDING SEQUENCE
分子名称: 43MER DNA CONTAINING DXTR CONSENSUS BINDING SEQUENCE, DIPHTHERIA TOXIN REPRESSOR, NICKEL (II) ION
著者Chen, S, White, A, Love, J, Murphy, J.R, Ringe, D.
登録日2000-06-15
公開日2000-09-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Methyl groups of thymine bases are important for nucleic acid recognition by DtxR.
Biochemistry, 39, 2000
1DZ9
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Putative oxo complex of P450cam from Pseudomonas putida
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, CYTOCHROME P450-CAM, ...
著者Schlichting, I, Berendzen, J, Chu, K, Stock, A.M, Maves, S.A, Benson, D.E, Sweet, R.M, Ringe, D, Petsko, G.A, Sligar, S.G.
登録日2000-02-18
公開日2000-03-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Catalytic Pathway of Cytochrome P450Cam at Atomic Resolution
Science, 287, 2000
1DZ4
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ferric p450cam from pseudomonas putida
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, CYTOCHROME P450-CAM, ...
著者Schlichting, I, Berendzen, J, Chu, K, Stock, A.M, Maves, S.A, Benson, D.E, Sweet, R.M, Ringe, D, Petsko, G.A, Sligar, S.G.
登録日2000-02-16
公開日2000-07-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The Catalytic Pathway of Cytochrome P450Cam at Atomic Resolution
Science, 287, 2000
1DZ6
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ferrous p450cam from pseudomonas putida
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, CYTOCHROME P450-CAM, ...
著者Schlichting, I, Berendzen, J, Chu, K, Stock, A.M, Maves, S.A, Benson, D.E, Sweet, R.M, Ringe, D, Petsko, G.A, Sligar, S.G.
登録日2000-02-18
公開日2000-03-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Catalytic Pathway of Cytochrome P450Cam at Atomic Resolution
Science, 287, 2000

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