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PDB: 12 件
5G1X
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BU of 5g1x by Molmil
Crystal structure of Aurora-A kinase in complex with N-Myc
分子名称: ADENOSINE-5'-DIPHOSPHATE, AURORA KINASE A, MAGNESIUM ION, ...
著者Richards, M.W, Burgess, S.G, Bayliss, R.
登録日2016-03-31
公開日2016-11-16
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Structural Basis of N-Myc Binding by Aurora-A and its Destabilization by Kinase Inhibitors
Proc.Natl.Acad.Sci.USA, 113, 2016
6SGK
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BU of 6sgk by Molmil
Nek2 kinase bound to inhibitor 102
分子名称: 2-phenylazanyl-9~{H}-purine-6-carbonitrile, Serine/threonine-protein kinase Nek2
著者Richards, M.W, Mas-Droux, C.P, Bayliss, R.
登録日2019-08-05
公開日2020-06-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase.
Rsc Med Chem, 11, 2020
6SGD
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BU of 6sgd by Molmil
Nek2 kinase covalently bound to 2-arylamino-6-ethynylpurine inhibitor 24
分子名称: 4-[(6-ethenyl-7~{H}-purin-2-yl)amino]benzenesulfonamide, CHLORIDE ION, SODIUM ION, ...
著者Richards, M.W, Mas-Droux, C.P, Bayliss, R.
登録日2019-08-04
公開日2020-06-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase.
Rsc Med Chem, 11, 2020
6SGI
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BU of 6sgi by Molmil
Nek2 kinase bound to inhibitor 96
分子名称: 4-[(6-ethyl-7~{H}-purin-2-yl)amino]benzenesulfonamide, CHLORIDE ION, Serine/threonine-protein kinase Nek2
著者Richards, M.W, Mas-Droux, C.P, Bayliss, R.
登録日2019-08-05
公開日2020-06-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase.
Rsc Med Chem, 11, 2020
6SGH
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BU of 6sgh by Molmil
Nek2 kinase covalently bound to 2-arylamino-6-ethynylpurine inhibitor 66
分子名称: 2-[4-[(6-ethenyl-9~{H}-purin-2-yl)amino]phenyl]ethanamide, Serine/threonine-protein kinase Nek2
著者Richards, M.W, Mas-Droux, C.P, Bayliss, R.
登録日2019-08-04
公開日2020-06-17
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase.
Rsc Med Chem, 11, 2020
2WQM
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BU of 2wqm by Molmil
Structure of apo human Nek7
分子名称: NICKEL (II) ION, SERINE/THREONINE-PROTEIN KINASE NEK7, SULFATE ION
著者Richards, M.W, Bayliss, R.
登録日2009-08-24
公開日2009-12-08
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献An Auto-Inhibitory Tyrosine Motif in the Cell-Cycle Regulated Nek7 Kinase is Released Through Binding of Nek9
Mol.Cell, 36, 2009
4CGC
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BU of 4cgc by Molmil
Crystal structure of the trimerization domain of human EML4
分子名称: ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 4
著者Richards, M.W, Bayliss, R.
登録日2013-11-21
公開日2014-12-10
最終更新日2015-04-29
実験手法X-RAY DIFFRACTION (2.901 Å)
主引用文献Microtubule Association of Eml Proteins and the Eml4-Alk Variant 3 Oncoprotein Require an N-Terminal Trimerization Domain.
Biochem.J., 467, 2015
4CGB
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BU of 4cgb by Molmil
Crystal structure of the trimerization domain of EML2
分子名称: ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2, GLYCEROL, POTASSIUM ION
著者Richards, M.W, Bayliss, R.
登録日2013-11-21
公開日2014-12-10
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.154 Å)
主引用文献Microtubule Association of Eml Proteins and the Eml4-Alk Variant 3 Oncoprotein Require an N-Terminal Trimerization Domain.
Biochem.J., 467, 2015
4CI8
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BU of 4ci8 by Molmil
Crystal structure of the tandem atypical beta-propeller domain of EML1
分子名称: ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 1, SULFATE ION
著者Richards, M.W, Bayliss, R.
登録日2013-12-06
公開日2014-04-16
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of Eml1 Reveals the Basis for Hsp90 Dependence of Oncogenic Eml4-Alk by Disruption of an Atypical Beta-Propeller Domain.
Proc.Natl.Acad.Sci.USA, 111, 2014
2WQN
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BU of 2wqn by Molmil
Structure of ADP-bound human Nek7
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, NICKEL (II) ION, ...
著者Richards, M.W, Bayliss, R.
登録日2009-08-24
公開日2009-12-08
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献An Autoinhibitory Tyrosine Motif in the Cell-Cycle- Regulated Nek7 Kinase is Released Through Binding of Nek9.
Mol.Cell, 36, 2009
2WT8
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BU of 2wt8 by Molmil
Structure of the N-terminal BRCT domain of human microcephalin (Mcph1)
分子名称: ACETATE ION, CHLORIDE ION, MICROCEPHALIN
著者Richards, M.W, Roe, S.M, Bayliss, R.
登録日2009-09-14
公開日2009-12-01
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A Pocket on the Surface of the N-Terminal Brct Domain of Mcph1 is Required to Prevent Abnormal Chromosome Condensation.
J.Mol.Biol., 395, 2010
5ORL
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BU of 5orl by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
分子名称: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, CHLORIDE ION, ...
著者McIntyre, P.J, Collins, P.M, Vrzal, L, Birchall, K, Arnold, L.H, Mpamhanga, C, Coombs, P.J, Burgess, S.G, Richards, M.W, Winter, A, Veverka, V, von Delft, F, Merritt, A, Bayliss, R.
登録日2017-08-16
公開日2017-11-01
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017

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件を2024-10-30に公開中

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