3MNR
 
 | | Crystal Structure of Benzamide SNX-1321 bound to Hsp90 | | Descriptor: | 2-[(3,4,5-trimethoxyphenyl)amino]-4-(2,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide, Heat shock protein HSP 90-alpha | | Authors: | Veal, J.M, Fadden, P, Huang, K.H, Rice, J, Hall, S.E, Haytstead, T.A. | | Deposit date: | 2010-04-22 | | Release date: | 2010-08-11 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90.
Chem.Biol., 17, 2010
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1BPS
 | | MINOR CONFORMER OF A BENZO[A]PYRENE DIOL EPOXIDE ADDUCT OF DA IN DUPLEX DNA | | Descriptor: | 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, DNA (5'-D(*CP*TP*CP*GP*GP*GP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*(BAP)AP*CP*GP*AP*G)-3') | | Authors: | Schwartz, J.S, Rice, J.S, Luxon, B.A, Sayer, J.M, Xie, G, Yeh, H.J.C, Liu, X, Jerina, D.M, Gorenstein, D.G. | | Deposit date: | 1998-08-06 | | Release date: | 1998-08-19 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the minor conformer of a DNA duplex containing a dG mismatch opposite a benzo[a]pyrene diol epoxide/dA adduct: glycosidic rotation from syn to anti at the modified deoxyadenosine.
Biochemistry, 36, 1997
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1YXU
 | | Crystal Structure of Kinase Pim1 in Complex with AMP | | Descriptor: | ADENOSINE MONOPHOSPHATE, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase Pim-1 | | Authors: | Kumar, A, Mandiyan, V, Suzuki, Y, Zhang, C, Rice, J, Tsai, J, Artis, D.R, Ibrahim, P, Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma.
J.Mol.Biol., 348, 2005
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1YXT
 | | Crystal Structure of Kinase Pim1 in complex with AMPPNP | | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Proto-oncogene serine/threonine-protein kinase Pim-1 | | Authors: | Kumar, A, Mandiyan, V, Suzuki, Y, Zhang, C, Rice, J, Tsai, J, Artis, D.R, Ibrahim, P, Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
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1YWV
 | | Crystal Structures of Proto-Oncogene Kinase Pim1: a Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma | | Descriptor: | IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase Pim-1 | | Authors: | Kumar, A, Mandiyan, V, Suzuki, Y, Zhang, C, Rice, J, Tsai, J, Artis, D.R, Ibrahim, P, Bremer, R. | | Deposit date: | 2005-02-18 | | Release date: | 2005-04-26 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
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1YXV
 | | Crystal Structure of Kinase Pim1 in complex with 3,4-Dihydroxy-1-methylquinolin-2(1H)-one | | Descriptor: | 3,4-DIHYDROXY-1-METHYLQUINOLIN-2(1H)-ONE, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase Pim-1 | | Authors: | Kumar, A, Mandiyan, V, Suzuki, Y, Zhang, C, Rice, J, Tsai, J, Artis, D.R, Ibrahim, P, Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma.
J.Mol.Biol., 348, 2005
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1YXS
 | | Crystal Structure of Kinase Pim1 with P123M mutation | | Descriptor: | IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase Pim-1 | | Authors: | Kumar, A, Mandiyan, V, Suzuki, Y, Zhang, C, Rice, J, Tsai, J, Artis, D.R, Ibrahim, P, Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
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1YXX
 | | Crystal Structure of Kinase Pim1 in complex with (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE | | Descriptor: | (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase Pim-1 | | Authors: | Kumar, A, Mandiyan, V, Suzuki, Y, Zhang, C, Rice, J, Tsai, J, Artis, D.R, Ibrahim, P, Bremer, R. | | Deposit date: | 2005-02-22 | | Release date: | 2005-04-26 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
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1AC3
 | | SOLUTION STRUCTURE OF AN RNA-DNA HYBRID DUPLEX CONTAINING A 3'-THIOFORMACETAL LINKER AND AN RNA A-TRACT, NMR, 8 STRUCTURES | | Descriptor: | ANTISENSE HYBRID DUPLEX, DNA (5'-D(*(TCP)P*TP*GP*CP*GP*C)-3') | | Authors: | Cross, C.W, Rice, J.S, Gao, X. | | Deposit date: | 1997-02-11 | | Release date: | 1997-06-16 | | Last modified: | 2024-04-10 | | Method: | SOLUTION NMR | | Cite: | Solution structure of an RNA x DNA hybrid duplex containing a 3'-thioformacetal linker and an RNA A-tract.
Biochemistry, 36, 1997
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1N8C
 | | Solution Structure of a Cis-Opened (10R)-N6-Deoxyadenosine Adduct of (9S,10R)-(9,10)-Epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a DNA Duplex | | Descriptor: | (9S,10R)-9-HYDROXY-7,8,9,10-TETRAHYDROBENZO[A]PYRENE, 5'-D(*CP*CP*TP*CP*GP*TP*GP*AP*CP*CP*G)-3', 5'-D(*CP*GP*GP*TP*CP*AP*CP*GP*AP*GP*G)-3' | | Authors: | Volk, D.E, Thiviyanathan, V, Rice, J.S, Luxon, B.A, Shah, J.H, Yagi, H, Sayer, J.M, Yeh, H.J.C, Jerina, D.M, Gorenstein, D.G. | | Deposit date: | 2002-11-20 | | Release date: | 2003-02-14 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of a Cis-Opened (10R)-N6-Deoxyadenosine Adduct of (9S,10R)-(9,10)-Epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a DNA Duplex
Biochemistry, 42, 2003
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1FYY
 | | HPRT GENE MUTATION HOTSPOT WITH A BPDE2(10R) ADDUCT | | Descriptor: | 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, 5'-D(*TP*GP*CP*CP*CP*TP*TP*GP*AP*CP*TP*A)-3', HPRT DNA WITH BENZO[A]PYRENE-ADDUCTED DA7 | | Authors: | Volk, D.E, Rice, J.S, Luxon, B.A, Yeh, H.J.C, Liang, C, Xie, G, Sayer, J.M, Jerina, D.M, Gorenstein, D.G. | | Deposit date: | 2000-10-03 | | Release date: | 2000-12-06 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR evidence for syn-anti interconversion of a trans opened (10R)-dA adduct of benzo[a]pyrene (7S,8R)-diol (9R,10S)-epoxide in a DNA duplex.
Biochemistry, 39, 2000
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3C3H
 | | alpha/beta-Peptide helix bundles: A GCN4-pLI analogue with an (alpha-alpha-beta) backbone and cyclic beta residues | | Descriptor: | alpha/beta-peptide based on the GCN4-pLI side chain sequence, with an (alpha-alpha-beta) backbone and cyclic beta-residues at positions 1, 4, ... | | Authors: | Horne, W.S, Price, J.L, Gellman, S.H. | | Deposit date: | 2008-01-28 | | Release date: | 2008-06-17 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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6U47
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6V4Y
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6V50
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6V58
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6V5G
 | | Coiled-coil Trimer with Ala:Leu:Lys Triad | | Descriptor: | Coiled-coil Trimer with Ala:Leu:Lys Triad, PENTAETHYLENE GLYCOL | | Authors: | Smith, M.S, Stern, K.L, Billings, W.M, Price, J.L. | | Deposit date: | 2019-12-04 | | Release date: | 2020-04-29 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle.
Biochemistry, 59, 2020
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8U7T
 | | Substrate-bound Cdc48, Class 1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 48, MAGNESIUM ION, ... | | Authors: | Cooney, I, Schubert, H.L, Cedeno, K, Lin, H.J.L, Fisher, O.N, Price, J.C, Hill, C.P, Shen, P.S. | | Deposit date: | 2023-09-15 | | Release date: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway.
Nat Commun, 15, 2024
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8UB4
 | | Cdc48-Shp1 unfolding native substrate, consensus structure | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 48, MAGNESIUM ION, ... | | Authors: | Cooney, I, Schubert, H.L, Cedeno, K, Carson, R, Fisher, O.N, Price, J.C, Hill, C.P, Shen, P.S. | | Deposit date: | 2023-09-22 | | Release date: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway.
Nat Commun, 15, 2024
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8U8I
 | | Cdc48-Shp1 unfolding native substrate, Class 4 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 48, MAGNESIUM ION, ... | | Authors: | Cooney, I, Schubert, H.L, Cedeno, K, Carson, R, Fisher, O.N, Price, J.C, Hill, C.P, Shen, P.S. | | Deposit date: | 2023-09-18 | | Release date: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway.
Nat Commun, 15, 2024
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8U9Z
 | | Cdc48-Shp1 unfolding native substrate, Class 7 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 48, MAGNESIUM ION, ... | | Authors: | Cooney, I, Schubert, H.L, Cedeno, K, Carson, R, Fisher, O.N, Price, J.C, Hill, C.P, Shen, P.S. | | Deposit date: | 2023-09-20 | | Release date: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway.
Nat Commun, 15, 2024
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8UAA
 | | Cdc48-Shp1 unfolding native substrate, Class 3 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 48, MAGNESIUM ION, ... | | Authors: | Cooney, I, Schubert, H.L, Cedeno, K, Carson, R, Fisher, O.N, Price, J.C, Hill, C.P, Shen, P.S. | | Deposit date: | 2023-09-20 | | Release date: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway.
Nat Commun, 15, 2024
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8U9Q
 | | Cdc48-Shp1 unfolding native substrate, Class 6 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 48, MAGNESIUM ION, ... | | Authors: | Cooney, I, Schubert, H.L, Cedeno, K, Carson, R, Fisher, O.N, Price, J.C, Hill, C.P, Shen, P.S. | | Deposit date: | 2023-09-19 | | Release date: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway.
Nat Commun, 15, 2024
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8U9P
 | | Cdc48-Shp1 unfolding native substrate, Class 2 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 48, MAGNESIUM ION, ... | | Authors: | Cooney, I, Schubert, H.L, Cedeno, K, Carson, R, Fisher, O.N, Price, J.C, Hill, C.P, Shen, P.S. | | Deposit date: | 2023-09-19 | | Release date: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway.
Nat Commun, 15, 2024
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8UA1
 | | Cdc48-Shp1 unfolding native substrate, Class 9 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 48, MAGNESIUM ION, ... | | Authors: | Cooney, I, Schubert, H.L, Cedeno, K, Carson, R, Fisher, O.N, Price, J.C, Hill, C.P, Shen, P.S. | | Deposit date: | 2023-09-20 | | Release date: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway.
Nat Commun, 15, 2024
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