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PDB: 776 件

2VEK
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Structure-based enzyme engineering efforts with an inactive monomeric TIM variant: the importance of a single point mutation for generating an active site with suitable binding properties
分子名称: 3-(BUTYLSULPHONYL)-PROPANOIC ACID, CITRIC ACID, TERTIARY-BUTYL ALCOHOL, ...
著者Alahuhta, M, Salin, M, Casteleijn, M.G, Kemmer, C, El-Sayed, I, Augustyns, K, Neubauer, P, Wierenga, R.K.
登録日2007-10-24
公開日2008-02-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure-Based Protein Engineering Efforts with a Monomeric Tim Variant: The Importance of a Single Point Mutation for Generating an Active Site with Suitable Binding Properties.
Protein Eng.Des.Sel., 21, 2008
2VEN
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BU of 2ven by Molmil
Structure-based enzyme engineering efforts with an inactive monomeric TIM variant: the importance of a single point mutation for generating an active site with suitable binding properties
分子名称: CITRIC ACID, GLYCOSOMAL TRIOSEPHOSPHATE ISOMERASE
著者Alahuhta, M, Salin, M, Casteleijn, M.G, Kemmer, C, El-Sayed, I, Augustyns, K, Neubauer, P, Wierenga, R.K.
登録日2007-10-25
公開日2008-02-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure-Based Protein Engineering Efforts with a Monomeric Tim Variant: The Importance of a Single Point Mutation for Generating an Active Site with Suitable Binding Properties.
Protein Eng.Des.Sel., 21, 2008
2HIS
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BU of 2his by Molmil
CELLULOMONAS FIMI XYLANASE/CELLULASE DOUBLE MUTANT E127A/H205N WITH COVALENT CELLOBIOSE
分子名称: CELLULOMONAS FIMI FAMILY 10 BETA-1,4-GLYCANASE, beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Notenboom, V, Birsan, C, Nitz, M, Rose, D.R, Warren, R.A.J, Wither, S.G.
登録日1998-02-23
公開日1998-10-14
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Insights into transition state stabilization of the beta-1,4-glycosidase Cex by covalent intermediate accumulation in active site mutants.
Nat.Struct.Biol., 5, 1998
4KUL
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BU of 4kul by Molmil
Crystal structure of N-terminal acetylated yeast Sir3 BAH domain V83P mutant
分子名称: Regulatory protein SIR3
著者Yang, D, Fang, Q, Wang, M, Ren, R, Wang, H, He, M, Sun, Y, Yang, N, Xu, R.M.
登録日2013-05-22
公開日2013-08-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献N alpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain.
Nat.Struct.Mol.Biol., 20, 2013
3MV8
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BU of 3mv8 by Molmil
Crystal Structure of the TK3-Gln55His TCR in complex with HLA-B*3501/HPVG
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-35 alpha chain, ...
著者Gras, S, Chen, Z, Miles, J.J, Liu, Y.C, Bell, M.J, Sullivan, L.C, Kjer-Nielsen, L, Brennan, R.M, Burrows, J.M, Neller, M.A, Khanna, R, Purcell, A.W, Brooks, A.G, McCluskey, J, Rossjohn, J, Burrows, S.R.
登録日2010-05-03
公開日2010-06-09
最終更新日2011-07-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Allelic polymorphism in the T cell receptor and its impact on immune responses
J.Exp.Med., 207, 2010
3MV7
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BU of 3mv7 by Molmil
Crystal Structure of the TK3 TCR in complex with HLA-B*3501/HPVG
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-35 alpha chain, ...
著者Gras, S, Chen, Z, Miles, J.J, Liu, Y.C, Bell, M.J, Sullivan, L.C, Kjer-Nielsen, L, Brennan, R.M, Burrows, J.M, Neller, M.A, Khanna, R, Purcell, A.W, Brooks, A.G, McCluskey, J, Rossjohn, J, Burrows, S.R.
登録日2010-05-03
公開日2010-06-09
最終更新日2011-07-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Allelic polymorphism in the T cell receptor and its impact on immune responses
J.Exp.Med., 207, 2010
7ZSC
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BU of 7zsc by Molmil
Crystal structure of the heterodimeric human C-P4H-II with truncated alpha subunit (C-P4H-II delta281)
分子名称: Prolyl 4-hydroxylase subunit alpha-2, Protein disulfide-isomerase, SULFATE ION
著者Lebedev, A, Koski, M.K, Wierenga, R.K, Murthy, A.V, Sulu, R.
登録日2022-05-06
公開日2022-11-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.85 Å)
主引用文献Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H alpha 2 beta 2 tetramer.
J.Biol.Chem., 298, 2022
4KUD
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BU of 4kud by Molmil
Crystal structure of N-terminal acetylated Sir3 BAH domain D205N mutant in complex with yeast nucleosome core particle
分子名称: Histone H2A.2, Histone H2B.1, Histone H3, ...
著者Yang, D, Fang, Q, Wang, M, Ren, R, Wang, H, He, M, Sun, Y, Yang, N, Xu, R.M.
登録日2013-05-22
公開日2013-08-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.203 Å)
主引用文献N alpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain.
Nat.Struct.Mol.Biol., 20, 2013
3MV9
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BU of 3mv9 by Molmil
Crystal Structure of the TK3-Gln55Ala TCR in complex with HLA-B*3501/HPVG
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-35 alpha chain, ...
著者Gras, S, Chen, Z, Miles, J.J, Liu, Y.C, Bell, M.J, Sullivan, L.C, Kjer-Nielsen, L, Brennan, R.M, Burrows, J.M, Neller, M.A, Khanna, R, Purcell, A.W, Brooks, A.G, McCluskey, J, Rossjohn, J, Burrows, S.R.
登録日2010-05-03
公開日2010-06-09
最終更新日2011-07-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Allelic polymorphism in the T cell receptor and its impact on immune responses
J.Exp.Med., 207, 2010
4KUI
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BU of 4kui by Molmil
Crystal structure of N-terminal acetylated yeast Sir3 BAH domain
分子名称: ACETIC ACID, ISOPROPYL ALCOHOL, Regulatory protein SIR3
著者Yang, D, Fang, Q, Wang, M, Ren, R, Wang, H, He, M, Sun, Y, Yang, N, Xu, R.M.
登録日2013-05-22
公開日2013-08-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献N alpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain.
Nat.Struct.Mol.Biol., 20, 2013
2VCY
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BU of 2vcy by Molmil
Crystal Structure of 2-Enoyl Thioester Reductase of Human FAS II
分子名称: SULFATE ION, TRANS-2-ENOYL-COA REDUCTASE
著者Haapalainen, A.M, Pudas, R, Smart, O.S, Wierenga, R.K.
登録日2007-09-28
公開日2008-06-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Structural Enzymological Studies of 2-Enoyl Thioester Reductase of the Human Mitochondrial Fas II Pathway: New Insights Into its Substrate Recognition Properties.
J.Mol.Biol., 379, 2008
6WEG
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BU of 6weg by Molmil
Structure of Ft (MglA-SspA)-ppGpp-PigR peptide complex
分子名称: GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION, MglA, ...
著者Schumacher, M.A, Brennan, R.
登録日2020-04-02
公開日2020-11-11
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
5BYV
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BU of 5byv by Molmil
Crystal structure of MSM-13, a putative T1-like thiolase from Mycobacterium smegmatis
分子名称: Beta-ketothiolase
著者Janardan, N, Harijan, R.K, Keima, T.R, Wierenga, R, Murthy, M.R.N.
登録日2015-06-11
公開日2016-05-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.162 Å)
主引用文献Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatis
Acta Crystallogr.,Sect.D, 71, 2015
7TEC
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BU of 7tec by Molmil
Structure of the Listeria monocytogenes GlnR-DNA complex to 3.45 Angstrom
分子名称: DNA (5'-D(*CP*GP*TP*GP*TP*CP*AP*GP*AP*TP*AP*AP*TP*CP*TP*GP*AP*CP*AP*CP*G)-3'), HTH-type transcriptional regulator GlnR
著者Schumacher, M.A, Brennan, R.G.
登録日2022-01-04
公開日2022-06-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
Nat Commun, 13, 2022
2HQ5
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BU of 2hq5 by Molmil
Crystal structure of multidrug binding protein QacR from Staphylococcus aureus cocrystallized with compound DB359
分子名称: HTH-type transcriptional regulator qacR, SULFATE ION
著者Brooks, B.E, Brennan, R.G.
登録日2006-07-18
公開日2007-07-17
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Multidrug-Binding Transcription Factor QacR Binds the Bivalent Aromatic Diamidines DB75 and DB359 in Multiple Positions
J.Am.Chem.Soc., 129, 2007
5BZ4
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BU of 5bz4 by Molmil
Crystal structure of a T1-like thiolase (CoA-complex) from Mycobacterium smegmatis
分子名称: Beta-ketothiolase, COENZYME A
著者Janardan, N, Harijan, R.K, Kiema, T.R, Wierenga, R.K, Murthy, M.R.N.
登録日2015-06-11
公開日2016-05-18
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatis
Acta Crystallogr.,Sect.D, 71, 2015
3UDB
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BU of 3udb by Molmil
Crystal structure of SnRK2.6
分子名称: CHLORIDE ION, Serine/threonine-protein kinase SRK2E
著者Xie, T, Ren, R, Pang, Y, Yan, C.
登録日2011-10-27
公開日2011-11-16
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.567 Å)
主引用文献Molecular mechanism for the inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by the protein phosphatase ABI1
to be published
1J5E
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BU of 1j5e by Molmil
Structure of the Thermus thermophilus 30S Ribosomal Subunit
分子名称: 16S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ...
著者Wimberly, B.T, Brodersen, D.E, Clemons Jr, W.M, Morgan-Warren, R, Carter, A.P, Vonrhein, C, Hartsch, T, Ramakrishnan, V.
登録日2002-04-08
公開日2002-04-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Structure of the 30S ribosomal subunit.
Nature, 407, 2000
2V5L
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BU of 2v5l by Molmil
Structures of the Open and Closed State of Trypanosomal Triosephosphate Isomerase: as Observed in a New Crystal Form: Implications for the Reaction Mechanism
分子名称: SULFATE ION, TRIOSEPHOSPHATE ISOMERASE
著者Noble, M.E.M, Zeelen, J.P, Wierenga, R.K.
登録日2007-07-06
公開日2007-07-31
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of the Open and Closed State of Trypanosomal Triosephosphate Isomerase: As Observed in a New Crystal Form: Implications for the Reaction Mechanism
Proteins: Struct.,Funct., Genet., 16, 1993
6WA0
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BU of 6wa0 by Molmil
De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release
分子名称: De novo designed receptor transmembrane domain proMP C3.1
著者Call, M.J, Call, M.E, Chandler, N.J, Nguyen, J.V, Trenker, R.
登録日2020-03-24
公開日2021-03-31
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.484 Å)
主引用文献De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release
To Be Published
6W9Y
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BU of 6w9y by Molmil
De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release
分子名称: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, De novo designed receptor transmembrane domain proMP 1.2
著者Call, M.J, Call, M.E, Chandler, N.J, Nguyen, J.V, Trenker, R.
登録日2020-03-24
公開日2021-03-31
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release
To Be Published
6W9Z
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BU of 6w9z by Molmil
De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release
分子名称: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, De novo designed receptor transmembrane domain ProMP C2.1
著者Call, M.J, Call, M.E, Chandler, N.J, Nguyen, J.V, Trenker, R.
登録日2020-03-24
公開日2021-03-31
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release
To Be Published
2V2H
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BU of 2v2h by Molmil
The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM
分子名称: 2-PHOSPHOGLYCOLIC ACID, CHLORIDE ION, TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL
著者Alahuhta, M, Casteleijn, M.G, Neubauer, P, Wierenga, R.K.
登録日2007-06-06
公開日2008-02-19
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.18 Å)
主引用文献Structural Studies Show that the A178L Mutation in the C-Terminal Hinge of the Catalytic Loop-6 of Triosephosphate Isomerase (Tim) Induces a Closed-Like Conformation in Dimeric and Monomeric Tim.
Acta Crystallogr.,Sect.D, 64, 2008
1SPQ
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BU of 1spq by Molmil
Understanding protein lids: Structural analysis of active hinge mutants in triosephosphate isomerase
分子名称: DI(HYDROXYETHYL)ETHER, Triosephosphate isomerase
著者Kursula, I, Salin, M, Sun, J, Norledge, B.V, Haapalainen, A.M, Sampson, N.S, Wierenga, R.K.
登録日2004-03-17
公開日2004-08-24
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase
Protein Eng.Des.Sel., 17, 2004
1SSG
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BU of 1ssg by Molmil
Understanding protein lids: Structural analysis of active hinge mutants in triosephosphate isomerase
分子名称: 2-PHOSPHOGLYCOLIC ACID, GLYCEROL, SULFATE ION, ...
著者Kursula, I, Salin, M, Sun, J, Norledge, B.V, Haapalainen, A.M, Sampson, N.S, Wierenga, R.K.
登録日2004-03-24
公開日2004-08-24
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase
Protein Eng.Des.Sel., 17, 2004

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