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PDB: 589 results
4L28
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BU of 4l28 by Molmil
Crystal structure of delta516-525 human cystathionine beta-synthase D444N mutant containing C-terminal 6xHis tag
Descriptor: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE
Authors:Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez, L.A.
Deposit date:2013-06-04
Release date:2013-09-18
Last modified:2013-10-16
Method:X-RAY DIFFRACTION (2.626 Å)
Cite:Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration.
Proc.Natl.Acad.Sci.USA, 110, 2013
2W79
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BU of 2w79 by Molmil
Establishing wild-type levels of catalytic activity on natural and artificial (ba)8-barrel protein scaffolds
Descriptor: 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO) METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE, CHLORIDE ION
Authors:Claren, J, Malisi, C, Hocker, B, Sterner, R.
Deposit date:2008-12-21
Release date:2009-02-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Establishing Wild-Type Levels of Catalytic Activity on Natural and Artificial (Beta Alpha)8- Barrel Protein Scaffolds.
Proc.Natl.Acad.Sci.USA, 106, 2009
2PAD
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BU of 2pad by Molmil
BINDING OF CHLOROMETHYL KETONE SUBSTRATE ANALOGUES TO CRYSTALLINE PAPAIN
Descriptor: CYSTEINE, PAPAIN
Authors:Drenth, J, Kalk, K.H, Swen, H.M.
Deposit date:1976-11-01
Release date:1977-04-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding of chloromethyl ketone substrate analogues to crystalline papain.
Biochemistry, 15, 1976
1XQC
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BU of 1xqc by Molmil
X-ray structure of ERalpha LBD bound to a tetrahydroisoquinoline SERM ligand at 2.05A resolution
Descriptor: (1S)-1-{4-[(9AR)-OCTAHYDRO-2H-PYRIDO[1,2-A]PYRAZIN-2-YL]PHENYL}-2-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLIN-6-OL, Estrogen receptor
Authors:Renaud, J, Bischoff, S.F, Buhl, T, Floersheim, P, Fournier, B, Geiser, M, Halleux, C, Kallen, J, Keller, H.J, Ramage, P.
Deposit date:2004-10-12
Release date:2005-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Selective Estrogen Receptor Modulators with Conformationally Restricted Side Chains. Synthesis and Structure-Activity Relationship of ERalpha-Selective Tetrahydroisoquinoline Ligands
J.Med.Chem., 48, 2005
5TQ4
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BU of 5tq4 by Molmil
Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
Descriptor: 6-(2-ethyl-4-hydroxyphenyl)-1H-indazole-3-carboxamide, Tyrosine-protein kinase JAK2
Authors:Chrencik, J, Jones, P.
Deposit date:2016-10-23
Release date:2017-01-11
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J. Med. Chem., 60, 2017
5TQ6
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BU of 5tq6 by Molmil
Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
Descriptor: Tyrosine-protein kinase JAK2, {(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone
Authors:Chrencik, J, Jones, P.
Deposit date:2016-10-23
Release date:2017-01-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J. Med. Chem., 60, 2017
5TQ3
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BU of 5tq3 by Molmil
Design and Synthesis of a pan-JAK kinase inhibitor clinical candidate (PF-06263276) suitable for the treatment of inflammatory diseases of the lungs and skin
Descriptor: 4-[3-(1H-benzimidazol-2-yl)-1H-indazol-6-yl]-3-ethylphenol, Tyrosine-protein kinase JAK2
Authors:Chrencik, J, Jones, P.
Deposit date:2016-10-23
Release date:2017-01-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J. Med. Chem., 60, 2017
5TQ8
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BU of 5tq8 by Molmil
Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
Descriptor: Tyrosine-protein kinase JAK2, {2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-2H-indazol-3-yl]-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl}[5-(piperidin-1-yl)pyrazin-2-yl]methanone
Authors:Chrencik, J, Jones, P.
Deposit date:2016-10-23
Release date:2017-01-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J. Med. Chem., 60, 2017
5TQ7
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BU of 5tq7 by Molmil
Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
Descriptor: Tyrosine-protein kinase JAK2, {(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3R)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone
Authors:Chrencik, J, Jones, P.
Deposit date:2016-10-23
Release date:2017-01-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J. Med. Chem., 60, 2017
5TQ5
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BU of 5tq5 by Molmil
Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
Descriptor: 6-(2-ethyl-4-hydroxyphenyl)-N-(6-methylpyridin-3-yl)-1H-indazole-3-carboxamide, Tyrosine-protein kinase JAK2
Authors:Chrencik, J, Jones, P.
Deposit date:2016-10-23
Release date:2017-01-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J. Med. Chem., 60, 2017
1PAD
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BU of 1pad by Molmil
Binding of chloromethyl ketone substrate analogues to crystalline papain
Descriptor: ACETYL-ALA-ALA-PHE-ALA-CHLOROMETHYLKETONE INHIBITOR, PAPAIN
Authors:Drenth, J, Kalk, K.H, Swen, H.M.
Deposit date:1976-11-01
Release date:1977-04-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding of chloromethyl ketone substrate analogues to crystalline papain.
Biochemistry, 15, 1976
5PAD
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BU of 5pad by Molmil
BINDING OF CHLOROMETHYL KETONE SUBSTRATE ANALOGUES TO CRYSTALLINE PAPAIN
Descriptor: PAPAIN, PHQ-GLY-PHE-GLY-CHLOROMETHYLKETONE INHIBITOR
Authors:Drenth, J, Kalk, K.H, Swen, H.M.
Deposit date:1976-11-01
Release date:1977-04-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding of chloromethyl ketone substrate analogues to crystalline papain.
Biochemistry, 15, 1976
8CIM
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BU of 8cim by Molmil
BA.2-07 FAB IN COMPLEX WITH SARS-COV-2 BA.2.12.1 SPIKE GLYCOPROTEIN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BA.2-07 FAB HEAVY CHAIN, ...
Authors:Duyvesteyn, H.M.E, Ren, J, Stuart, D.I, Fry, E.E.
Deposit date:2023-02-10
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Isolation of a pair of potent broadly neutralizing mAb binding to RBD and SD1 domains of SARS-CoV-2
Res Sq, 2023
6RZ3
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BU of 6rz3 by Molmil
Crystal structure of a complex between the DNA-binding domain of p53 and the carboxyl-terminal conserved region of iASPP
Descriptor: Cellular tumor antigen p53, RelA-associated inhibitor, ZINC ION
Authors:Chen, S, Ren, J, Jones, E.Y, Lu, X.
Deposit date:2019-06-12
Release date:2019-10-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (4.23 Å)
Cite:iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.
Proc.Natl.Acad.Sci.USA, 116, 2019
5HNS
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BU of 5hns by Molmil
Structure of glycosylated NPC1 luminal domain C
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Niemann-Pick C1 protein, ...
Authors:Zhao, Y, Ren, J, Harlos, K, Stuart, D.I.
Deposit date:2016-01-18
Release date:2016-02-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions.
Febs Lett., 590, 2016
7ND4
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BU of 7nd4 by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-88 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-88 Fab heavy chain, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7ND3
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BU of 7nd3 by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-40 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-40 heavy chain, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7ND8
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BU of 7nd8 by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-384 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-384 Fab heavy chain, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7NDC
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BU of 7ndc by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein (all RBD down) in complex with COVOX-159
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-159 Fab light chain, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7ND7
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BU of 7nd7 by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-316 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7ND9
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BU of 7nd9 by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein (one RBD up) in complex with COVOX-253H55L Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7NDD
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BU of 7ndd by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein (one RBD up) in complex with COVOX-159
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-159 Fab heavy chain, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7NDA
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BU of 7nda by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein (all RBD down) in complex with COVOX-253H55L Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7ND5
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BU of 7nd5 by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-150 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-150 Fab heavy chain, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7ND6
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BU of 7nd6 by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-40 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-158 Fab heavy chain, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021

222624

數據於2024-07-17公開中

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