4Z2A
| Crystal structure of unglycosylated apo human furin @1.89A | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Furin, ... | Authors: | Gampe, R.T, Pearce, K, Reid, R. | Deposit date: | 2015-03-29 | Release date: | 2016-05-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | BacMam production and crystal structure of nonglycosylated apo human furin at 1.89A resolution Acta Crystallogr.,Sect.F, 2019
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7LCU
| X-ray structure of Furin bound to BOS-318, a small molecule inhibitor | Descriptor: | (1-{[2-(3,5-dichlorophenyl)-6-{[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]oxy}pyridin-4-yl]methyl}piperidin-4-yl)acetic acid, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Campobasso, N, Reid, R. | Deposit date: | 2021-01-11 | Release date: | 2022-01-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease. Cell Chem Biol, 29, 2022
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