3H98
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![BU of 3h98 by Molmil](/molmil-images/mine/3h98) | Crystal structure of HCV NS5b 1b with (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyrimidine derivative | 分子名称: | GLYCEROL, N-{3-[5-hydroxy-8-(3-methylbutyl)-7-oxo-7,8-dihydroimidazo[1,2-a]pyrimidin-6-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase | 著者 | Wang, G, Lei, H, Wang, X, Das, D, Mackinnon, C, Montalbetti, C.A.G, Mears, R, Gai, X, Bailey, S, Ruhrmund, D, Hooi, L, Misialek, S, Rajagopalan, R, Cheng, R.K.Y, Barker, J.L, Felicetti, B, Stoycheva, A, Buckman, B, Kossen, K, Seiwert, S, Beigelmana, L. | 登録日 | 2009-04-30 | 公開日 | 2009-10-13 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives. Bioorg.Med.Chem.Lett., 19, 2009
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1SGU
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![BU of 1sgu by Molmil](/molmil-images/mine/1sgu) | Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease | 分子名称: | N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, POL polyprotein | 著者 | Clemente, J.C, Moose, R.E, Hemrajani, R, Govindasamy, L, Reutzel, R, Mckenna, R, Abandje-McKenna, M, Goodenow, M.M, Dunn, B.M. | 登録日 | 2004-02-24 | 公開日 | 2004-10-05 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Comparing the Accumulation of Active- and Nonactive-Site Mutations in the HIV-1 Protease. Biochemistry, 43, 2004
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1SH9
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![BU of 1sh9 by Molmil](/molmil-images/mine/1sh9) | Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease | 分子名称: | POL polyprotein, RITONAVIR | 著者 | Clemente, J.C, Moose, R.E, Hemrajani, R, Govindasamy, L, Reutzel, R, McKenna, R, Abanje-McKenna, M, Goodenow, M.M, Dunn, B.M. | 登録日 | 2004-02-25 | 公開日 | 2004-10-05 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Comparing the Accumulation of Active- and Nonactive-Site Mutations in the HIV-1 Protease. Biochemistry, 43, 2004
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8WSV
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![BU of 8wsv by Molmil](/molmil-images/mine/8wsv) | |
8XB7
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![BU of 8xb7 by Molmil](/molmil-images/mine/8xb7) | |
5KR8
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![BU of 5kr8 by Molmil](/molmil-images/mine/5kr8) | (4~{S},6~{S})-4-[2,4-bis(fluoranyl)phenyl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine (compound 5) bound to BACE1 | 分子名称: | (4~{S},6~{S})-4-[2,4-bis(fluoranyl)phenyl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine, Beta-secretase 1, IODIDE ION | 著者 | Lewis, H.A, Wu, Y.J, Rajamani, R, Thompson, L.A. | 登録日 | 2016-07-07 | 公開日 | 2016-09-07 | 最終更新日 | 2016-10-05 | 実験手法 | X-RAY DIFFRACTION (2.118 Å) | 主引用文献 | Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine beta-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors. J.Med.Chem., 59, 2016
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1D5D
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1D5H
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![BU of 1d5h by Molmil](/molmil-images/mine/1d5h) | Rnase s(f8a). mutant ribonucleasE S. | 分子名称: | RNASE S, S PEPTIDE, SULFATE ION | 著者 | Ratnaparkhi, G.S, Varadarajan, R. | 登録日 | 1999-10-07 | 公開日 | 1999-10-20 | 最終更新日 | 2018-03-14 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Thermodynamic and structural studies of cavity formation in proteins suggest that loss of packing interactions rather than the hydrophobic effect dominates the observed energetics. Biochemistry, 39, 2000
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2RLN
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![BU of 2rln by Molmil](/molmil-images/mine/2rln) | |
4ZNP
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![BU of 4znp by Molmil](/molmil-images/mine/4znp) | The structure of A pfI Riboswitch Bound to ZMP | 分子名称: | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, MAGNESIUM ION, pfI Riboswitch | 著者 | Ren, A, Patel, D.J, Rajashankar, R.K. | 登録日 | 2015-05-05 | 公開日 | 2015-08-26 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Global RNA Fold and Molecular Recognition for a pfl Riboswitch Bound to ZMP, a Master Regulator of One-Carbon Metabolism. Structure, 23, 2015
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1J80
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![BU of 1j80 by Molmil](/molmil-images/mine/1j80) | Osmolyte Stabilization of RNase | 分子名称: | RIBONUCLEASE PANCREATIC, SULFATE ION | 著者 | Ratnaparkhi, G.S, Varadarajan, R. | 登録日 | 2001-05-19 | 公開日 | 2001-06-06 | 最終更新日 | 2017-10-04 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Osmolytes stabilize ribonuclease S by stabilizing its fragments S protein and S peptide to compact folding-competent states. J.Biol.Chem., 276, 2001
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1A19
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![BU of 1a19 by Molmil](/molmil-images/mine/1a19) | BARSTAR (FREE), C82A MUTANT | 分子名称: | BARSTAR | 著者 | Ratnaparkhi, G.S, Varadarajan, R. | 登録日 | 1997-12-25 | 公開日 | 1998-04-08 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Discrepancies between the NMR and X-ray structures of uncomplexed barstar: analysis suggests that packing densities of protein structures determined by NMR are unreliable. Biochemistry, 37, 1998
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1J82
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![BU of 1j82 by Molmil](/molmil-images/mine/1j82) | Osmolyte Stabilization of RNase | 分子名称: | RIBONUCLEASE PANCREATIC, SULFATE ION | 著者 | Ratnaparkhi, G.S, Varadarajan, R. | 登録日 | 2001-05-19 | 公開日 | 2001-06-06 | 最終更新日 | 2017-10-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Osmolytes stabilize ribonuclease S by stabilizing its fragments S protein and S peptide to compact folding-competent states. J.Biol.Chem., 276, 2001
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1NKG
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![BU of 1nkg by Molmil](/molmil-images/mine/1nkg) | Rhamnogalacturonan lyase from Aspergillus aculeatus | 分子名称: | CALCIUM ION, Rhamnogalacturonase B, SULFATE ION | 著者 | McDonough, M.A, Kadirvelraj, R, Harris, P, Poulsen, J.C, Larsen, S. | 登録日 | 2003-01-03 | 公開日 | 2004-05-25 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Rhamnogalacturonan lyase reveals a unique three-domain modular structure for polysaccharide lyase family 4. Febs Lett., 565, 2004
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1J7Z
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1J81
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![BU of 1j81 by Molmil](/molmil-images/mine/1j81) | Osmolyte Stabilization of RNase | 分子名称: | RIBONUCLEASE PANCREATIC, SULFATE ION | 著者 | Ratnaparkhi, G.S, Varadarajan, R. | 登録日 | 2001-05-19 | 公開日 | 2001-06-06 | 最終更新日 | 2017-11-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Osmolytes stabilize ribonuclease S by stabilizing its fragments S protein and S peptide to compact folding-competent states. J.Biol.Chem., 276, 2001
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1D5E
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1FEV
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![BU of 1fev by Molmil](/molmil-images/mine/1fev) | |
1CJQ
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1XP8
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![BU of 1xp8 by Molmil](/molmil-images/mine/1xp8) | |
5VCR
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![BU of 5vcr by Molmil](/molmil-images/mine/5vcr) | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase with bound uranium dioxide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, CHLORIDE ION, ... | 著者 | Sanders, J.H, Kadirvelraj, R, Wood, Z.A. | 登録日 | 2017-03-31 | 公開日 | 2018-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.992 Å) | 主引用文献 | HumanN-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1CJR
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2RNS
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![BU of 2rns by Molmil](/molmil-images/mine/2rns) | REFINEMENT OF THE CRYSTAL STRUCTURE OF RIBONUCLEASE S. COMPARISON WITH AND BETWEEN THE VARIOUS RIBONUCLEASE A STRUCTURES | 分子名称: | RIBONUCLEASE S, SULFATE ION | 著者 | Kim, E.E, Varadarajan, R, Wyckoff, H.W, Richards, F.M. | 登録日 | 1992-02-19 | 公開日 | 1994-01-31 | 最終更新日 | 2019-08-14 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Refinement of the crystal structure of ribonuclease S. Comparison with and between the various ribonuclease A structures. Biochemistry, 31, 1992
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5VCM
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![BU of 5vcm by Molmil](/molmil-images/mine/5vcm) | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase with bound UDP and Manganese | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, ... | 著者 | Sanders, J.H, Kadirvelraj, R, Wood, Z.A. | 登録日 | 2017-03-31 | 公開日 | 2018-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | 主引用文献 | HumanN-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3CWG
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![BU of 3cwg by Molmil](/molmil-images/mine/3cwg) | Unphosphorylated mouse STAT3 core fragment | 分子名称: | Signal transducer and activator of transcription 3 | 著者 | Ren, Z, Mao, X, Mertens, C, Krishnaraj, R, Qin, J, Mandal, P.K, Romanowshi, M.J, McMurray, J.S. | 登録日 | 2008-04-21 | 公開日 | 2008-07-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Crystal structure of unphosphorylated STAT3 core fragment. Biochem.Biophys.Res.Commun., 374, 2008
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