8EDH
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4U3X
| Structure of a human VH antibody domain binding to the cleft of hen egg lysozyme | 分子名称: | 1,2-ETHANEDIOL, Human VH domain antibody, Lysozyme C | 著者 | Rouet, R, Langley, D.B, Christ, D. | 登録日 | 2014-07-23 | 公開日 | 2015-03-11 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies J.Biol.Chem., 290, 2015
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8DSD
| Human NAMPT in complex with substrate NAM and small molecule activator NP-A1-S | 分子名称: | (3S)-1-[2-(4-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-N-{[4-(methylsulfanyl)phenyl]methyl}piperidine-3-carboxamide, CHLORIDE ION, GLYCEROL, ... | 著者 | Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. | 登録日 | 2022-07-22 | 公開日 | 2023-03-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.429 Å) | 主引用文献 | Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
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4TVQ
| CCM3 in complex with CCM2 LD-like motif | 分子名称: | Cerebral cavernous malformations 2 protein, Cerebral cavernous malformations 3 protein | 著者 | Li, X, Zhang, R, Fisher, O.S, Boggon, T.J. | 登録日 | 2014-06-27 | 公開日 | 2015-03-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation. J.Cell Biol., 208, 2015
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8DSH
| Human NAMPT in complex with quercitrin and AMPcP | 分子名称: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, Nicotinamide phosphoribosyltransferase, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | 著者 | Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. | 登録日 | 2022-07-22 | 公開日 | 2023-03-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
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8DSC
| Human NAMPT in complex with substrate NAM and small molecule activator NP-A1-R | 分子名称: | (3R)-1-[2-(4-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-N-{[4-(methylsulfanyl)phenyl]methyl}piperidine-3-carboxamide, CHLORIDE ION, GLYCEROL, ... | 著者 | Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. | 登録日 | 2022-07-22 | 公開日 | 2023-03-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.321 Å) | 主引用文献 | Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
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8DTJ
| Human NAMPT in complex with small molecule activator ZN-43-S | 分子名称: | (3S)-N-[(1-benzothiophen-5-yl)methyl]-1-{2-[4-(trifluoromethyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidine-3-carboxamide, CHLORIDE ION, GLYCEROL, ... | 著者 | Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. | 登録日 | 2022-07-25 | 公開日 | 2023-03-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.118 Å) | 主引用文献 | Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
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8DSE
| Human NAMPT in complex with substrate NAM and activator quercitrin | 分子名称: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, CHLORIDE ION, NICOTINAMIDE, ... | 著者 | Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. | 登録日 | 2022-07-22 | 公開日 | 2023-03-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.428 Å) | 主引用文献 | Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
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8DSI
| Human NAMPT in complex with substrate NAM | 分子名称: | CHLORIDE ION, GLYCEROL, NICOTINAMIDE, ... | 著者 | Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. | 登録日 | 2022-07-22 | 公開日 | 2023-03-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
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4TYG
| Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase | 分子名称: | ACETATE ION, Fibroblast growth factor receptor 4 | 著者 | Lesca, E, Lammens, A, Huber, R, Augustin, M. | 登録日 | 2014-07-08 | 公開日 | 2014-09-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural analysis of the human fibroblast growth factor receptor 4 kinase. J.Mol.Biol., 426, 2014
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4TXN
| Crystal structure of uridine phosphorylase from Schistosoma mansoni in complex with 5-fluorouracil | 分子名称: | 5-FLUOROURACIL, SULFATE ION, Uridine phosphorylase | 著者 | Marinho, A, Torini, J, Romanello, L, Cassago, A, DeMarco, R, Brandao-Neto, J, Pereira, H.M. | 登録日 | 2014-07-03 | 公開日 | 2015-10-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Analysis of two Schistosoma mansoni uridine phosphorylases isoforms suggests the emergence of a protein with a non-canonical function. Biochimie, 125, 2016
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4U2H
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4TX1
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4TXH
| Crystal structure of uridine phosphorylase from Schistosoma mansoni in APO form | 分子名称: | SULFATE ION, Uridine phosphorylase | 著者 | Torini, J, Romanello, L, Marinho, A, Brandao-Neto, J, Cassago, A, DeMarco, R, Pereira, H.M. | 登録日 | 2014-07-03 | 公開日 | 2015-10-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.892 Å) | 主引用文献 | Analysis of two Schistosoma mansoni uridine phosphorylases isoforms suggests the emergence of a protein with a non-canonical function. Biochimie, 125, 2016
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4TYI
| Structural analysis of the human Fibroblast Growth Factor Receptor 4 | 分子名称: | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one, Fibroblast growth factor receptor 4 | 著者 | Lesca, E, Lammens, A, Huber, R, Augustin, M. | 登録日 | 2014-07-08 | 公開日 | 2014-09-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural analysis of the human fibroblast growth factor receptor 4 kinase. J.Mol.Biol., 426, 2014
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8E0N
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8E0M
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8E5T
| Yeast co-transcriptional Noc1-Noc2 RNP assembly checkpoint intermediate | 分子名称: | 25S ribosomal RNA, 5.8S ribosomal RNA, 60S ribosomal protein L13-A, ... | 著者 | Sanghai, Z.A, Piwowarczyk, R, Vanden Broeck, A, Klinge, S. | 登録日 | 2022-08-22 | 公開日 | 2023-04-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | A co-transcriptional ribosome assembly checkpoint controls nascent large ribosomal subunit maturation. Nat.Struct.Mol.Biol., 30, 2023
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8E0O
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8E12
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8DV3
| Crystal structure of human CD1b presenting Phosphatidylinositol C34:1 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Farquhar, R, Rossjohn, J, Shahine, A. | 登録日 | 2022-07-28 | 公開日 | 2023-04-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | alpha beta T-cell receptor recognition of self-phosphatidylinositol presented by CD1b. J.Biol.Chem., 299, 2023
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4U8G
| Crystal structure of 2-keto-3-deoxy-D-gluconate dehydrogenase from Streptococcus agalactiae | 分子名称: | Putative uncharacterized protein gbs1891 | 著者 | Maruyama, Y, Oiki, S, Takase, R, Mikami, B, Murata, K, Hashimoto, W. | 登録日 | 2014-08-03 | 公開日 | 2014-12-24 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Metabolic Fate of Unsaturated Glucuronic/Iduronic Acids from Glycosaminoglycans: MOLECULAR IDENTIFICATION AND STRUCTURE DETERMINATION OF STREPTOCOCCAL ISOMERASE AND DEHYDROGENASE. J.Biol.Chem., 290, 2015
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8DV4
| Crystal structure of the BC8B TCR-CD1b-PI complex | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Farquhar, R, Rossjohn, J, Shahine, A. | 登録日 | 2022-07-28 | 公開日 | 2023-04-19 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | alpha beta T-cell receptor recognition of self-phosphatidylinositol presented by CD1b. J.Biol.Chem., 299, 2023
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8E0L
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8E6L
| X-ray structure of the Deinococcus radiodurans Nramp/MntH divalent transition metal transporter D296A mutant in an inward-open, manganese-bound state | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, Divalent metal cation transporter MntH, ... | 著者 | Ray, S, Gaudet, R. | 登録日 | 2022-08-22 | 公開日 | 2023-05-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | High-resolution structures with bound Mn 2+ and Cd 2+ map the metal import pathway in an Nramp transporter. Elife, 12, 2023
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