9AXX
| Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9AXH
| Crystal structure of KSR1/MEK1 complex heterotetramer with NST-628 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9AXC
| Activated CRAF/MEK heterotetramer from focused refinement of CRAF/MEK/14-3-3 complex | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, GST26/CRAF chimera, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide | 著者 | Quade, B, Cohen, S.E, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.16 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9AXM
| Crystal structure of ARAF/MEK1 complex with NST-628 and a RAF dimer | 分子名称: | 1,2-ETHANEDIOL, Dual specificity mitogen-activated protein kinase kinase 1, GLYCEROL, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9AYA
| Crystal structure of CRAF/MEK complex with NST-628 and active RAF dimer | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-07 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9AXA
| CryoEM structure of activated CRAF/MEK/14-3-3 complex with NST-628 | 分子名称: | 14-3-3 protein sigma, Dual specificity mitogen-activated protein kinase kinase 1, GST26/CRAF chimera, ... | 著者 | Quade, B, Cohen, S.E, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.36 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9AY7
| Crystal structure of CRAF/MEK1 complex with NST-628 and inactive RAF | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-07 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9AXY
| Crystal structure of BRAF/MEK complex with NST-628 and inactive RAF | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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7U5T
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7U5S
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7U5U
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8S9P
| 1:1:1 agrin/LRP4/MuSK complex | 分子名称: | Agrin, Low-density lipoprotein receptor-related protein 4, Muscle, ... | 著者 | Xie, T, Xu, G.J, Liu, Y, Quade, B, Lin, W.C, Bai, X.C. | 登録日 | 2023-03-29 | 公開日 | 2023-05-17 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural insights into the assembly of the agrin/LRP4/MuSK signaling complex. Proc.Natl.Acad.Sci.USA, 120, 2023
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2MSV
| Solution structure of the MLKL N-terminal domain | 分子名称: | Mixed lineage kinase domain-like protein | 著者 | Su, L, Rizo, J, Quade, B, Wang, H, Sun, L, Wang, X. | 登録日 | 2014-08-07 | 公開日 | 2014-09-24 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | A Plug Release Mechanism for Membrane Permeation by MLKL. Structure, 22, 2014
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