4BMD
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![BU of 4bmd by Molmil](/molmil-images/mine/4bmd) | Crystal structure of S.pombe Rad4 BRCT3,4 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, S-M CHECKPOINT CONTROL PROTEIN RAD4 | Authors: | Meng, Q, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. | Deposit date: | 2013-05-07 | Release date: | 2013-10-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013
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4BU0
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![BU of 4bu0 by Molmil](/molmil-images/mine/4bu0) | Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide | Descriptor: | ACETATE ION, DNA REPAIR PROTEIN RHP9, GLYCEROL, ... | Authors: | Qu, M, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. | Deposit date: | 2013-06-19 | Release date: | 2013-10-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013
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4BU1
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![BU of 4bu1 by Molmil](/molmil-images/mine/4bu1) | Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide | Descriptor: | 1,2-ETHANEDIOL, DNA REPAIR PROTEIN RHP9, GLYCEROL, ... | Authors: | Qu, M, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. | Deposit date: | 2013-06-19 | Release date: | 2013-10-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013
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1AH8
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![BU of 1ah8 by Molmil](/molmil-images/mine/1ah8) | |
1AH6
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![BU of 1ah6 by Molmil](/molmil-images/mine/1ah6) | |
2YI0
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![BU of 2yi0 by Molmil](/molmil-images/mine/2yi0) | Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. | Descriptor: | 4-CHLORO-6-[5-(4-METHOXYPHENYL)-1,2,3-THIADIAZOL-4-YL]BENZENE-1,3-DIOL, HEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION | Authors: | Roe, S.M, Prodromou, C, Pearl, L.H. | Deposit date: | 2011-05-10 | Release date: | 2012-05-16 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Co-Crystalization and in Vitro Biological Characterization of 5-Aryl-4-(5-Substituted-2-4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors. Plos One, 7, 2012
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1Q2Z
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![BU of 1q2z by Molmil](/molmil-images/mine/1q2z) | The 3D solution structure of the C-terminal region of Ku86 | Descriptor: | ATP-dependent DNA helicase II, 80 kDa subunit | Authors: | Harris, R, Esposito, D, Sankar, A, Maman, J.D, Hinks, J.A, Pearl, L.H, Driscoll, P.C. | Deposit date: | 2003-07-28 | Release date: | 2004-01-13 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The 3D Solution Structure of the C-terminal Region of Ku86 (Ku86CTR) J.Mol.Biol., 335, 2004
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3ZDI
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![BU of 3zdi by Molmil](/molmil-images/mine/3zdi) | Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Inhibitor 7d | Descriptor: | 3,6-Diamino-4-(2-chlorophenyl)thieno[2,3-b]pyridine-2,5-dicarbonitrile, AXIN-1, GLYCOGEN SYNTHASE KINASE-3 BETA, ... | Authors: | Oberholzer, A.E, Pearl, L.H. | Deposit date: | 2012-11-27 | Release date: | 2012-12-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.645 Å) | Cite: | 3,6-Diamino-4-(2-Halophenyl)-2-Benzoylthieno(2,3-B) Pyridine-5-Carbonitriles are Selective Inhibitors of Plasmodium Falciparum Glycogen Synthase Kinase-3 (Pfgsk-3) J.Med.Chem., 56, 2013
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1OE6
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![BU of 1oe6 by Molmil](/molmil-images/mine/1oe6) | Xenopus SMUG1, an anti-mutator uracil-DNA Glycosylase | Descriptor: | 5'-D(*CP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*G)-3', 5'-D(*CP*GP*GP*AP*CP*TP*3DRP*AP*CP*GP*GP*G)-3', 5-HYDROXYMETHYL URACIL, ... | Authors: | Wibley, J.E.A, Pearl, L.H. | Deposit date: | 2003-03-19 | Release date: | 2003-07-11 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structure and Specificity of the Vertebrate Anti-Mutator Uracil-DNA Glycosylase Smug1 Mol.Cell, 11, 2003
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1O9U
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![BU of 1o9u by Molmil](/molmil-images/mine/1o9u) | |
1ODG
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![BU of 1odg by Molmil](/molmil-images/mine/1odg) | Very-short-patch DNA repair endonuclease bound to its reaction product site | Descriptor: | 5'-D(*TP*AP*GP*GP*CP*5CM*TP*GP*GP*AP*TP*CP)-3', DNA MISMATCH ENDONUCLEASE, ZINC ION | Authors: | Bunting, K.A, Roe, S.M, Headley, A, Brown, T, Savva, R, Pearl, L.H. | Deposit date: | 2003-02-19 | Release date: | 2003-03-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of the Escherichia Coli Dcm Very-Short-Patch DNA Repair Endonuclease Bound to its Reaction Product-Site in a DNA Superhelix Nucleic Acids Res., 31, 2003
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4B7T
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![BU of 4b7t by Molmil](/molmil-images/mine/4b7t) | Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Leucettine L4 | Descriptor: | (5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-methyl-2-(propan-2-ylamino)imidazol-4-one, AXIN-1, GLYCOGEN SYNTHASE KINASE-3 BETA | Authors: | Oberholzer, A.E, Pearl, L.H. | Deposit date: | 2012-08-22 | Release date: | 2013-01-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.772 Å) | Cite: | Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B. J.Med.Chem., 55, 2012
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3ZVN
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![BU of 3zvn by Molmil](/molmil-images/mine/3zvn) | The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase | Descriptor: | 5'-D(*GP*TP*CP*AP*CP)-3', ADENOSINE-5'-DIPHOSPHATE, BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, ... | Authors: | Garces, F, Pearl, L.H, Oliver, A.W. | Deposit date: | 2011-07-25 | Release date: | 2011-11-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase. Mol. Cell, 44, 2011
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1OE5
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![BU of 1oe5 by Molmil](/molmil-images/mine/1oe5) | Xenopus SMUG1, an anti-mutator uracil-DNA Glycosylase | Descriptor: | 2'-DEOXYURIDINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-D(*CP*3DRP*GP*GP*AP*CP*TP*3DRP*AP*CP*GP*GP*GP)-3', ... | Authors: | Wibley, J.E.A, Pearl, L.H. | Deposit date: | 2003-03-19 | Release date: | 2003-07-11 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and Specificity of the Vertebrate Anti-Mutator Uracil-DNA Glycosylase Smug1 Mol.Cell, 11, 2003
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4AV1
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![BU of 4av1 by Molmil](/molmil-images/mine/4av1) | Crystal structure of the human PARP-1 DNA binding domain in complex with DNA | Descriptor: | 5'-D(*AP*AP*GP*TP*GP*TP*TP*GP*CP*AP*TP*TP)-3', 5'-D(*TP*AP*AP*TP*GP*CP*AP*AP*CP*AP*CP*TP)-3', POLY [ADP-RIBOSE] POLYMERASE 1, ... | Authors: | Ali, A.A.E, Timinszky, G, Arribas-Bosacoma, R, Kozlowski, M, Hassa, P.O, Hassler, M, Ladurner, A.G, Pearl, L.H, Oliver, A.W. | Deposit date: | 2012-05-23 | Release date: | 2012-06-13 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The Zinc-Finger Domains of Parp1 Cooperate to Recognise DNA Strand-Breaks Nat.Struct.Mol.Biol., 19, 2012
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3ZVL
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![BU of 3zvl by Molmil](/molmil-images/mine/3zvl) | The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase | Descriptor: | ACETATE ION, BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, CHLORIDE ION, ... | Authors: | Garces, F, Pearl, L.H, Oliver, A.W. | Deposit date: | 2011-07-25 | Release date: | 2011-11-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The Structural Basis for Substrate Recognition by Mammalian Polynucleotide Kinase 3' Phosphatase. Mol.Cell, 44, 2011
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4BB7
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![BU of 4bb7 by Molmil](/molmil-images/mine/4bb7) | Crystal structure of the yeast Rsc2 BAH domain | Descriptor: | CHLORIDE ION, CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC2, GLYCEROL, ... | Authors: | Chambers, A.L, Pearl, L.H, Oliver, A.W, Downs, J.A. | Deposit date: | 2012-09-20 | Release date: | 2013-08-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The Bah Domain of Rsc2 is a Histone H3 Binding Domain. Nucleic Acids Res., 41, 2013
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1OE4
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![BU of 1oe4 by Molmil](/molmil-images/mine/1oe4) | Xenopus SMUG1, an anti-mutator uracil-DNA Glycosylase | Descriptor: | 5'-D(*CP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*G)-3', 5'-D(*CP*GP*GP*AP*CP*TP*3DR*AP*CP*GP*GP*G)-3', GLYCEROL, ... | Authors: | Wibley, J.E.A, Pearl, L.H. | Deposit date: | 2003-03-19 | Release date: | 2003-07-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and Specificity of the Vertebrate Anti-Mutator Uracil-DNA Glycosylase Smug1 Mol.Cell, 11, 2003
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3ZVM
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![BU of 3zvm by Molmil](/molmil-images/mine/3zvm) | The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-D(*GP*TP*CP*AP*CP)-3', ACETATE ION, ... | Authors: | Garces, F, Pearl, L.H, Oliver, A.W. | Deposit date: | 2011-07-25 | Release date: | 2011-11-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.997 Å) | Cite: | The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase. Mol. Cell, 44, 2011
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4BA9
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![BU of 4ba9 by Molmil](/molmil-images/mine/4ba9) | The structural basis for the coordination of Y-family Translesion DNA Polymerases by Rev1 | Descriptor: | DNA POLYMERASE KAPPA, DNA REPAIR PROTEIN REV1, MAGNESIUM ION, ... | Authors: | Grummitt, C.G, Kilkenny, M.L, Frey, A, Roe, S.M, Oliver, A.W, Sale, J.E, Pearl, L.H. | Deposit date: | 2012-09-12 | Release date: | 2013-09-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | The Structural Basis for the Coordination of Y- Family Translesion DNA Polymerases by Rev1 To be Published
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2BYF
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![BU of 2byf by Molmil](/molmil-images/mine/2byf) | NMR solution structure of phospholipase c epsilon RA 2 domain | Descriptor: | PHOSPHOLIPASE C, EPSILON 1 | Authors: | Bunney, T.D, Harris, R, Gandarillas, N.L, Josephs, M.B, Roe, S.M, Paterson, H.F, Rodrigues-Lima, F, Esposito, D, Gieschik, P, Pearl, L.H, Driscoll, P.C, Katan, M. | Deposit date: | 2005-08-01 | Release date: | 2006-02-22 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structural and Mechanistic Insights Into Ras Association Domains of Phospholipase C Epsilon. Mol.Cell, 21, 2006
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2BYE
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![BU of 2bye by Molmil](/molmil-images/mine/2bye) | NMR solution structure of phospholipase c epsilon RA 1 domain | Descriptor: | PHOSPHOLIPASE C, EPSILON 1 | Authors: | Bunney, T.D, Harris, R, Gandarillas, N.L, Josephs, M.B, Roe, S.M, Paterson, H.F, Rodrigues-Lima, F, Esposito, D, Gieschik, P, Pearl, L.H, Driscoll, P.C, Katan, M. | Deposit date: | 2005-08-01 | Release date: | 2006-02-22 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structural and Mechanistic Insights Into Ras Association Domains of Phospholipase C Epsilon. Mol.Cell, 21, 2006
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2BRF
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![BU of 2brf by Molmil](/molmil-images/mine/2brf) | |
2CN8
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![BU of 2cn8 by Molmil](/molmil-images/mine/2cn8) | |
2CN5
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![BU of 2cn5 by Molmil](/molmil-images/mine/2cn5) | |