6NRH
| Crystal Structure of human PARP-1 ART domain bound inhibitor UTT63 | Descriptor: | 3-hydroxy-2-({4-[4-(pyrimidin-2-yl)piperazine-1-carbonyl]phenyl}methyl)-1-benzofuran-7-carboxamide, DIMETHYL SULFOXIDE, Poly [ADP-ribose] polymerase 1, ... | Authors: | Langelier, M.F, Pascal, J.M. | Deposit date: | 2019-01-23 | Release date: | 2019-08-14 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity. J.Med.Chem., 62, 2019
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1OBT
| STRUCTURE OF RICIN A CHAIN MUTANT, COMPLEX WITH AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, RICIN A CHAIN | Authors: | Day, P.J, Ernst, S.R, Frankel, A.E, Monzingo, A.F, Pascal, J.M, Svinth, M, Robertus, J.D. | Deposit date: | 1996-06-22 | Release date: | 1997-06-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure and activity of an active site substitution of ricin A chain. Biochemistry, 35, 1996
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1OBS
| STRUCTURE OF RICIN A CHAIN MUTANT | Descriptor: | RICIN A CHAIN | Authors: | Day, P.J, Ernst, S.R, Frankel, A.E, Monzingo, A.F, Pascal, J.M, Svinth, M, Robertus, J.D. | Deposit date: | 1996-06-25 | Release date: | 1997-06-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure and activity of an active site substitution of ricin A chain. Biochemistry, 35, 1996
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6VKQ
| Crystal Structure of human PARP-1 CAT domain bound to inhibitor EB-47 | Descriptor: | 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Poly [ADP-ribose] polymerase 1, SULFATE ION | Authors: | Steffen, J.D, Pascal, J.M. | Deposit date: | 2020-01-21 | Release date: | 2020-06-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for allosteric PARP-1 retention on DNA breaks. Science, 368, 2020
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6VKK
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6VKO
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7RPX
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7RPO
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7RPW
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