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PDB: 59 件
5KNI
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BU of 5kni by Molmil
Crystal Structure of the wild-type SAM domain of human Tankyrase-1
分子名称: Tankyrase-1
著者Pascal, J.M, McCauley, M, Langelier, M.F, Riccio, A.A.
登録日2016-06-28
公開日2016-08-31
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Tankyrase Sterile alpha Motif Domain Polymerization Is Required for Its Role in Wnt Signaling.
Structure, 24, 2016
6BHV
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BU of 6bhv by Molmil
Human PARP-1 bound to NAD+ analog benzamide adenine dinucleotide (BAD)
分子名称: Poly [ADP-ribose] polymerase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4R,5S)-5-(3-carbamoylphenyl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name)
著者Pascal, J.M, Langelier, M.F.
登録日2017-10-31
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献NAD+analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains.
Nat Commun, 9, 2018
1KEY
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BU of 1key by Molmil
Crystal Structure of Mouse Testis/Brain RNA-binding Protein (TB-RBP)
分子名称: translin
著者Pascal, J.M, Hart, P.J, Hecht, N.B, Robertus, J.D.
登録日2001-11-19
公開日2002-07-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal Structure of TB-RBP, a Novel RNA-binding and Regulating Protein
J.Mol.Biol., 319, 2002
1X9N
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BU of 1x9n by Molmil
Crystal Structure of Human DNA Ligase I bound to 5'-adenylated, nicked DNA
分子名称: 5'-phosphorylated DNA, ADENOSINE MONOPHOSPHATE, DNA ligase I, ...
著者Pascal, J.M, O'Brien, P.J, Tomkinson, A.E, Ellenberger, T.
登録日2004-08-23
公開日2004-11-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Human DNA ligase I completely encircles and partially unwinds nicked DNA.
Nature, 432, 2004
4OQA
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BU of 4oqa by Molmil
Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide
分子名称: (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide, DNA (26-MER), Poly [ADP-ribose] polymerase 1, ...
著者Pascal, J.M, Steffen, J.D.
登録日2014-02-07
公開日2014-07-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.65 Å)
主引用文献Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors.
J.Med.Chem., 57, 2014
4OPX
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BU of 4opx by Molmil
Structure of Human PARP-1 bound to a DNA double strand break in complex with (2R)-5-fluoro-2-methyl-2,3-dihydro-1-benzofuran-7-carboxamide
分子名称: (2R)-5-fluoro-2-methyl-2,3-dihydro-1-benzofuran-7-carboxamide, DNA (26-MER), Poly [ADP-ribose] polymerase 1, ...
著者Pascal, J.M, Steffen, J.D.
登録日2014-02-06
公開日2014-07-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.314 Å)
主引用文献Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors.
J.Med.Chem., 57, 2014
4OQB
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BU of 4oqb by Molmil
Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-{4-[2-(morpholin-4-yl)ethoxy]benzylidene}-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide
分子名称: (2Z)-2-{4-[2-(morpholin-4-yl)ethoxy]benzylidene}-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide, DNA (26-MER), Poly [ADP-ribose] polymerase 1, ...
著者Pascal, J.M, Steffen, J.D.
登録日2014-02-07
公開日2014-07-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.362 Å)
主引用文献Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors.
J.Med.Chem., 57, 2014
1HWN
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BU of 1hwn by Molmil
EBULIN COMPLEXED WITH GALACTOSE, TRIGONAL CRYSTAL FORM
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EBULIN, beta-D-galactopyranose
著者Pascal, J.M, Day, P.J, Monzingo, A.F, Ernst, S.R, Robertus, J.D.
登録日2001-01-09
公開日2001-01-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献2.8-A crystal structure of a nontoxic type-II ribosome-inactivating protein, ebulin l.
Proteins, 43, 2001
1HWO
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EBULIN COMPLEXED WITH LACTOSE, TRIGONAL CRYSTAL FORM
分子名称: EBULIN, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Pascal, J.M, Day, P.J, Monzingo, A.F, Ernst, S.R, Robertus, J.D.
登録日2001-01-09
公開日2001-01-24
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献2.8-A crystal structure of a nontoxic type-II ribosome-inactivating protein, ebulin l.
Proteins, 43, 2001
1HWP
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EBULIN COMPLEXED WITH PTEROIC ACID, TRIGONAL CRYSTAL FORM
分子名称: EBULIN, PTEROIC ACID, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ...
著者Pascal, J.M, Day, P.J, Monzingo, A.F, Ernst, S.R, Robertus, J.D.
登録日2001-01-09
公開日2001-01-24
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献2.8-A crystal structure of a nontoxic type-II ribosome-inactivating protein, ebulin l.
Proteins, 43, 2001
1HWM
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BU of 1hwm by Molmil
EBULIN,ORTHORHOMBIC CRYSTAL FORM MODEL
分子名称: EBULIN, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose
著者Pascal, J.M, Day, P.J, Monzingo, A.F, Ernst, S.R, Robertus, J.D.
登録日2001-01-09
公開日2001-01-24
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献2.8-A crystal structure of a nontoxic type-II ribosome-inactivating protein, ebulin l.
Proteins, 43, 2001
2RIQ
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BU of 2riq by Molmil
Crystal Structure of the Third Zinc-binding domain of human PARP-1
分子名称: ETHANOL, GLYCEROL, Poly [ADP-ribose] polymerase 1, ...
著者Pascal, J.M, Langelier, M.F, Servent, K.M.
登録日2007-10-12
公開日2008-01-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A Third Zinc-binding Domain of Human Poly(ADP-ribose) Polymerase-1 Coordinates DNA-dependent Enzyme Activation.
J.Biol.Chem., 283, 2008
2HIK
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BU of 2hik by Molmil
heterotrimeric PCNA sliding clamp
分子名称: PCNA1 (SSO0397), PCNA2 (SSO1047), PCNA3 (SSO0405)
著者Pascal, J.M, Tsodikov, O.V, Ellenberger, T.
登録日2006-06-29
公開日2006-11-07
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA.
Mol.Cell, 24, 2006
2HII
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BU of 2hii by Molmil
heterotrimeric PCNA sliding clamp
分子名称: PCNA1 (SSO0397), PCNA2 (SSO1047), PCNA3 (SSO0405)
著者Pascal, J.M, Tsodikov, O.V, Ellenberger, T.
登録日2006-06-29
公開日2006-11-07
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA.
Mol.Cell, 24, 2006
2HIV
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BU of 2hiv by Molmil
ATP-dependent DNA ligase from S. solfataricus
分子名称: Thermostable DNA ligase
著者Pascal, J.M, Ellenberger, T.
登録日2006-06-29
公開日2006-11-07
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA.
Mol.Cell, 24, 2006
2HIX
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BU of 2hix by Molmil
ATP dependent DNA ligase from S. solfataricus bound to ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Thermostable DNA ligase
著者Pascal, J.M, Ellenberger, T.
登録日2006-06-29
公開日2006-11-07
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA.
Mol.Cell, 24, 2006
3OD8
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BU of 3od8 by Molmil
Human PARP-1 zinc finger 1 (Zn1) bound to DNA
分子名称: 5'-D(*CP*CP*CP*AP*AP*GP*CP*GP*GP*C)-3', 5'-D(*GP*CP*CP*GP*CP*TP*TP*GP*GP*G)-3', Poly [ADP-ribose] polymerase 1, ...
著者Pascal, J.M, Langelier, M.-F.
登録日2010-08-11
公開日2011-01-12
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY.
J.Biol.Chem., 286, 2011
3ODA
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BU of 3oda by Molmil
Human PARP-1 zinc finger 1 (Zn1) bound to DNA
分子名称: 5'-D(*GP*CP*CP*TP*GP*CP*AP*GP*GP*C)-3', Poly [ADP-ribose] polymerase 1, ZINC ION
著者Pascal, J.M, Langelier, M.-F.
登録日2010-08-11
公開日2011-01-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.64 Å)
主引用文献Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY.
J.Biol.Chem., 286, 2011
3ODE
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BU of 3ode by Molmil
Human PARP-1 zinc finger 2 (Zn2) bound to DNA
分子名称: 5'-D(*CP*CP*CP*AP*AP*GP*CP*G)-3', 5'-D(*CP*GP*CP*TP*TP*GP*GP*G)-3', Poly [ADP-ribose] polymerase 1, ...
著者Pascal, J.M, Langelier, M.-F.
登録日2010-08-11
公開日2011-01-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY.
J.Biol.Chem., 286, 2011
3ODC
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BU of 3odc by Molmil
Human PARP-1 zinc finger 2 (Zn2) bound to DNA
分子名称: 5'-D(*CP*CP*CP*AP*GP*AP*CP*G)-3', 5'-D(*CP*GP*TP*CP*TP*GP*GP*G)-3', Poly [ADP-ribose] polymerase 1, ...
著者Pascal, J.M, Langelier, M.-F.
登録日2010-08-11
公開日2011-01-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY.
J.Biol.Chem., 286, 2011
5JHQ
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BU of 5jhq by Molmil
ARCs 1-3 of human Tankyrase-1 bound to a peptide derived from IRAP
分子名称: Peptide derived from insulin-responsive aminopeptidase (IRAP), Tankyrase-1
著者Eisemann, T, Pascal, J.M.
登録日2016-04-21
公開日2016-09-21
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.
Structure, 24, 2016
8FYZ
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Crystal structure of human PARP1 ART domain bound to inhibitor UKTT10 (compound 13)
分子名称: (2P)-2-{3-[(4R)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carbonyl]phenyl}-1H-benzimidazole-4-carboxamide, CITRIC ACID, DIMETHYL SULFOXIDE, ...
著者Rouleau-Turcotte, E, Pascal, J.M.
登録日2023-01-27
公開日2024-02-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.
Biochem.J., 481, 2024
8FYY
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Crystal structure of human PARP1 ART domain bound to inhibitor UKTT5 (compound 10)
分子名称: 2-(4-{[2-(1H-benzimidazol-2-yl)ethyl]carbamoyl}phenyl)-1H-benzimidazole-7-carboxamide, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
著者Rouleau-Turcotte, E, Pascal, J.M.
登録日2023-01-27
公開日2024-02-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.
Biochem.J., 481, 2024
8G0H
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Human PARP1 deltaV687-E688 bound to UKTT5 (compound 10) and to a DNA double strand break.
分子名称: 2-(4-{[2-(1H-benzimidazol-2-yl)ethyl]carbamoyl}phenyl)-1H-benzimidazole-7-carboxamide, DNA (5'-D(*CP*GP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*CP*G)-3'), ...
著者Rouleau-Turcotte, E, Pascal, J.M.
登録日2023-01-31
公開日2024-02-07
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.
Biochem.J., 481, 2024
8FZ1
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Crystal structure of human PARP1 ART domain bound to inhibitor UKTT22 (compound 14)
分子名称: (2P)-2-{3-[(2-amino-4,5-dimethylphenyl)carbamoyl]phenyl}-1H-benzimidazole-4-carboxamide, 1,2-ETHANEDIOL, CITRIC ACID, ...
著者Rouleau-Turcotte, E, Pascal, J.M.
登録日2023-01-27
公開日2024-02-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.
Biochem.J., 481, 2024

 

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