8DTM
| Cryo-EM structure of insulin receptor (IR) bound with S597 component 2 | Descriptor: | Insulin mimetic peptide S597 component 2, Insulin receptor | Authors: | Park, J, Li, J, Mayer, J.P, Ball, K.A, Wu, J.Y, Hall, C, Accili, D, Stowell, M.H.B, Bai, X.C, Choi, E. | Deposit date: | 2022-07-26 | Release date: | 2022-09-07 | Last modified: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun, 13, 2022
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8DTL
| Cryo-EM structure of insulin receptor (IR) bound with S597 peptide | Descriptor: | Insulin mimetic peptide S597, Insulin receptor | Authors: | Park, J, Li, J, Mayer, J.P, Ball, K.A, Wu, J.Y, Hall, C, Accili, D, Stowell, M.H.B, Bai, X.C, Choi, E. | Deposit date: | 2022-07-25 | Release date: | 2022-09-07 | Last modified: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (5.4 Å) | Cite: | Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun, 13, 2022
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6JCG
| Room temperature structure of HIV-1 Integrase catalytic core domain by serial femtosecond crystallography. | Descriptor: | CACODYLATE ION, Integrase | Authors: | Park, J.H, Shi, Y, Han, J, Li, X, Kim, T.H, Yun, J.H. | Deposit date: | 2019-01-28 | Release date: | 2019-07-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Non-Cryogenic Structure and Dynamics of HIV-1 Integrase Catalytic Core Domain by X-ray Free-Electron Lasers. Int J Mol Sci, 20, 2019
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6JCF
| Cryogenic structure of HIV-1 Integrase catalytic core domain by synchrotron | Descriptor: | CACODYLATE ION, Integrase | Authors: | Park, J.H, Han, J, Kim, T.H, Yun, J.H, Lee, W. | Deposit date: | 2019-01-28 | Release date: | 2019-07-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.153 Å) | Cite: | Non-Cryogenic Structure and Dynamics of HIV-1 Integrase Catalytic Core Domain by X-ray Free-Electron Lasers. Int J Mol Sci, 20, 2019
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4GO6
| Crystal structure of HCF-1 self-association sequence 1 | Descriptor: | HCF C-terminal chain 1, HCF N-terminal chain 1, SULFATE ION | Authors: | Park, J, Lammers, F, Herr, W, Song, J. | Deposit date: | 2012-08-18 | Release date: | 2012-10-17 | Last modified: | 2013-07-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | HCF-1 self-association via an interdigitated Fn3 structure facilitates transcriptional regulatory complex formation Proc.Natl.Acad.Sci.USA, 109, 2012
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8GI1
| Homo-octamer of PbuCsx28 protein | Descriptor: | Accessory protein Csx28 | Authors: | Park, J.U, Kellogg, E.H. | Deposit date: | 2023-03-13 | Release date: | 2023-04-26 | Last modified: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Csx28 is a membrane pore that enhances CRISPR-Cas13b-dependent antiphage defense. Science, 380, 2023
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7FCI
| human NTCP in complex with YN69083 Fab | Descriptor: | Fab Heavy chain, Fab Light chain, Sodium/bile acid cotransporter | Authors: | Park, J.H, Iwamoto, M, Yun, J.H, Uchikubo-Kamo, T, Son, D, Jin, Z, Yoshida, H, Ohki, M, Ishimoto, N, Mizutani, K, Oshima, M, Muramatsu, M, Wakita, T, Shirouzu, M, Liu, K, Uemura, T, Nomura, N, Iwata, S, Watashi, K, Tame, J.R.H, Nishizawa, T, Lee, W, Park, S.Y. | Deposit date: | 2021-07-14 | Release date: | 2022-05-25 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural insights into the HBV receptor and bile acid transporter NTCP. Nature, 606, 2022
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7U5D
| I-F3b Cascade-TniQ full R-loop complex | Descriptor: | Cas6, Cas7, Cas8/5, ... | Authors: | Park, J.U, Mehrotra, E, Kellogg, E.H. | Deposit date: | 2022-03-02 | Release date: | 2023-06-21 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Multiple adaptations underly co-option of a CRISPR surveillance complex for RNA-guided DNA transposition. Mol.Cell, 83, 2023
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7M9A
| ADP-AlF3 bound TnsC structure from ShCAST system | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (27-MER), TnsC | Authors: | Park, J, Tsai, A.W.L, Mehrotra, E, Kellogg, E.H. | Deposit date: | 2021-03-30 | Release date: | 2021-07-28 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis for target site selection in RNA-guided DNA transposition systems. Science, 373, 2021
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7M9C
| ADP-AlF3 bound TnsC structure in open form | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (34-MER), TnsC | Authors: | Park, J, Tsai, A.W.L, Mehrotra, E, Kellogg, E.H. | Deposit date: | 2021-03-30 | Release date: | 2021-07-28 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis for target site selection in RNA-guided DNA transposition systems. Science, 373, 2021
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7M9B
| ADP-AlF3 bound TnsC structure in closed form | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (27-MER), TnsC | Authors: | Park, J, Tsai, A.W.L, Mehrotra, E, Kellogg, E.H. | Deposit date: | 2021-03-30 | Release date: | 2021-07-28 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis for target site selection in RNA-guided DNA transposition systems. Science, 373, 2021
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6N82
| Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Farnesyl pyrophosphate synthase, ... | Authors: | Park, J, Schilling, M.A, Berghuis, A.M. | Deposit date: | 2018-11-28 | Release date: | 2019-11-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS). J.Med.Chem., 62, 2019
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7N6I
| ATP-bound TnsC-TniQ complex from ShCAST system | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ... | Authors: | Park, J, Tsai, A.W.L, Mehrotra, E, Kellogg, E.H. | Deposit date: | 2021-06-08 | Release date: | 2021-07-28 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis for target site selection in RNA-guided DNA transposition systems. Science, 373, 2021
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7U5E
| I-F3b Cascade-TniQ partial R-loop complex | Descriptor: | Cas6, Cas7, Cas8/5, ... | Authors: | Park, J.U, Mehrotra, E, Kellogg, E.H. | Deposit date: | 2022-03-02 | Release date: | 2023-06-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.03 Å) | Cite: | Multiple adaptations underly co-option of a CRISPR surveillance complex for RNA-guided DNA transposition. Mol.Cell, 83, 2023
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4ID4
| Crystal structure of chimeric beta-lactamase cTEM-17m | Descriptor: | Beta-lactamase TEM, Beta-lactamase PSE-4, CHLORIDE ION, ... | Authors: | Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M. | Deposit date: | 2012-12-11 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Maintenance of Native-like Protein Dynamics May Not Be Required for Engineering Functional Proteins. Chem.Biol., 21, 2014
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6IQ6
| Crystal structure of GAPDH | Descriptor: | (2Z)-4-methoxy-4-oxobut-2-enoic acid, Glyceraldehyde-3-phosphate dehydrogenase | Authors: | Park, J.B, Park, H.Y. | Deposit date: | 2018-11-06 | Release date: | 2019-08-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Structural Study of Monomethyl Fumarate-Bound Human GAPDH. Mol.Cells, 42, 2019
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4DEM
| Crystal structure of human FPPS in complex with YS_04_70 | Descriptor: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid) | Authors: | Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. | Deposit date: | 2012-01-20 | Release date: | 2012-03-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells. J.Med.Chem., 55, 2012
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4H5E
| Crystal structure of human FPPS in ternary complex with YS0470 and isopentenyl pyrophosphate | Descriptor: | Farnesyl pyrophosphate synthase, ISOPENTYL PYROPHOSPHATE, MAGNESIUM ION, ... | Authors: | Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. | Deposit date: | 2012-09-18 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. Bmc Struct.Biol., 12, 2012
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4H5D
| Crystal structure of human FPPS in ternary complex with YS0470 and inorganic pyrophosphate | Descriptor: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | Authors: | Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. | Deposit date: | 2012-09-18 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. Bmc Struct.Biol., 12, 2012
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4HJO
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4H5C
| Crystal structure of human FPPS in ternary complex with YS0470 and inorganic phosphate | Descriptor: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. | Deposit date: | 2012-09-18 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. Bmc Struct.Biol., 12, 2012
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6N9H
| De novo designed homo-trimeric amantadine-binding protein | Descriptor: | (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine, SODIUM ION, amantadine-binding protein | Authors: | Park, J, Baker, D. | Deposit date: | 2018-12-03 | Release date: | 2019-12-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.039 Å) | Cite: | De novo design of a homo-trimeric amantadine-binding protein. Elife, 8, 2019
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6N7Y
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6N7Z
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6N83
| Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037 | Descriptor: | CHLORIDE ION, Farnesyl pyrophosphate synthase, PHOSPHATE ION, ... | Authors: | Park, J, Schilling, M.A, Berghuis, A.M. | Deposit date: | 2018-11-28 | Release date: | 2019-11-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS). J.Med.Chem., 62, 2019
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