6CBY
 
 | | Crystal structure of human SET and MYND Domain Containing protein 2 with MTF9975 | | 分子名称: | N-lysine methyltransferase SMYD2, ZINC ION, [3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)-3-methylazetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone | | 著者 | ZENG, H, DONG, A, Hutchinson, A, Seitova, A, TATLOCK, J, KUMPF, R, OWEN, A, TAYLOR, A, Casimiro-Garcia, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | | 登録日 | 2018-02-05 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase.
J.Med.Chem., 62, 2019
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1NZ6
 | | Crystal Structure of Auxilin J-Domain | | 分子名称: | Auxilin | | 著者 | Jiang, J, Taylor, A.B, Prasad, K, Ishikawa-Brush, Y, Hart, P.J, Lafer, E.M, Sousa, R. | | 登録日 | 2003-02-16 | | 公開日 | 2003-04-22 | | 最終更新日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure-function analysis of the auxilin J-domain reveals an extended Hsc70 interaction interface.
Biochemistry, 42, 2003
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1MR0
 | | SOLUTION NMR STRUCTURE OF AGRP(87-120; C105A) | | 分子名称: | AGOUTI RELATED PROTEIN | | 著者 | Jackson, P.J, Mcnulty, J.C, Yang, Y.K, Thompson, D.A, Chai, B, Gantz, I, Barsh, G.S, Millhauser, G.M. | | 登録日 | 2002-09-17 | | 公開日 | 2002-10-02 | | 最終更新日 | 2021-10-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity.
Biochemistry, 41, 2002
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1DLP
 | | STRUCTURAL CHARACTERIZATION OF THE NATIVE FETUIN-BINDING PROTEIN SCILLA CAMPANULATA AGGLUTININ (SCAFET): A NOVEL TWO-DOMAIN LECTIN | | 分子名称: | LECTIN SCAFET PRECURSOR | | 著者 | Wright, L.M, Reynolds, C.D, Rizkallah, P.J, Allen, A.K, VanDamme, E.J.M, Donovan, M.J, Peumans, W.J. | | 登録日 | 1999-12-11 | | 公開日 | 2000-02-10 | | 最終更新日 | 2017-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structural characterisation of the native fetuin-binding protein Scilla campanulata agglutinin: a novel two-domain lectin.
FEBS Lett., 468, 2000
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1MXO
 | | AmpC beta-lactamase in complex with an m.carboxyphenylglycylboronic acid bearing the cephalothin R1 side chain | | 分子名称: | (1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID, Beta-lactamase, PHOSPHATE ION | | 著者 | Morandi, F, Caselli, E, Morandi, S, Focia, P.J, Blazquez, J, Shoichet, B.K, Prati, F. | | 登録日 | 2002-10-02 | | 公開日 | 2003-03-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Nanomolar inhibitors of AmpC beta-lactamase.
J.Am.Chem.Soc., 125, 2003
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1MY8
 | | AmpC beta-lactamase in complex with an M.carboxyphenylglycylboronic acid bearing the cephalothin R1 side chain | | 分子名称: | (1R)-1-(2-THIENYLACETYLAMINO)-1-PHENYLMETHYLBORONIC ACID, PHOSPHATE ION, beta-lactamase | | 著者 | Morandi, F, Caselli, E, Morandi, S, Focia, P.J, Blazquez, J, Shoichet, B.K, Prati, F. | | 登録日 | 2002-10-03 | | 公開日 | 2003-03-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Nanomolar inhibitors of AmpC beta-lactamase.
J.Am.Chem.Soc., 125, 2003
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6V53
 | | The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000985494 | | 分子名称: | Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, Polymerase acidic protein, ... | | 著者 | Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. | | 登録日 | 2019-12-03 | | 公開日 | 2020-12-09 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000985494
To Be Published
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6FJO
 | | Adenovirus species 26 knob protein, very high resolution | | 分子名称: | Fiber, GLUTAMIC ACID, GLYCEROL, ... | | 著者 | Rizkallah, P.J, Parker, A.L, Baker, A.T. | | 登録日 | 2018-01-22 | | 公開日 | 2019-02-06 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | | 主引用文献 | Human adenovirus type 26 uses sialic acid-bearing glycans as a primary cell entry receptor.
Sci Adv, 5, 2019
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2N2Q
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1MFV
 | | Probing the role of a mobile loop in human slaivary amylase: Structural studies on the loop-deleted enzyme | | 分子名称: | 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose, 5-HYDROXYMETHYL-CHONDURITOL, ... | | 著者 | Ramasubbu, N, Ragunath, C, Mishra, P.J. | | 登録日 | 2002-08-13 | | 公開日 | 2002-11-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Probing the role of a mobile loop in substrate binding and enzyme activity of
human salivary amylase.
J.Mol.Biol., 325, 2003
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1MFP
 | | E. coli Enoyl Reductase in complex with NAD and SB611113 | | 分子名称: | (E)-N-METHYL-N-(1-METHYL-1H-INDOL-3-YLMETHYL)-3-(7-OXO-5,6,7,8-TETRAHYDRO-[1,8]NAPHTHYRIDIN-3-YL)-ACRYLAMIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ... | | 著者 | Seefeld, M.A, Miller, W.H, Newlander, K.A, Burgess, W.J, DeWolf Jr, W.E, Elkins, P.A, Head, M.S, Jakas, D.R, Janson, C.A, Keller, P.M, Manley, P.J, Moore, T.D, Payne, D.J, Pearson, S, Polizzi, B.J, Qiu, X, Rittenhouse, S.F, Uzinskas, I.N, Wallis, N.G, Huffman, W.F. | | 登録日 | 2002-08-13 | | 公開日 | 2003-05-06 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK
J.MED.CHEM., 46, 2003
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6CH9
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6BYB
 | | Crystal structure of L3MBTL1 MBT Domain with MBK14970 | | 分子名称: | (S)-N-(cyclopropylmethyl)-N~2~-methyl-N-[2-methyl-2-(1-methylpiperidin-4-yl)propyl]alaninamide, 1,2-ETHANEDIOL, Lethal(3)malignant brain tumor-like protein 1, ... | | 著者 | DONG, A, DOBROVETSKY, E, NICHOLSON, B, COX, C, FISCHER, C, ARMACOST, K, SANDERS, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, Structural Genomics Consortium (SGC) | | 登録日 | 2017-12-20 | | 公開日 | 2018-01-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Crystal structure of L3MBTL1 MBT Domain with MBK14970
to be published
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1LZH
 | | THE STRUCTURES OF THE MONOCLINIC AND ORTHORHOMBIC FORMS OF HEN EGG-WHITE LYSOZYME AT 6 ANGSTROMS RESOLUTION. | | 分子名称: | HEN EGG WHITE LYSOZYME | | 著者 | Artymiuk, P.J, Blake, C.C.F, Rice, D.W, Wilson, K.S. | | 登録日 | 1981-06-29 | | 公開日 | 1981-09-28 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (6 Å) | | 主引用文献 | The Structures of the Monoclinic and Orthorhombic Forms of Hen Egg-White Lysozyme at 6 Angstroms Resolution.
Acta Crystallogr.,Sect.B, 38, 1982
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2NQA
 | | Catalytic Domain of Human Calpain 8 | | 分子名称: | CALCIUM ION, Calpain-8, Leupeptin Inhibitor | | 著者 | Davis, T.L, Paramanathan, R, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | 登録日 | 2006-10-30 | | 公開日 | 2006-11-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of Human Calpain 8
To be Published
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1OA3
 | | Comparison of Family 12 Glycoside Hydrolases and Recruited Substitutions Important for Thermal Stability | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ENDO-BETA-1-4-GLUCANASE | | 著者 | Sandgren, M, Gualfetti, P.J, Shaw, A, Gross, L.S, Saldajeno, M, Day, A.G, Jones, T.A, Mitchinson, C. | | 登録日 | 2002-12-28 | | 公開日 | 2003-03-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Comparison of Family 12 Glycoside Hydrolases and Recruited Substitutions Important for Thermal Stability
Protein Sci., 12, 2003
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2NC9
 | | Apo solution structure of Hop TPR2A | | 分子名称: | Stress-induced-phosphoprotein 1 | | 著者 | Darby, J.F, Vidler, L.R, Simpson, P.J, Matthews, S.J, Sharp, S.Y, Pearl, L.H, Hoelder, S, Workman, P. | | 登録日 | 2016-03-23 | | 公開日 | 2017-03-29 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches.
Sci Rep, 10, 2020
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1OC1
 | | ISOPENICILLIN N SYNTHASE aminoadipoyl-cysteinyl-aminobutyrate-FE COMPLEX | | 分子名称: | DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VINYLGLYCINE, FE (II) ION, ISOPENICILLIN N SYNTHETASE, ... | | 著者 | Long, A.J, Clifton, I.J, Roach, P.L, Baldwin, J.E, Schofield, C.J, Rutledge, P.J. | | 登録日 | 2003-02-03 | | 公開日 | 2004-02-02 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Studies on the Reaction of Isopenicillin N Synthase with the Substrate Analogue Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-D-Alpha-Aminobutyrate
Biochem.J., 372, 2003
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6CBX
 | | Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, N-lysine methyltransferase SMYD2, ... | | 著者 | ZENG, H, DONG, A, Hutchinson, A, Seitova, A, TATLOCK, J, KUMPF, R, OWEN, A, TAYLOR, A, Casimiro-Garcia, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | | 登録日 | 2018-02-05 | | 公開日 | 2018-03-14 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497
to be published
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6CG3
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6CG5
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1NVS
 | | The Complex Structure Of Checkpoint Kinase Chk1/SB218078 | | 分子名称: | Peptide ASVSA, REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONE, SULFATE ION, ... | | 著者 | Zhao, B, Bower, M.J, McDevitt, P.J, Zhao, H, Davis, S.T, Johanson, K.O, Green, S.M, Concha, N.O, Zhou, B.B. | | 登録日 | 2003-02-04 | | 公開日 | 2003-04-08 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Basis for Chk1 Inhibition by UCN-01
J.Biol.Chem., 277, 2002
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6CH8
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1N4Q
 | | Protein Geranylgeranyltransferase type-I Complexed with a GGPP Analog and a KKKSKTKCVIL Peptide | | 分子名称: | 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE, CHLORIDE ION, Fusion protein consisting of transforming protein p21b and Ras related protein Rap-2b, ... | | 著者 | Taylor, J.S, Reid, T.S, Casey, P.J, Beese, L.S. | | 登録日 | 2002-11-01 | | 公開日 | 2003-11-18 | | 最終更新日 | 2017-06-28 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of mammalian protein geranylgeranyltransferase type-I
EMBO J., 22, 2003
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1N4S
 | | Protein Geranylgeranyltransferase type-I Complexed with GGPP and a Geranylgeranylated KKKSKTKCVIL Peptide Product | | 分子名称: | CHLORIDE ION, Fusion protein consisting of transforming protein p21b and Ras related protein Rap-2b, GERAN-8-YL GERAN, ... | | 著者 | Taylor, J.S, Reid, T.S, Casey, P.J, Beese, L.S. | | 登録日 | 2002-11-01 | | 公開日 | 2003-11-18 | | 最終更新日 | 2017-06-28 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of mammalian protein geranylgeranyltransferase type-I
EMBO J., 22, 2003
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