6SWC
| IC2B model of cryo-EM structure of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi | Descriptor: | 16S ribosomal rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Coureux, P.-D, Mechulam, Y, Schmitt, E. | Deposit date: | 2019-09-20 | Release date: | 2020-02-19 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation. Commun Biol, 3, 2020
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8OUW
| Cryo-EM structure of CMG helicase bound to TIM-1/TIPN-1 and homodimeric DNSN-1 on fork DNA (Caenorhabditis elegans) | Descriptor: | Cell division control protein 45 homolog, DNA Lagging Strand Template, DNA Leading Strand Template, ... | Authors: | Jenkyn-Bedford, M, Yeeles, J.T.P, Labib, K.P.M. | Deposit date: | 2023-04-25 | Release date: | 2023-08-16 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans. Science, 381, 2023
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5X6D
| Crystal structure of PrfA-DNA binary complex | Descriptor: | DNA (28-MER), DNA (29-MER), Listeriolysin positive regulatory factor A | Authors: | Wang, Y, Feng, H, Zhu, Y.L, Gao, P. | Deposit date: | 2017-02-21 | Release date: | 2017-04-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Structural insights into glutathione-mediated activation of the master regulator PrfA in Listeria monocytogenes Protein Cell, 8, 2017
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7NBU
| Structure of the HigB1 toxin mutant K95A from Mycobacterium tuberculosis (Rv1955) and its target, the cspA mRNA, on the E. coli Ribosome. | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Giudice, E, Mansour, M, Chat, S, D'Urso, G, Gillet, R, Genevaux, P. | Deposit date: | 2021-01-27 | Release date: | 2022-03-02 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis. Nat Commun, 13, 2022
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5FT9
| Arabidopsis thaliana nuclear protein-only RNase P 2 (PRORP2) | Descriptor: | PROTEINACEOUS RNASE P 2, ZINC ION | Authors: | Fernandez-Millan, P, Pinker, F, Schelcher, C, Gobert, A, Giege, P, Sauter, C. | Deposit date: | 2016-01-12 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Structures of Arabidopsis Nuclear Rnase P Alone and with tRNA Reveal Plasticities To be Published
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6N4C
| EM structure of the DNA wrapping in bacterial open transcription initiation complex | Descriptor: | DNA (94-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Florez-Ariza, A, Cassago, A, de Oliveira, P.S.L, Guerra, D.G, Portugal, R.V. | Deposit date: | 2018-11-19 | Release date: | 2020-05-27 | Method: | ELECTRON MICROSCOPY (17 Å) | Cite: | Interactions of Upstream and Downstream Promoter Regions with RNA Polymerase are Energetically Coupled and a Target of Regulation in Transcription Initiation Biorxiv, 2020
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6MK1
| Cryo-EM of self-assembly peptide filament HEAT_R1 | Descriptor: | peptide HEAT_R1 | Authors: | Wang, F, Hughes, S.A, Orlova, A, Conticello, V.P, Egelman, E.H. | Deposit date: | 2018-09-24 | Release date: | 2019-06-26 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs. Proc.Natl.Acad.Sci.USA, 116, 2019
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6YEN
| Crystal structure of AmpC from E. coli with Taniborbactam (VNRX-5133) | Descriptor: | (10aR)-2-(((1r,4R)-4-((2-aminoethyl)amino)cyclohexyl)methyl)-6-carboxy-4-hydroxy-4,10a-dihydro-10H-benzo[5,6][1,2]oxaborinino[2,3-b][1,4,2]oxazaborol-4-uide, (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, 1,2-ETHANEDIOL, ... | Authors: | Lang, P.A, Brem, J, Schofield, C.J. | Deposit date: | 2020-03-25 | Release date: | 2020-06-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.418 Å) | Cite: | Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C beta-Lactamase from Escherichia coli . Biomolecules, 10, 2020
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6YHN
| Crystal structure of domains 4-5 of CNFy from Yersinia pseudotuberculosis | Descriptor: | (R,R)-2,3-BUTANEDIOL, CHLORIDE ION, Cytotoxic necrotizing factor, ... | Authors: | Lukat, P, Gazdag, E.M, Heidler, T.V, Blankenfeldt, W. | Deposit date: | 2020-03-30 | Release date: | 2020-12-30 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of bacterial cytotoxic necrotizing factor CNF Y reveals molecular building blocks for intoxication. Embo J., 40, 2021
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6G4Z
| Crystal structure of murine NF-kappaB inducing kinase (NIK) in complex with compound 2f | Descriptor: | 5-fluoranyl-1-[4-[2-[(3~{R})-1-methyl-3-oxidanyl-2-oxidanylidene-pyrrol-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamide, Mitogen-activated protein kinase kinase kinase 14 | Authors: | Leonardo-Silvestre, H, McEwan, P.A, Hymowitz, S.G. | Deposit date: | 2018-03-28 | Release date: | 2018-07-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase. J. Med. Chem., 61, 2018
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6MQB
| Crystal Structure of GTPase Domain of Human Septin 12 in complex with GMPPNP in Space Group C2221 | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Septin-12 | Authors: | Castro, D.K.S.V, Pereira, H.M, Brandao-Neto, J, Ulian, A.P.U, Garratt, R.C. | Deposit date: | 2018-10-09 | Release date: | 2019-10-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | A complete compendium of crystal structures for the human SEPT3 subgroup reveals functional plasticity at a specific septin interface. Iucrj, 7, 2020
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6MO6
| Crystal structure of the selenomethionine-substituted human sulfide:quinone oxidoreductase | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Sulfide:quinone oxidoreductase, ... | Authors: | Jackson, M.R, Jorns, M.S, Loll, P.J. | Deposit date: | 2018-10-04 | Release date: | 2019-04-10 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | X-Ray Structure of Human Sulfide:Quinone Oxidoreductase: Insights into the Mechanism of Mitochondrial Hydrogen Sulfide Oxidation. Structure, 27, 2019
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3BOY
| Crystal structure of the HutP antitermination complex bound to the HUT mRNA | Descriptor: | 5'-R(*UP*UP*UP*AP*GP*UP*UP*UP*UP*UP*AP*GP*UP*UP*UP*UP*UP*AP*GP*UP*UP*U)-3', HISTIDINE, Hut operon positive regulatory protein, ... | Authors: | Kumarevel, T.S, Balasundaresan, D, Jeyakanthan, J, Shinkai, A, Yokoyama, S, Kumar, P.K.R, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-12-18 | Release date: | 2008-01-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure of HutP complexed with the 55-mer RNA To be Published
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7Q5N
| Crystal structure of Chaetomium thermophilum Ahp1-Urm1 complex | Descriptor: | Thioredoxin domain-containing protein, Ubiquitin-related modifier 1, ZINC ION | Authors: | Ravichandran, K.E, Wilk, P, Grudnik, P, Glatt, S. | Deposit date: | 2021-11-04 | Release date: | 2022-08-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation. Embo J., 41, 2022
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7SXM
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6FO2
| CryoEM structure of bovine cytochrome bc1 with no ligand bound | Descriptor: | Cytochrome b, Cytochrome b-c1 complex subunit 1, mitochondrial, ... | Authors: | Johnson, R.M, Amporndanai, K, O'Neill, P.M, Fishwick, C.W.G, Jamson, A.H, Rawson, S.D, Hasnain, S.S, Antonyuk, S.V, Muench, S.P. | Deposit date: | 2018-02-05 | Release date: | 2018-02-28 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | X-ray and cryo-EM structures of inhibitor-bound cytochromebc1complexes for structure-based drug discovery. IUCrJ, 5, 2018
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3C2I
| The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF | Descriptor: | DNA (5'-D(*DAP*DTP*DAP*DGP*DAP*DAP*DGP*DAP*DAP*DTP*DTP*DCP*(5CM)P*DGP*DTP*DTP*DCP*DCP*DAP*DG)-3'), DNA (5'-D(*DTP*DCP*DTP*DGP*DGP*DAP*DAP*(5CM)P*DGP*DGP*DAP*DAP*DTP*DTP*DCP*DTP*DTP*DCP*DTP*DA)-3'), Methyl-CpG-binding protein 2 | Authors: | Ho, K.L, McNae, I.W, Schmiedeberg, L, Klose, R.J, Bird, A.P, Walkinshaw, M.D. | Deposit date: | 2008-01-25 | Release date: | 2008-05-13 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | MeCP2 binding to DNA depends upon hydration at methyl-CpG Mol.Cell, 29, 2008
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7PDV
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6N0X
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7Q68
| Crystal structure of Chaetomium thermophilum wild-type Ahp1 | Descriptor: | GLYCEROL, SULFATE ION, Thioredoxin domain-containing protein | Authors: | Ravichandran, K.E, Wilk, P, Grudnik, P, Glatt, S. | Deposit date: | 2021-11-05 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation. Embo J., 41, 2022
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4RBY
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6N4G
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6YQ6
| Promiscuous Reductase LugOII Catalyzes Keto-reduction at C1 during Lugdunomycin Biosynthesis | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Monooxygenase, ... | Authors: | Xiao, X, Elsayed, S.S, Wu, C, van der Heul, H, Prota, A, Huang, J, Guo, R, Abrahams, J.P, van Wezel, G.P. | Deposit date: | 2020-04-16 | Release date: | 2020-09-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway. Acs Chem.Biol., 15, 2020
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8PJB
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6Y1G
| Photoconverted HcRed in its optoacoustic state | Descriptor: | 1,2-ETHANEDIOL, GFP-like non-fluorescent chromoprotein | Authors: | Janowski, R, Fuenzalida-Werner, J.P, Mishra, K, Stiel, A.C, Niessing, D. | Deposit date: | 2020-02-12 | Release date: | 2020-07-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Challenging a Preconception: Optoacoustic Spectrum Differs from the Optical Absorption Spectrum of Proteins and Dyes for Molecular Imaging. Anal.Chem., 92, 2020
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