3KR8
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![BU of 3kr8 by Molmil](/molmil-images/mine/3kr8) | Human tankyrase 2 - catalytic PARP domain in complex with an inhibitor XAV939 | 分子名称: | 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, GLYCEROL, SULFATE ION, ... | 著者 | Karlberg, T, Schutz, P, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kotenyova, T, Kotzsch, A, Kraulis, P, Nielsen, T.K, Moche, M, Nordlund, P, Nyman, T, Persson, C, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC) | 登録日 | 2009-11-18 | 公開日 | 2009-12-15 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor. J.Med.Chem., 53, 2010
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4CFF
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![BU of 4cff by Molmil](/molmil-images/mine/4cff) | Structure of full length human AMPK in complex with a small molecule activator, a thienopyridone derivative (A-769662) | 分子名称: | 3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7H-thieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1, ... | 著者 | Xiao, B, Sanders, M.J, Carmena, D, Bright, N.J, Haire, L.F, Underwood, E, Patel, B.R, Heath, R.B, Walker, P.A, Hallen, S, Giordanetto, F, Martin, S.R, Carling, D, Gamblin, S.J. | 登録日 | 2013-11-14 | 公開日 | 2013-12-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.924 Å) | 主引用文献 | Structural Basis of Ampk Regulation by Small Molecule Activators. Nat.Commun., 4, 2013
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3U72
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![BU of 3u72 by Molmil](/molmil-images/mine/3u72) | Crystal Structure of C-lobe of Bovine lactoferrin Complexed with Isoniazid at 2.2 A Resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(DIAZENYLCARBONYL)PYRIDINE, ... | 著者 | Shukla, P.K, Gautam, L, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | 登録日 | 2011-10-13 | 公開日 | 2011-11-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of C-lobe of Bovine lactoferrin Complexed with Isoniazid at 2.2 A Resolution To be Published
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4NO1
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![BU of 4no1 by Molmil](/molmil-images/mine/4no1) | yCP in complex with Z-Leu-Leu-Leu-B(OH)2 | 分子名称: | MAGNESIUM ION, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-L-leucinamide, Probable proteasome subunit alpha type-7, ... | 著者 | Stein, M.L, Cui, H, Beck, P, Dubiella, C, Voss, C, Krueger, A, Schmidt, B, Groll, M. | 登録日 | 2013-11-19 | 公開日 | 2014-02-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif. Angew.Chem.Int.Ed.Engl., 53, 2014
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2XVT
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![BU of 2xvt by Molmil](/molmil-images/mine/2xvt) | Structure of the extracellular domain of human RAMP2 | 分子名称: | CALCIUM ION, RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 | 著者 | Quigley, A, Pike, A.C.W, Burgess-Brown, N, Krojer, T, Shrestha, L, Goubin, S, Kim, J, Das, S, Muniz, J.R.C, Canning, P, Chaikuad, A, Vollmar, M, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bountra, C, Barr, A.J, Carpenter, E.P. | 登録日 | 2010-10-31 | 公開日 | 2010-12-29 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure of the Extracellular Domain of Human Ramp2 To be Published
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7YEZ
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![BU of 7yez by Molmil](/molmil-images/mine/7yez) | In situ structure of polymerase complex of mammalian reovirus in the reloaded state | 分子名称: | Lambda-2 protein, Mu-2 protein, RNA helicase, ... | 著者 | Bao, K.Y, Zhang, X.L, Li, D.Y, Zhu, P. | 登録日 | 2022-07-06 | 公開日 | 2023-03-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XR9
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![BU of 7xr9 by Molmil](/molmil-images/mine/7xr9) | Crystal structure of DgpA with glucose | 分子名称: | DgpA, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, beta-D-glucopyranose | 著者 | Ma, W, He, P. | 登録日 | 2022-05-09 | 公開日 | 2023-04-05 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C -glycoside cleaving enzyme and an O - to C -glycoside isomerase. Acta Pharm Sin B, 13, 2023
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4BS2
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![BU of 4bs2 by Molmil](/molmil-images/mine/4bs2) | NMR structure of human TDP-43 tandem RRMs in complex with UG-rich RNA | 分子名称: | 5'-R(*GP*UP*GP*UP*GP*AP*AP*UP*GP*AP*AP*UP)-3', TAR DNA-BINDING PROTEIN 43 | 著者 | Lukavsky, P.J, Daujotyte, D, Tollervey, J.R, Ule, J, Stuani, C, Buratti, E, Baralle, F.E, Damberger, F.F, Allain, F.H.T. | 登録日 | 2013-06-06 | 公開日 | 2013-11-13 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Molecular Basis of Ug-Rich RNA Recognition by the Human Splicing Factor Tdp-43 Nat.Struct.Mol.Biol., 20, 2013
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5DS2
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![BU of 5ds2 by Molmil](/molmil-images/mine/5ds2) | Core domain of the class I small heat-shock protein HSP 18.1 from Pisum sativum | 分子名称: | 18.1 kDa class I heat shock protein, SULFATE ION | 著者 | Shepherd, D.A, Laganowsky, A, Allison, T.M, Hochberg, G.K.A, Benesch, J.L.P. | 登録日 | 2015-09-16 | 公開日 | 2016-09-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions. Science, 359, 2018
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7YF0
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![BU of 7yf0 by Molmil](/molmil-images/mine/7yf0) | In situ structure of polymerase complex of mammalian reovirus in the core | 分子名称: | Lambda-2 protein, Mu-2 protein, RNA helicase, ... | 著者 | Bao, K.Y, Zhang, X.L, Li, D.Y, Zhu, P. | 登録日 | 2022-07-07 | 公開日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation. Proc.Natl.Acad.Sci.USA, 119, 2022
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2XUO
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![BU of 2xuo by Molmil](/molmil-images/mine/2xuo) | CRYSTAL STRUCTURE OF MACHE-Y337A mutant in complex with soaked TZ2PA6 ANTI inhibitor | 分子名称: | 3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-4-YL]HEXYL]-PHENANTHRIDINIUM, ACETYLCHOLINESTERASE, HEXAETHYLENE GLYCOL | 著者 | Bourne, Y, Radic, Z, Taylor, P, Marchot, P. | 登録日 | 2010-10-19 | 公開日 | 2010-12-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Conformational Remodeling of Femtomolar Inhibitor-Acetylcholinesterase Complexes in the Crystalline State J.Am.Chem.Soc., 132, 2010
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2Q5Z
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![BU of 2q5z by Molmil](/molmil-images/mine/2q5z) | Crystal structure of iMazG from Vibrio DAT 722: Ntag-iMazG (P43212) | 分子名称: | GLYCEROL, Hypothetical protein, MAGNESIUM ION | 著者 | Robinson, A, Guilfoyle, A.P, Harrop, S.J, Boucher, Y, Stokes, H.W, Curmi, P.M.G, Mabbutt, B.C. | 登録日 | 2007-06-04 | 公開日 | 2007-10-09 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A putative house-cleaning enzyme encoded within an integron array: 1.8 A crystal structure defines a new MazG subtype. Mol.Microbiol., 66, 2007
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7YEV
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![BU of 7yev by Molmil](/molmil-images/mine/7yev) | In situ structure of polymerase complex of mammalian reovirus in the pre-elongation state | 分子名称: | Lambda-2 protein, Mu-2 protein, RNA helicase, ... | 著者 | Bao, K.Y, Zhang, X.L, Li, D.Y, Zhu, P. | 登録日 | 2022-07-06 | 公開日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation. Proc.Natl.Acad.Sci.USA, 119, 2022
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7H6K
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![BU of 7h6k by Molmil](/molmil-images/mine/7h6k) | Group deposition for crystallographic fragment screening of Chikungunya virus nsP3 macrodomain -- Crystal structure of Chikungunya virus nsP3 macrodomain in complex with Z1041785508 (CHIKV_MacB-x0281) | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-(1,3-thiazol-2-yl)-1H-1,2,4-triazole, CHLORIDE ION, ... | 著者 | Aschenbrenner, J.C, Fairhead, M, Godoy, A.S, Balcomb, B.H, Capkin, E, Chandran, A.V, Dolci, I, Golding, M, Koekemoer, L, Lithgo, R.M, Marples, P.G, Ni, X, Oliva, G, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Xavier, M.-A.E, Fearon, D, von Delft, F. | 登録日 | 2024-04-26 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Group deposition for crystallographic fragment screening of Chikungunya virus nsP3 macrodomain To Be Published
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2XUD
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![BU of 2xud by Molmil](/molmil-images/mine/2xud) | Crystal structure of the Y337A mutant of mouse acetylcholinesterase | 分子名称: | ACETATE ION, ACETYLCHOLINESTERASE, DECAMETHONIUM ION, ... | 著者 | Bourne, Y, Radic, Z, Taylor, P, Marchot, P. | 登録日 | 2010-10-19 | 公開日 | 2010-12-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Conformational Remodeling of Femtomolar Inhibitor-Acetylcholinesterase Complexes in the Crystalline State J.Am.Chem.Soc., 132, 2010
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7H6U
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![BU of 7h6u by Molmil](/molmil-images/mine/7h6u) | Group deposition for crystallographic fragment screening of Chikungunya virus nsP3 macrodomain -- Crystal structure of Chikungunya virus nsP3 macrodomain in complex with Z1216833237 (CHIKV_MacB-x0353) | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Aschenbrenner, J.C, Fairhead, M, Godoy, A.S, Balcomb, B.H, Capkin, E, Chandran, A.V, Dolci, I, Golding, M, Koekemoer, L, Lithgo, R.M, Marples, P.G, Ni, X, Oliva, G, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Xavier, M.-A.E, Fearon, D, von Delft, F. | 登録日 | 2024-04-26 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Group deposition for crystallographic fragment screening of Chikungunya virus nsP3 macrodomain To Be Published
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2XUH
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![BU of 2xuh by Molmil](/molmil-images/mine/2xuh) | CRYSTAL STRUCTURE OF MACHE-Y337A-TZ2PA6 ANTI COMPLEX (10 MTH) | 分子名称: | 3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-4-YL]HEXYL]-PHENANTHRIDINIUM, ACETYLCHOLINESTERASE | 著者 | Bourne, Y, Radic, Z, Taylor, P, Marchot, P. | 登録日 | 2010-10-19 | 公開日 | 2010-12-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Conformational Remodeling of Femtomolar Inhibitor-Acetylcholinesterase Complexes in the Crystalline State J.Am.Chem.Soc., 132, 2010
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2XUQ
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![BU of 2xuq by Molmil](/molmil-images/mine/2xuq) | CRYSTAL STRUCTURE OF the MACHE-Y337A mutant in complex with soaked TZ2PA6 ANTI-SYN inhibitors | 分子名称: | 3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-4-YL]HEXYL]-PHENANTHRIDINIUM, ACETYLCHOLINESTERASE, HEXAETHYLENE GLYCOL | 著者 | Bourne, Y, Radic, Z, Taylor, P, Marchot, P. | 登録日 | 2010-10-20 | 公開日 | 2010-12-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Conformational Remodeling of Femtomolar Inhibitor-Acetylcholinesterase Complexes in the Crystalline State J.Am.Chem.Soc., 132, 2010
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3PKZ
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![BU of 3pkz by Molmil](/molmil-images/mine/3pkz) | Structural basis for catalytic activation of a serine recombinase | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Recombinase Sin, ... | 著者 | Keenholtz, R.A, Boocock, M.R, Rowland, S.J, Stark, W.M, Rice, P.A. | 登録日 | 2010-11-12 | 公開日 | 2011-06-15 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for catalytic activation of a serine recombinase. Structure, 19, 2011
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4C11
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![BU of 4c11 by Molmil](/molmil-images/mine/4c11) | |
4RO4
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![BU of 4ro4 by Molmil](/molmil-images/mine/4ro4) | |
4RP1
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![BU of 4rp1 by Molmil](/molmil-images/mine/4rp1) | |
1LPN
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![BU of 1lpn by Molmil](/molmil-images/mine/1lpn) | |
3FL6
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![BU of 3fl6 by Molmil](/molmil-images/mine/3fl6) | |
1ZG5
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![BU of 1zg5 by Molmil](/molmil-images/mine/1zg5) | NarL complexed to narG-89 promoter palindromic tail-to-tail DNA site | 分子名称: | 5'-D(*CP*GP*TP*AP*CP*CP*CP*CP*TP*AP*TP*AP*GP*GP*GP*GP*TP*AP*CP*G)-3', Nitrate/nitrite response regulator protein narL, SULFATE ION | 著者 | Maris, A.E, Kaczor-Grzeskowiak, M, Ma, Z, Kopka, M.L, Gunsalus, R.P, Dickerson, R.E. | 登録日 | 2005-04-20 | 公開日 | 2005-11-22 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Primary and Secondary Modes of DNA Recognition by the NarL Two-Component Response Regulator. Biochemistry, 44, 2005
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