8RQG
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5NJ3
| Structure of an ABC transporter: complete structure | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ... | 著者 | Taylor, N.M.I, Manolaridis, I, Jackson, S.M, Kowal, J, Stahlberg, H, Locher, K.P. | 登録日 | 2017-03-28 | 公開日 | 2017-06-07 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Structure of the human multidrug transporter ABCG2. Nature, 546, 2017
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5U0S
| Cryo-EM structure of the Mediator-RNAPII complex | 分子名称: | Mediator complex subunit 10, Mediator complex subunit 11, Mediator complex subunit 14, ... | 著者 | Tsai, K.-L, Yu, X, Gopalan, S, Chao, T.-C, Zhang, Y, Florens, L, Washburn, M.P, Murakami, K, Conaway, R.C, Conaway, J.W, Asturias, F. | 登録日 | 2016-11-26 | 公開日 | 2017-03-08 | 最終更新日 | 2020-01-01 | 実験手法 | ELECTRON MICROSCOPY (7.8 Å) | 主引用文献 | Mediator structure and rearrangements required for holoenzyme formation. Nature, 544, 2017
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1H7V
| Rubredoxin from Guillardia Theta | 分子名称: | RUBREDOXIN, ZINC ION | 著者 | Schweimer, K, Hoffmann, S, Wastl, J, Maier, U.G, Roesch, P, Sticht, H. | 登録日 | 2001-01-16 | 公開日 | 2002-01-29 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a zinc substituted eukaryotic rubredoxin from the cryptomonad alga Guillardia theta. Protein Sci., 9, 2000
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5EE7
| Crystal structure of the human glucagon receptor (GCGR) in complex with the antagonist MK-0893 | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, 3-[[4-[(1~{S})-1-[3-[3,5-bis(chloranyl)phenyl]-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]phenyl]carbonylamino]propanoic acid, Glucagon receptor,Endolysin,Glucagon receptor, ... | 著者 | Jazayeri, A, Dore, A.S, Lamb, D, Krishnamurthy, H, Southall, S.M, Baig, A.H, Bortolato, A, Koglin, M, Robertson, N.J, Errey, J.C, Andrews, S.P, Brown, A.J.H, Cooke, R.M, Weir, M, Marshall, F.H. | 登録日 | 2015-10-22 | 公開日 | 2016-04-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Extra-helical binding site of a glucagon receptor antagonist. Nature, 533, 2016
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2PIT
| Androgen receptor LBD with small molecule | 分子名称: | 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION, ... | 著者 | Estebanez-Perpina, E, Arnold, A.A, Baxter, J.D, Webb, P, Guy, R.K, Fletterick, K.R. | 登録日 | 2007-04-13 | 公開日 | 2007-09-25 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | A surface on the androgen receptor that allosterically regulates coactivator binding. Proc.Natl.Acad.Sci.Usa, 104, 2007
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3ZIM
| Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kalpha | 分子名称: | 1-[4-[[2-(1H-indazol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-6-methyl-hept-5-ene-1,4- dione, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM | 著者 | Nacht, M, Qiao, L, Sheets, M.P, Martin, T.S, Labenski, M, Mazdiyasni, H, Karp, R, Zhu, Z, Chaturvedi, P, Bhavsar, D, Niu, D, Westlin, W, Petter, R.C, Medikonda, A.P, Jestel, A, Blaesse, M, Singh, J. | 登録日 | 2013-01-09 | 公開日 | 2013-02-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Discovery of a Potent and Isoform-Selective Targeted Covalent Inhibitor of the Lipid Kinase Pi3Kalpha J.Med.Chem., 56, 2013
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7KMO
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7UFO
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6NKA
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8RH2
| Trimeric HSV-2G gB ectodomain in postfusion conformation with three bound HDIT102 Fab molecules. | 分子名称: | Envelope glycoprotein B, HDIT102 Fab heavy chain, HDIT102 Fab light chain | 著者 | Kalbermatter, D, Seyfizadeh, N, Imhof, T, Ries, M, Mueller, C, Jenner, L, Blumenschein, E, Yendrzheyevskiy, A, Moog, K, Eckert, D, Engel, R, Diebolder, P, Chami, M, Krauss, J, Schaller, T, Arndt, M. | 登録日 | 2023-12-14 | 公開日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus. J.Biomed.Sci., 31, 2024
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2WD7
| PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00066750 | 分子名称: | 6-chloro-1H-benzimidazol-2-amine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PTERIDINE REDUCTASE | 著者 | Robinson, D.A, Wyatt, P.G, Spinks, D, Brenk, R. | 登録日 | 2009-03-20 | 公開日 | 2009-06-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening. J.Med.Chem., 52, 2009
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5MO8
| Crystal Structure of CK2alpha with N-(3-(((2-chloro-[1,1'-biphenyl]-4-yl)methyl)amino)propyl)methanesulfonamide bound | 分子名称: | 3-[[3-[3-[(3-chloranyl-4-phenyl-phenyl)methylamino]propylamino]-3-oxidanylidene-propanoyl]amino]benzoic acid, ACETATE ION, Casein kinase II subunit alpha, ... | 著者 | Brear, P, De Fusco, C, Georgiou, K, Iegre, J, Sore, H, Hyvonen, M, Spring, D. | 登録日 | 2016-12-13 | 公開日 | 2017-05-24 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066. Bioorg. Med. Chem., 25, 2017
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4ETO
| Structure of S100A4 in complex with non-muscle myosin-IIA peptide | 分子名称: | CALCIUM ION, Myosin-9, Protein S100-A4 | 著者 | Ramagopal, U.A, Dulyaninova, N.G, Kumar, P.R, Almo, S.C, Bresnick, A.R, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | 登録日 | 2012-04-24 | 公開日 | 2012-07-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Structure of S100A4 with bound peptide P To be Published
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1YIJ
| Crystal Structure Of Telithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui | 分子名称: | 23S Ribosomal RNA, 50S RIBOSOMAL PROTEIN L10E, 50S RIBOSOMAL PROTEIN L11P, ... | 著者 | Tu, D, Blaha, G, Moore, P.B, Steitz, T.A. | 登録日 | 2005-01-12 | 公開日 | 2005-04-26 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell(Cambridge,Mass.), 121, 2005
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8V2O
| Cryo-EM Structure of Wildtype Smooth Muscle Gamma Actin (ACTG2) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, gamma-enteric smooth muscle, ... | 著者 | Palmer, N.J, Carman, P.J, Ceron, R.H, Dominguez, R. | 登録日 | 2023-11-23 | 公開日 | 2024-05-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.45 Å) | 主引用文献 | Molecular mechanisms linking missense ACTG2 mutations to visceral myopathy. Sci Adv, 10, 2024
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8QTA
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8QT6
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8QT9
| Cryo-EM structure of stably reduced Streptococcus pneumoniae NADPH oxidase in complex with NADH | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FAD-binding FR-type domain-containing protein, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Dubach, V.R.A, San Segundo-Acosta, P, Murphy, B.J. | 登録日 | 2023-10-12 | 公開日 | 2024-07-24 | 最終更新日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (2.36 Å) | 主引用文献 | Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase. Nat.Struct.Mol.Biol., 2024
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2WE0
| EBV dUTPase mutant Cys4Ser | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, MALATE LIKE INTERMEDIATE, ... | 著者 | Freeman, L, Buisson, M, Tarbouriech, N, Burmeister, W.P. | 登録日 | 2009-03-27 | 公開日 | 2009-07-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | The Flexible Motif V of Epstein-Barr Virus Deoxyuridine 5'-Triphosphate Pyrophosphatase is Essential for Catalysis. J.Biol.Chem., 284, 2009
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8QT7
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2W89
| Crystal structure of the E.coli tRNAArg aminoacyl stem issoacceptor RR-1660 at 2.0 Angstroem resolution | 分子名称: | 5'-R(*CP*GP*GP*AP*UP*GP*CP)-3', 5'-R(*GP*CP*AP*UP*CP*CP*GP)-3', GLYCEROL | 著者 | Eichert, A, Schreiber, A, Fuerste, J.P, Perbandt, M, Betzel, C, Erdmann, V.A, Foerster, C. | 登録日 | 2009-01-15 | 公開日 | 2009-11-17 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of the E. Coli tRNA(Arg) Aminoacyl Stem Isoacceptor Rr-1660 at 2.0 A Resolution. Biochem.Biophys.Res.Commun., 385, 2009
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8VI3
| TehA from Haemophilus influenzae purified in GDN | 分子名称: | Tellurite resistance protein TehA homolog | 著者 | Catalano, C, Senko, S, Tran, N.L, Lucier, K.W, Farwell, A.C, Silva, M.S, Dip, P.V, Poweleit, N, Scapin, G. | 登録日 | 2024-01-03 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy. Int J Mol Sci, 25, 2024
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3SGK
| Unique carbohydrate/carbohydrate interactions are required for high affinity binding of FcgIII and antibodies lacking core fucose | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)][2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fc fragment, ... | 著者 | Ferrara, C, Grau, S, Jaeger, C, Sondermann, P, Bruenker, P, Waldhauer, I, Hennig, M, Ruf, A, Rufer, A.C, Stihle, M, Umana, P, Benz, J. | 登録日 | 2011-06-15 | 公開日 | 2011-08-03 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose. Proc.Natl.Acad.Sci.USA, 108, 2011
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1YLU
| The structure of E. coli nitroreductase with bound acetate, crystal form 2 | 分子名称: | ACETATE ION, FLAVIN MONONUCLEOTIDE, Oxygen-insensitive NAD(P)H nitroreductase | 著者 | Race, P.R, Lovering, A.L, Green, R.M, Ossor, A, White, S.A, Searle, P.F, Wrighton, C.J, Hyde, E.I. | 登録日 | 2005-01-19 | 公開日 | 2005-02-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme. J.Biol.Chem., 280, 2005
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