8EOX
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7PD2
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![BU of 7pd2 by Molmil](/molmil-images/mine/7pd2) | Crystal structure of the substrate-free radical SAM tyrosine lyase ThiH (2-iminoacetate synthase) from Thermosinus carboxydivorans | 分子名称: | 5'-DEOXYADENOSINE, GLYCEROL, IRON/SULFUR CLUSTER, ... | 著者 | Amara, P, Saragaglia, C, Mouesca, J.-M, Martin, L, Nicolet, Y. | 登録日 | 2021-08-04 | 公開日 | 2022-05-11 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | L-tyrosine-bound ThiH structure reveals C-C bond break differences within radical SAM aromatic amino acid lyases. Nat Commun, 13, 2022
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6I49
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![BU of 6i49 by Molmil](/molmil-images/mine/6i49) | Structure of P. aeruginosa LpxC with compound 17a: (2R)-N-Hydroxy-2-methyl-2-(methylsulfonyl)-4(6((4(morpholinomethyl)phenyl)ethynyl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)yl)butanamide | 分子名称: | (2~{R})-2-methyl-2-methylsulfonyl-4-[6-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]-3-oxidanylidene-1~{H}-pyrrolo[1,2-c]imidazol-2-yl]-~{N}-oxidanyl-butanamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION | 著者 | Surivet, J.-P, Panchaud, P, Specklin, J.-L, Diethelm, S, Blumstein, A.-C, Gauvin, J.-C, Jacob, L, Masse, F, Mathieu, G, Mirre, A, Schmitt, C, Enderlin-Paput, M, Lange, R, Bur, D, Tidten-Luksch, N, Gnerre, C, Seeland, S, Hermann, C, Locher, H.H, Seiler, P, Mac Sweeney, A, Hubschwerlen, C, Ritz, D, Rueedi, G. | 登録日 | 2018-11-09 | 公開日 | 2019-12-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria. J.Med.Chem., 63, 2020
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7P37
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![BU of 7p37 by Molmil](/molmil-images/mine/7p37) | Streptomyces coelicolor ATP-loaded NrdR | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Transcriptional repressor NrdR, ZINC ION | 著者 | Martinez-Carranza, M, Stenmark, P. | 登録日 | 2021-07-07 | 公開日 | 2022-05-11 | 最終更新日 | 2022-06-08 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases. Nat Commun, 13, 2022
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7ZAW
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![BU of 7zaw by Molmil](/molmil-images/mine/7zaw) | GPC3-Unc5D octamer structure and role in cell migration | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glypican-3 | 著者 | Akkermans, O, Delloye-Bourgeois, C, Peregrina, C, Carrasquero, M, Kokolaki, M, Berbeira-Santana, M, Chavent, M, Reynaud, F, Ritu, R, Agirre, J, Aksu, M, White, E, Lowe, E, Ben Amar, D, Zaballa, S, Huo, J, Pakos, I, McCubbin, P, Comoletti, D, Owens, R, Robinson, C, Castellani, V, del Toro, D, Seiradake, E. | 登録日 | 2022-03-22 | 公開日 | 2022-11-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | GPC3-Unc5 receptor complex structure and role in cell migration. Cell, 185, 2022
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6ZZ8
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![BU of 6zz8 by Molmil](/molmil-images/mine/6zz8) | MB_CRS6-15 bound to CrSAS-6_6HR | 分子名称: | Centriole protein, Protein B | 著者 | Hatzopoulos, G.N, Kukenshoner, T, Banterle, N, Favez, T, Fluckiger, I, Hantschel, O, Gonczy, P. | 登録日 | 2020-08-04 | 公開日 | 2021-07-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.73 Å) | 主引用文献 | Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly. Nat Commun, 12, 2021
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6S2N
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8EHH
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![BU of 8ehh by Molmil](/molmil-images/mine/8ehh) | Crystal structure of the class A extended-spectrum beta-lactamase CTX-M-96 in complex with relebactam at 1.03 Angstrom resolution | 分子名称: | (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | 著者 | Power, P, Ghiglione, B, Bonomo, R.A, Rodriguez, M.M, Gutkind, G, Klinke, S. | 登録日 | 2022-09-14 | 公開日 | 2023-09-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.03 Å) | 主引用文献 | Biochemical and structural evidences of the activity of relebactam as inhibitor of the extended-spectrum beta-lactamase CTX-M-96. To be published
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7PD1
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![BU of 7pd1 by Molmil](/molmil-images/mine/7pd1) | Crystal structure of the L-tyrosine-bound radical SAM tyrosine lyase ThiH (2-iminoacetate synthase) from Thermosinus carboxydivorans | 分子名称: | 5'-DEOXYADENOSINE, BROMIDE ION, GLYCEROL, ... | 著者 | Amara, P, Saragaglia, C, Mouesca, J.-M, Martin, L, Nicolet, Y. | 登録日 | 2021-08-04 | 公開日 | 2022-05-11 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | L-tyrosine-bound ThiH structure reveals C-C bond break differences within radical SAM aromatic amino acid lyases. Nat Commun, 13, 2022
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7P3Q
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3VD1
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![BU of 3vd1 by Molmil](/molmil-images/mine/3vd1) | structure of p73 DNA binding domain tetramer modulates p73 transactivation | 分子名称: | DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3'), Tumor protein p73, ZINC ION | 著者 | Ethayathulla, A.S, Tse, P.W, Nguyen, S, Viadiu, H. | 登録日 | 2012-01-04 | 公開日 | 2012-04-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structure of p73 DNA-binding domain tetramer modulates p73 transactivation. Proc.Natl.Acad.Sci.USA, 109, 2012
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7OZX
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![BU of 7ozx by Molmil](/molmil-images/mine/7ozx) | Structure of human galactokinase 1 bound with azepan-1-yl(2,6-difluorophenyl)methanone | 分子名称: | (azepan-1-yl)(2,6-difluorophenyl)methanone, 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, Galactokinase, ... | 著者 | Mackinnon, S.R, Bezerra, G.A, Zhang, M, Foster, W, Krojer, T, Brandao-Neto, J, Arrowsmith, C, Edwards, A, Bountra, C, Brennan, P, Lai, K, Yue, W.W. | 登録日 | 2021-06-29 | 公開日 | 2022-05-25 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of human galactokinase 1 bound with azepan-1-yl(2,6-difluorophenyl)methanone To Be Published
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7RUE
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![BU of 7rue by Molmil](/molmil-images/mine/7rue) | DAHP synthase complexed with trifluoropyruvate semicarbazone | 分子名称: | (2E)-2-(2-carbamoylhydrazinylidene)-3,3,3-trifluoropropanoic acid, MANGANESE (II) ION, Phospho-2-dehydro-3-deoxyheptonate aldolase, ... | 著者 | Heimhalt, M, Mukherjee, P, Grainger, R, Szabla, R, Brown, C, Turner, R, Junop, M.S, Berti, P.J. | 登録日 | 2021-08-16 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhibition. Acs Infect Dis., 7, 2021
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8C8C
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![BU of 8c8c by Molmil](/molmil-images/mine/8c8c) | Crystal Structure of Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PI5P4Ka) bound to an inhibitor | 分子名称: | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, ~{N}-(3-chloranyl-4-methoxy-phenyl)-7-(3,4-dimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine | 著者 | Harborne, S.P.D, Howard, T.D, Ogg, D.T. | 登録日 | 2023-01-19 | 公開日 | 2023-04-26 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.096 Å) | 主引用文献 | Identification of ARUK2002821 as an isoform-selective PI5P4K alpha inhibitor. Rsc Med Chem, 14, 2023
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4X5R
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![BU of 4x5r by Molmil](/molmil-images/mine/4x5r) | Crystal structure of FimH in complex with a squaryl-phenyl alpha-D-mannopyranoside derivative | 分子名称: | 2-chloro-4-{[2-(4-methylpiperazin-1-yl)-3,4-dioxocyclobut-1-en-1-yl]amino}phenyl alpha-D-mannopyranoside, Protein FimH, SULFATE ION | 著者 | Preston, R.C, Jakob, R.P, Fiege, B, Zihlmann, P, Rabbani, S, Schwardt, O, Jiang, X, Ernst, B, Maier, T. | 登録日 | 2014-12-05 | 公開日 | 2015-05-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography. Chembiochem, 16, 2015
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8EZT
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![BU of 8ezt by Molmil](/molmil-images/mine/8ezt) | Crystal structure of HipB(Lp) from Legionella pneumophila | 分子名称: | CHLORIDE ION, HipB(Lp) | 著者 | Stogios, P.J, Skarina, T, Di Leo, R, Lin, J, Ensminger, A, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2022-11-01 | 公開日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Crystal structure of HipB(Lp) from Legionella pneumophila To Be Published
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8EZS
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![BU of 8ezs by Molmil](/molmil-images/mine/8ezs) | Crystal structure of the HipS(Lp)-HipT(Lp) complex from Legionella pneumophila, Sel-met protein | 分子名称: | CHLORIDE ION, HipS(Lp), HipT(Lp) | 著者 | Stogios, P.J, Skarina, T, Michalska, K, Di Leo, R, Lin, J, Ensminger, A, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2022-11-01 | 公開日 | 2023-09-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Crystal structure of the HipS(Lp)-HipT(Lp) complex from Legionella pneumophila, Sel-met protein To Be Published
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7MX6
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![BU of 7mx6 by Molmil](/molmil-images/mine/7mx6) | Leishmania major dihydroorotate dehydrogenase in complex with [4-(1H-pyrrol-1-yl)phenyl]methanol | 分子名称: | 4-(1H-pyrrol-1-yl)aniline, Dihydroorotate dehydrogenase (fumarate), FLAVIN MONONUCLEOTIDE, ... | 著者 | Pinheiro, M.P, Hunter, W.N, Cardoso, I.A, Nonato, M.C. | 登録日 | 2021-05-18 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Leishmania major dihydroorotate dehydrogenase in complex with [4-(1H-pyrrol-1-yl)phenyl]methanol To be Published
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6ZVR
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![BU of 6zvr by Molmil](/molmil-images/mine/6zvr) | C11 symmetry: Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily. | 分子名称: | Vipp1 | 著者 | Liu, J.W, Tassinari, M, Souza, D.P, Naskar, S, Noel, J.K, Bohuszewicz, O, Buck, M, Williams, T.A, Baum, B, Low, H.H. | 登録日 | 2020-07-27 | 公開日 | 2021-08-04 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (8.2 Å) | 主引用文献 | Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily. Cell, 184, 2021
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6ZW4
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![BU of 6zw4 by Molmil](/molmil-images/mine/6zw4) | C14 symmetry: Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily. | 分子名称: | vipp1 | 著者 | Liu, J.W, Tassinari, M, Souza, D.P, Naskar, S, Noel, J.K, Bohuszewicz, O, Buck, M, Williams, T.A, Baum, B, Low, H.H. | 登録日 | 2020-07-27 | 公開日 | 2021-08-04 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily. Cell, 184, 2021
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6ZW5
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![BU of 6zw5 by Molmil](/molmil-images/mine/6zw5) | C15 symmetry: Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily. | 分子名称: | vipp1 | 著者 | Liu, J.W, Tassinari, M, Souza, D.P, Naskar, S, Noel, J.K, Bohuszewicz, O, Buck, M, Williams, T.A, Baum, B, Low, H.H. | 登録日 | 2020-07-27 | 公開日 | 2021-08-04 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily. Cell, 184, 2021
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6M24
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![BU of 6m24 by Molmil](/molmil-images/mine/6m24) | Uncommon structural features of rabbit MHC class I (RLA-A1) complexed with rabbit haemorrhagic disease virus (RHDV) derived peptide, VP60-2 | 分子名称: | Beta-2-microglobulin, RLA class I histocompatibility antigen, alpha chain 19-1, ... | 著者 | Zhang, Q.X, Liu, K.F, Yue, C, Zhang, D, Lu, D, Xiao, W.L, Liu, P.P, Zhao, Y.Z, Gao, G.L, Ding, C.M, Lyu, J.X, Liu, W.J. | 登録日 | 2020-02-26 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Strict Assembly Restriction of Peptides from Rabbit Hemorrhagic Disease Virus Presented by Rabbit Major Histocompatibility Complex Class I Molecule RLA-A1. J.Virol., 94, 2020
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8T76
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![BU of 8t76 by Molmil](/molmil-images/mine/8t76) | SpRY-Cas9:gRNA complex targeting TAC PAM DNA with 3 bp R-loop | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ... | 著者 | Hibshman, G.N, Bravo, J.P.K, Taylor, D.W. | 登録日 | 2023-06-19 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9. Nat Commun, 15, 2024
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6ZVS
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![BU of 6zvs by Molmil](/molmil-images/mine/6zvs) | C12 symmetry: Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily. | 分子名称: | Vipp1 | 著者 | Liu, J, Tassinari, M, Souza, D.P, Naskar, S, Noel, J.K, Bohuszewicz, O, Buck, M, Williams, T.A, Baum, B, Low, H.H. | 登録日 | 2020-07-27 | 公開日 | 2021-08-04 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | 主引用文献 | Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily. Cell, 184, 2021
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6ZVT
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![BU of 6zvt by Molmil](/molmil-images/mine/6zvt) | C13 symmetry: Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily. | 分子名称: | Vipp1 | 著者 | Liu, J.W, Tassinari, M, Souza, D.P, Naskar, S, Noel, J.K, Bohuszewicz, O, Buck, M, Williams, T.A, Baum, B, Low, H.H. | 登録日 | 2020-07-27 | 公開日 | 2021-08-04 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily. Cell, 184, 2021
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