5EMW
 
 | | Crystal structure of the palmitoylated human TEAD3 transcription factor | | Descriptor: | CALCIUM ION, Transcriptional enhancer factor TEF-5 | | Authors: | Noland, C.L, Gierke, S, Schnier, P.D, Murray, J, Sandoval, W.N, Sagolla, M, Dey, A, Hannoush, R.N, Fairbrother, W.J, Cunningham, C.N. | | Deposit date: | 2015-11-06 | | Release date: | 2015-12-23 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling.
Structure, 24, 2016
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2W26
 | | Factor Xa in complex with BAY59-7939 | | Descriptor: | 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION | | Authors: | Roehrig, S, Straub, A, Pohlmann, J, Lampe, T, Pernerstorfer, J, Schlemmer, K, Reinemer, P, Perzborn, E, Schaefer, M. | | Deposit date: | 2008-10-24 | | Release date: | 2008-11-11 | | Last modified: | 2021-04-28 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Discovery of the Novel Antithrombotic Agent 5-Chloro-N-({(5S)-2-Oxo-3- [4-(3-Oxomorpholin-4-Yl)Phenyl]-1,3-Oxazolidin-5-Yl}Methyl)Thiophene-2- Carboxamide (Bay 59-7939): An Oral, Direct Factor Xa Inhibitor.
J.Med.Chem., 48, 2005
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6TIK
 | | Hepatitis B virus core shell--virus-like particle with NadA epitope | | Descriptor: | Capsid protein,Putative adhesin/invasin,Capsid protein,Factor H-binding protein | | Authors: | Roseman, A.M, Colllins, R.F, Derrick, J.P. | | Deposit date: | 2019-11-22 | | Release date: | 2020-04-29 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | An assessment of the use of Hepatitis B Virus core protein virus-like particles to display heterologous antigens from Neisseria meningitidis.
Vaccine, 38, 2020
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5EP4
 | | Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Shah, T, Selcuk, H.B, Jeffrey, P.D, Hughson, F.M. | | Deposit date: | 2015-11-11 | | Release date: | 2016-04-20 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO.
Plos Biol., 14, 2016
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2VP3
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2VPM
 | | Trypanothione synthetase | | Descriptor: | BROMIDE ION, CHLORIDE ION, TRYPANOTHIONE SYNTHETASE | | Authors: | Fyfe, P.K, Oza, S.L, Fairlamb, A.H, Hunter, W.N. | | Deposit date: | 2008-03-03 | | Release date: | 2008-05-06 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities.
J.Biol.Chem., 283, 2008
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2WDE
 | | Termus thermophilus Sulfate thiohydrolase SoxB in complex with thiosulfate | | Descriptor: | MANGANESE (II) ION, SULFUR OXIDATION PROTEIN SOXB, TERTIARY-BUTYL ALCOHOL, ... | | Authors: | Sauve, V, Roversi, P, Leath, K.J, Garman, E.F, Antrobus, R, Lea, S.M, Berks, B.C. | | Deposit date: | 2009-03-24 | | Release date: | 2009-06-16 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Mechanism for the Hydrolysis of a Sulfur-Sulfur Bond Based on the Crystal Structure of the Thiosulfohydrolase Soxb.
J.Biol.Chem., 284, 2009
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2WD4
 | | Ascorbate Peroxidase as a heme oxygenase: w41A variant product with t-butyl peroxide | | Descriptor: | 3-[2-[[3-(2-CARBOXYETHYL)-5-[[3-ETHENYL-4-METHYL-5-[(2-METHYLPROPAN-2-YL)OXY]-1H-PYRROL-2-YL]METHYL]-4-METHYL-1H-PYRROL -2-YL]METHYL]-5-[(Z)-(4-ETHENYL-3-METHYL-5-OXO-PYRROL-2-YLIDENE)METHYL]-4-METHYL-1H-PYRROL-3-YL]PROPANOIC ACID, ASCORBATE PEROXIDASE, FE (III) ION, ... | | Authors: | Badyal, S.K, Metcalfe, C.L, Gumiero, A, Raven, E.L, Moody, P.C.E. | | Deposit date: | 2009-03-19 | | Release date: | 2009-04-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Evidence for Heme Oxygenase Activity in a Heme Peroxidase.
Biochemistry, 48, 2009
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5EP3
 | | Quorum-Sensing Signal Integrator LuxO - Catalytic Domain Bound to CV-133 Inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 2,2-dimethylpropyl 2-[(3-oxidanylidene-5-sulfanylidene-2~{H}-1,2,4-triazin-6-yl)amino]ethanoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Shah, T, Selcuk, H.B, Jeffrey, P.D, Hughson, F.M. | | Deposit date: | 2015-11-11 | | Release date: | 2016-04-20 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO.
Plos Biol., 14, 2016
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2W0L
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6T77
 | | Crystal structure of Klebsiella pneumoniae FabG(NADPH-dependent) NADP-complex at 1.75 A resolution | | Descriptor: | 3-oxoacyl-ACP reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Vella, P, Schnell, R, Lindqvist, Y, Schneider, G. | | Deposit date: | 2019-10-21 | | Release date: | 2020-11-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.
Bioorg.Med.Chem., 30, 2021
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2VQX
 | | Precursor of Protealysin, Metalloproteinase from Serratia proteamaculans. | | Descriptor: | METALLOPROTEINASE, ZINC ION | | Authors: | Melik-Adamyan, W.R, Kuranova, I.P, Polyakov, K.M, Demidyuk, I.V, Gromova, T.Y, Kostrov, S.V. | | Deposit date: | 2008-03-20 | | Release date: | 2009-05-26 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.821 Å) | | Cite: | Crystal Structure of the Protealysin Precursor: Insights Into Propeptide Function.
J.Biol.Chem., 285, 2010
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2W5Y
 | | Binary Complex of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine. | | Descriptor: | HISTONE-LYSINE N-METHYLTRANSFERASE HRX, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | | Authors: | Southall, S.M, Wong, P.S, Odho, Z, Roe, S.M, WIlson, J.R. | | Deposit date: | 2008-12-15 | | Release date: | 2009-02-10 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.
Mol.Cell, 33, 2009
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2VW2
 | | Crystal structure of the NanB sialidase from Streptococcus pneumoniae | | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, SIALIDASE B | | Authors: | Xu, G, Potter, J.A, Russell, R.J.M, Oggioni, M.R, Andrew, P.W, Taylor, G.L. | | Deposit date: | 2008-06-13 | | Release date: | 2008-06-24 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal Structure of the Nanb Sialidase from Streptococcus Pneumoniae
J.Mol.Biol., 384, 2008
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5EKL
 | | Crystal structure of Staphylococcal nuclease variant Delta+PHS T62D/N100E at cryogenic temperature | | Descriptor: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | | Authors: | Skerritt, L.A, Bell-Upp, P.C, Schlessman, J.L, Garcia-Moreno E, B. | | Deposit date: | 2015-11-03 | | Release date: | 2015-11-18 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of Staphylococcal nuclease variant Delta+PHS T62D/N100E at cryogenic temperature
To be Published
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2WBH
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2WA2
 | | Structure of the methyltransferase domain from Modoc Virus, a Flavivirus with No Known Vector (NKV) | | Descriptor: | NON-STRUCTURAL PROTEIN 5, S-ADENOSYLMETHIONINE, SULFATE ION | | Authors: | Jansson, A.M, Johansson, P, Jones, T.A. | | Deposit date: | 2009-02-02 | | Release date: | 2009-08-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of the Methyltransferase Domain from the Modoc Virus, a Flavivirus with No Known Vector.
Acta Crystallogr.,Sect.D, 65, 2009
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2WDF
 | | Termus thermophilus Sulfate thiohydrolase SoxB | | Descriptor: | MANGANESE (II) ION, SULFUR OXIDATION PROTEIN SOXB, TERTIARY-BUTYL ALCOHOL | | Authors: | Sauve, V, Roversi, P, Leath, K.J, Garman, E.F, Antrobus, R, Lea, S.M, Berks, B.C. | | Deposit date: | 2009-03-24 | | Release date: | 2009-06-16 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Mechanism for the Hydrolysis of a Sulfur-Sulfur Bond Based on the Crystal Structure of the Thiosulfohydrolase Soxb.
J.Biol.Chem., 284, 2009
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2VXS
 | | Structure of IL-17A in complex with a potent, fully human neutralising antibody | | Descriptor: | FAB FRAGMENT, INTERLEUKIN-17A, SULFATE ION | | Authors: | Gerhardt, S, Hargreaves, D, Pauptit, R.A, Davies, R.A, Russell, C, Welsh, F, Tuske, S.J, Coales, S.J, Hamuro, Y, Needham, M.R.C, Langham, C, Barker, W, Bell, P, Aziz, A, Smith, M.J, Dawson, S, Abbott, W.M. | | Deposit date: | 2008-07-09 | | Release date: | 2009-07-14 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.63 Å) | | Cite: | Structure of Il-17A in Complex with a Potent, Fully Human Neutralising Antibody.
J.Mol.Biol., 394, 2009
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5EU3
 | | HLA Class I antigen | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Rizkallah, P.J, Bianchi, V, Cole, D.K, Sewell, A.K. | | Deposit date: | 2015-11-18 | | Release date: | 2016-03-02 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.
J.Biol.Chem., 291, 2016
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2VWL
 | | Aminopyrrolidine Factor Xa inhibitor | | Descriptor: | 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3R,5S)-1-{[2-FLUORO-4-(2-OXO-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-5-HYDROXYMETHYL-PYRROLIDIN-3-YL)-AMIDE, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION, ... | | Authors: | Groebke-Zbinden, K, Banner, D.W, Benz, J.M, Blasco, F, Decoret, G, Himber, J, Kuhn, B, Panday, N, Ricklin, F, Risch, P, Schlatter, D, Stahl, M, Unger, R, Haap, W. | | Deposit date: | 2008-06-26 | | Release date: | 2009-07-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.
Eur.J.Med.Chem., 44, 2009
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2VXR
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2W7U
 | | SplA serine protease of Staphylococcus aureus (2.4A) | | Descriptor: | SERINE PROTEASE SPLA | | Authors: | Stec-Niemczyka, J, Pustelny, K, Kisielewska, M, Bista, M, Boulware, K.T, Stennicke, H.R, Thogersen, I.B, Daugherty, P.S, Enghild, J.J, Popowicz, G.M, Dubin, A, Potempa, J, Dubin, G. | | Deposit date: | 2008-12-30 | | Release date: | 2010-03-31 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Structural and Functional Characterization of Spla, an Exclusively Specific Protease of Staphylococcus Aureus.
Biochem.J., 419, 2009
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9BCM
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9BF6
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