PDB Search results for query - Protein Data Bank Japan

PDB: 103 results

Discovery and clinical validation of RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
Descriptor:	Fibroblast growth factor receptor 2, N-{4-[(5P)-4-amino-5-{3-fluoro-4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}-2-methylpropanamide
Authors:	Valverde, R, Foster, L.
Deposit date:	2023-05-10
Release date:	2023-06-07
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (3.79 Å)
Cite:	RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations. Cancer Discov, 13, 2023

FGFR2 Kinase Domain Bound to Reversible Inhibitor Cmpd 3
Descriptor:	Fibroblast growth factor receptor 2, GLUTATHIONE, GLYCEROL, ...
Authors:	Valverde, R, Foster, L.
Deposit date:	2023-05-18
Release date:	2024-02-14
Method:	X-RAY DIFFRACTION (2.24 Å)
Cite:	Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2. Proc.Natl.Acad.Sci.USA, 121, 2024

FGFR2 Kinase Domain Bound to Irreversible Inhibitor Cmpd 10
Descriptor:	Fibroblast growth factor receptor 2, GLYCEROL, N-[4-(4-amino-7-methyl-5-{4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-2-methylpropanamide, ...
Authors:	Valverde, R, Foster, L.
Deposit date:	2023-08-31
Release date:	2024-02-14
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (3.33 Å)
Cite:	Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2. Proc.Natl.Acad.Sci.USA, 121, 2024