5H9V
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![BU of 5h9v by Molmil](/molmil-images/mine/5h9v) | Crystal structure of Regnase PIN domain, form I | Descriptor: | Ribonuclease ZC3H12A, SODIUM ION | Authors: | Yokogawa, M, Tsushima, T, Adachi, W, Noda, N.N, Inagaki, F. | Deposit date: | 2015-12-29 | Release date: | 2016-03-16 | Last modified: | 2020-02-19 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions Sci Rep, 6, 2016
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5H9W
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![BU of 5h9w by Molmil](/molmil-images/mine/5h9w) | Crystal structure of Regnase PIN domain, form II | Descriptor: | Ribonuclease ZC3H12A, SODIUM ION | Authors: | Yokogawa, M, Tsushima, T, Adachi, W, Noda, N.N, Inagaki, F. | Deposit date: | 2015-12-29 | Release date: | 2016-03-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions Sci Rep, 6, 2016
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2N5L
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![BU of 2n5l by Molmil](/molmil-images/mine/2n5l) | Regnase-1 C-terminal domain | Descriptor: | Ribonuclease ZC3H12A | Authors: | Yokogawa, M, Tsushima, T, Noda, N.N, Kumeta, H, Adachi, W, Enokizono, Y, Yamashita, K, Standley, D.M, Takeuchi, O, Akira, S, Inagaki, F. | Deposit date: | 2015-07-18 | Release date: | 2016-03-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions Sci Rep, 6, 2016
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2N5J
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![BU of 2n5j by Molmil](/molmil-images/mine/2n5j) | Regnase-1 N-terminal domain | Descriptor: | Ribonuclease ZC3H12A | Authors: | Yokogawa, M, Tsushima, T, Noda, N.N, Kumeta, H, Adachi, W, Enokizono, Y, Yamashita, K, Standley, D.M, Takeuchi, O, Akira, S, Inagaki, F. | Deposit date: | 2015-07-18 | Release date: | 2016-03-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions Sci Rep, 6, 2016
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2N5K
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![BU of 2n5k by Molmil](/molmil-images/mine/2n5k) | Regnase-1 Zinc finger domain | Descriptor: | Ribonuclease ZC3H12A, ZINC ION | Authors: | Yokogawa, M, Tsushima, T, Noda, N.N, Kumeta, H, Adachi, W, Enokizono, Y, Yamashita, K, Standley, D.M, Takeuchi, O, Akira, S, Inagaki, F. | Deposit date: | 2015-07-18 | Release date: | 2016-03-16 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions Sci Rep, 6, 2016
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4G1A
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![BU of 4g1a by Molmil](/molmil-images/mine/4g1a) | |
5YGY
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![BU of 5ygy by Molmil](/molmil-images/mine/5ygy) | Crystal Structure of BACE1 in complex with (S)-N-(3-(2-amino-6-(fluoromethyl)-4 -methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide | Descriptor: | Beta-secretase 1, GLYCEROL, IODIDE ION, ... | Authors: | Fuchino, K, Mitsuoka, Y, Masui, M, Kurose, N, Yoshida, S, Komano, K, Yamamoto, T, Ogawa, M, Unemura, C, Hosono, M, Ito, H, Sakaguchi, G, Ando, S, Ohnishi, S, Kido, Y, Fukushima, T, Miyajima, H, Hiroyama, S, Koyabu, K, Dhuyvetter, D, Borghys, H, Gijsen, H, Yamano, Y, Iso, Y, Kusakabe, K. | Deposit date: | 2017-09-27 | Release date: | 2018-05-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Rational Design of Novel 1,3-Oxazine Based beta-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust A beta Reduction in the Brain J. Med. Chem., 61, 2018
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5YGX
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![BU of 5ygx by Molmil](/molmil-images/mine/5ygx) | Structure of BACE1 in complex with N-(3-((4R,5R,6S)-2-amino-6-(1,1-difluoroethyl)-5-fluoro-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide | Descriptor: | Beta-secretase 1, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Nakahara, K, Fuchino, K, Komano, K, Asada, N, Tadano, G, Hasegawa, T, Yamamoto, T, Sako, Y, Ogawa, M, Unemura, C, Hosono, M, Sakaguchi, G, Ando, S, Ohnishi, S, Kido, Y, Fukushima, T, Dhuyvetter, D, Borghys, H, Gijsen, H, Yamano, Y, Iso, Y, Kusakabe, K. | Deposit date: | 2017-09-27 | Release date: | 2018-08-08 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine beta-Secretase (BACE1) Inhibitors via Active Conformation Stabilization J. Med. Chem., 61, 2018
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7BWI
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![BU of 7bwi by Molmil](/molmil-images/mine/7bwi) | Solution structure of recombinant APETx1 | Descriptor: | Kappa-actitoxin-Ael2a | Authors: | Matsumura, K, Kobayashi, N, Kurita, J, Nishimura, Y, Yokogawa, M, Imai, S, Shimada, I, Osawa, M. | Deposit date: | 2020-04-14 | Release date: | 2020-12-23 | Last modified: | 2021-07-14 | Method: | SOLUTION NMR | Cite: | Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization. Bmc Mol Cell Biol, 22, 2021
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3WX0
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![BU of 3wx0 by Molmil](/molmil-images/mine/3wx0) | |