3H4G
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![BU of 3h4g by Molmil](/molmil-images/mine/3h4g) | Structure of aldehyde reductase holoenzyme in complex with potent aldose reductase inhibitor Fidarestat: Implications for inhibitor binding and selectivity | Descriptor: | (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, Alcohol dehydrogenase [NADP+], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Carbone, V, El-Kabbani, O. | Deposit date: | 2009-04-20 | Release date: | 2009-05-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity J.Med.Chem., 48, 2005
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3GJN
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6DB1
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![BU of 6db1 by Molmil](/molmil-images/mine/6db1) | 2.0 Angstrom Resolution Crystal Structure of N-Terminal Ligand-Binding Domain of Putative Methyl-Accepting Chemotaxis Protein from Salmonella enterica | Descriptor: | CHLORIDE ION, Putative methyl-accepting chemotaxis protein | Authors: | Minasov, G, Shuvalova, L, Dubrovska, I, Kiryukhina, O, Grimshaw, S, Kwon, K, Anderson, W.F, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2018-05-02 | Release date: | 2018-05-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 2.0 Angstrom Resolution Crystal Structure of N-Terminal Ligand-Binding Domain of Putative Methyl-Accepting Chemotaxis Protein from Salmonella enterica. To Be Published
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1IYT
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![BU of 1iyt by Molmil](/molmil-images/mine/1iyt) | Solution structure of the Alzheimer's disease amyloid beta-peptide (1-42) | Descriptor: | Alzheimer's disease amyloid | Authors: | Crescenzi, O, Tomaselli, S, Guerrini, R, Salvadori, S, D'Ursi, A.M, Temussi, P.A, Picone, D. | Deposit date: | 2002-09-06 | Release date: | 2003-02-11 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain. EUR.J.BIOCHEM., 269, 2002
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1J8D
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3G5K
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![BU of 3g5k by Molmil](/molmil-images/mine/3g5k) | Structure and activity of human mitochondrial peptide deformylase, a novel cancer target | Descriptor: | ACTINONIN, COBALT (II) ION, Peptide deformylase, ... | Authors: | Escobar-Alvarez, S, Goldgur, Y, Yang, G, Ouerfelli, O, Li, Y, Scheinberg, D.A. | Deposit date: | 2009-02-05 | Release date: | 2009-04-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and activity of human mitochondrial peptide deformylase, a novel cancer target J.Mol.Biol., 387, 2009
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6D72
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![BU of 6d72 by Molmil](/molmil-images/mine/6d72) | Crystal structure of spermidine/spermine N-acetyltransferase SpeG from Yersinia pestis in complex with calcium ions. | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, MALONATE ION, ... | Authors: | Filippova, E.V, Minasov, G, Kiryukhina, O, Anderson, W.F, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2018-04-23 | Release date: | 2018-05-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Crystal structure of spermidine/spermine N-acetyltransferase SpeG from Yersinia pestis in complex with calcium ions. To Be Published
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3G25
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![BU of 3g25 by Molmil](/molmil-images/mine/3g25) | 1.9 Angstrom Crystal Structure of Glycerol Kinase (glpK) from Staphylococcus aureus in Complex with Glycerol. | Descriptor: | GLYCEROL, Glycerol kinase, PHOSPHATE ION, ... | Authors: | Minasov, G, Skarina, T, Onopriyenko, O, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2009-01-30 | Release date: | 2009-02-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | 1.9 Angstrom Crystal Structure of Glycerol Kinase (glpK) from Staphylococcus aureus in Complex with Glycerol. TO BE PUBLISHED
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1IJA
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![BU of 1ija by Molmil](/molmil-images/mine/1ija) | Structure of Sortase | Descriptor: | Sortase | Authors: | Ilangovan, U, Ton-That, H, Iwahara, J, Schneewind, O, Clubb, R.T. | Deposit date: | 2001-04-25 | Release date: | 2001-05-09 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure of sortase, the transpeptidase that anchors proteins to the cell wall of Staphylococcus aureus. Proc.Natl.Acad.Sci.USA, 98, 2001
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1NVJ
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![BU of 1nvj by Molmil](/molmil-images/mine/1nvj) | Deletion Mutant (Delta 141) of Molybdopterin Synthase | Descriptor: | FORMIC ACID, GLYCEROL, Molybdopterin converting factor subunit 2, ... | Authors: | Rudolph, M.J, Wuebbens, M.M, Turque, O, Rajagopalan, K.V, Schindelin, H. | Deposit date: | 2003-02-03 | Release date: | 2003-05-06 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural Studies of Molybdopterin Synthase Provide Insights into its Catalytic Mechanism J.Biol.Chem., 278, 2003
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3FT6
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1IQ8
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![BU of 1iq8 by Molmil](/molmil-images/mine/1iq8) | Crystal Structure of archaeosine tRNA-guanine transglycosylase from Pyrococcus horikoshii | Descriptor: | ARCHAEOSINE TRNA-GUANINE TRANSGLYCOSYLASE, MAGNESIUM ION, ZINC ION | Authors: | Ishitani, R, Nureki, O, Fukai, S, Kijimoto, T, Nameki, N, Watanabe, M, Kondo, H, Sekine, M, Okada, N, Nishimura, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2001-07-09 | Release date: | 2002-05-22 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of archaeosine tRNA-guanine transglycosylase. J.Mol.Biol., 318, 2002
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1ILE
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![BU of 1ile by Molmil](/molmil-images/mine/1ile) | ISOLEUCYL-TRNA SYNTHETASE | Descriptor: | ISOLEUCYL-TRNA SYNTHETASE, ZINC ION | Authors: | Nureki, O, Vassylyev, D.G, Tateno, M, Shimada, A, Nakama, T, Fukai, S, Konno, M, Schimmel, P, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 1998-02-24 | Release date: | 1999-04-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Enzyme structure with two catalytic sites for double-sieve selection of substrate. Science, 280, 1998
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1NMN
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![BU of 1nmn by Molmil](/molmil-images/mine/1nmn) | Structure of yqgF from Escherichia coli, a hypothetical protein | Descriptor: | Hypothetical protein yqgF | Authors: | Galkin, A, Sarikaya, E, Krajewski, W, Howard, A, Herzberg, O, Structure 2 Function Project (S2F) | Deposit date: | 2003-01-10 | Release date: | 2004-03-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of yqgF from Escherichia coli, a hypothetical protein To be Published
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3FUP
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![BU of 3fup by Molmil](/molmil-images/mine/3fup) | Crystal structures of JAK1 and JAK2 inhibitor complexes | Descriptor: | 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile, Tyrosine-protein kinase JAK2 | Authors: | Williams, N.K, Bamert, R.S, Patel, O, Fantino, E, Rossjohn, J, Lucet, I.S. | Deposit date: | 2009-01-14 | Release date: | 2009-02-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. J.Mol.Biol., 387, 2009
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1J1U
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![BU of 1j1u by Molmil](/molmil-images/mine/1j1u) | Crystal structure of archaeal tyrosyl-tRNA synthetase complexed with tRNA(Tyr) and L-tyrosine | Descriptor: | MAGNESIUM ION, TYROSINE, Tyrosyl-tRNA synthetase, ... | Authors: | Kobayashi, T, Nureki, O, Ishitani, R, Tukalo, M, Cusack, S, Sakamoto, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2002-12-17 | Release date: | 2003-06-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion NAT.STRUCT.BIOL., 10, 2003
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6DL7
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![BU of 6dl7 by Molmil](/molmil-images/mine/6dl7) | Human mitochondrial ClpP in complex with ONC201 (TIC10) | Descriptor: | 7-benzyl-4-[(2-methylphenyl)methyl]-6,7,8,9-tetrahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one, ATP-dependent Clp protease proteolytic subunit, mitochondrial | Authors: | Halgas, O, Zarabi, S.F, Schimmer, A, Pai, E.F. | Deposit date: | 2018-05-31 | Release date: | 2019-05-08 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality. Cancer Cell, 35, 2019
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1L7A
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3G5S
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![BU of 3g5s by Molmil](/molmil-images/mine/3g5s) | Crystal structure of Thermus thermophilus TrmFO in complex with glutathione | Descriptor: | 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, ... | Authors: | Nishimasu, H, Ishitani, R, Hori, H, Nureki, O. | Deposit date: | 2009-02-05 | Release date: | 2009-05-19 | Last modified: | 2011-12-14 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase Proc.Natl.Acad.Sci.USA, 106, 2009
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1LFK
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![BU of 1lfk by Molmil](/molmil-images/mine/1lfk) | Crystal structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction During Vancomycin Biosynthesis | Descriptor: | P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Pylypenko, O, Zerbe, K, Vitali, F, Zhang, W, Vrijbloed, J.W, Robinson, J.A, Schlichting, I. | Deposit date: | 2002-04-11 | Release date: | 2002-12-11 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis. J.Biol.Chem., 277, 2002
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6DW4
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![BU of 6dw4 by Molmil](/molmil-images/mine/6dw4) | SAMHD1 Bound to Cladribine-TP in the Catalytic Pocket and Allosteric Pocket | Descriptor: | 2'-deoxy-2-methyladenosine 5'-(tetrahydrogen triphosphate), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Knecht, K.M, Buzovetsky, O, Schneider, C, Thomas, D, Srikanth, V, Kaderali, L, Tofoleanu, F, Reiss, K, Ferreiros, N, Geisslinger, G, Batista, V.S, Ji, X, Cinatl, J, Keppler, O.T, Xiong, Y. | Deposit date: | 2018-06-26 | Release date: | 2018-10-10 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1JHT
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![BU of 1jht by Molmil](/molmil-images/mine/1jht) | Crystal structure of HLA-A2*0201 in complex with a nonameric altered peptide ligand (ALGIGILTV) from the MART-1/Melan-A. | Descriptor: | HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, beta-2-microglobulin, ... | Authors: | Sliz, P, Michielin, O, Karplus, M, Romero, P, Wiley, D. | Deposit date: | 2001-06-28 | Release date: | 2001-09-14 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structures of two closely related but antigenically distinct HLA-A2/melanocyte-melanoma tumor-antigen peptide complexes. J.Immunol., 167, 2001
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8B3T
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![BU of 8b3t by Molmil](/molmil-images/mine/8b3t) | Hen Egg White Lysozyme 4s in situ crystallization | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Henkel, A, Galchenkova, M, Yefanov, O, Hakanpaeae, J, Chapman, H.N, Oberthuer, D. | Deposit date: | 2022-09-16 | Release date: | 2022-11-30 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | JINXED: just in time crystallization for easy structure determination of biological macromolecules. Iucrj, 10, 2023
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6D7Y
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![BU of 6d7y by Molmil](/molmil-images/mine/6d7y) | 1.75 Angstrom Resolution Crystal Structure of the Toxic C-Terminal Tip of CdiA from Pseudomonas aeruginosa in Complex with Immune Protein | Descriptor: | Hemagglutinin, immune protein | Authors: | Minasov, G, Shuvalova, L, Wawrzak, Z, Kiryukhina, O, Allen, J.P, Hauser, A.R, Anderson, W.F, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2018-04-25 | Release date: | 2019-05-01 | Last modified: | 2020-04-15 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | A comparative genomics approach identifies contact-dependent growth inhibition as a virulence determinant. Proc.Natl.Acad.Sci.USA, 117, 2020
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8B3U
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![BU of 8b3u by Molmil](/molmil-images/mine/8b3u) | Hen Egg White Lysozyme 6s in situ crystallization | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Henkel, A, Galchenkova, M, Yefanov, O, Hakanpaeae, J, Chapman, H.N, Oberthuer, D. | Deposit date: | 2022-09-16 | Release date: | 2022-11-30 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | JINXED: just in time crystallization for easy structure determination of biological macromolecules. Iucrj, 10, 2023
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