3AB2
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![BU of 3ab2 by Molmil](/molmil-images/mine/3ab2) | Crystal structure of aspartate kinase from Corynebacterium glutamicum in complex with threonine | Descriptor: | Aspartokinase, THREONINE | Authors: | Yoshida, A, Tomita, T, Kuzuyama, T, Nishiyama, M. | Deposit date: | 2009-11-30 | Release date: | 2010-06-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Mechanism of concerted inhibition of {alpha}2{beta}2-type heterooligomeric aspartate kinase from Corynebacterium glutamicum J.Biol.Chem., 285, 2010
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2AOT
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![BU of 2aot by Molmil](/molmil-images/mine/2aot) | Histamine Methyltransferase Complexed with the Antihistamine Drug Diphenhydramine | Descriptor: | Histamine N-methyltransferase, N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Horton, J.R, Sawada, K, Nishibori, M, Cheng, X. | Deposit date: | 2005-08-14 | Release date: | 2005-09-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for inhibition of histamine N-methyltransferase by diverse drugs J.Mol.Biol., 353, 2005
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2AOW
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![BU of 2aow by Molmil](/molmil-images/mine/2aow) | Histamine Methyltransferase (Natural Variant I105) Complexed with the Acetylcholinesterase Inhibitor and Altzheimer's Disease Drug Tacrine | Descriptor: | Histamine N-methyltransferase, TACRINE | Authors: | Horton, J.R, Sawada, K, Nishibori, M, Cheng, X. | Deposit date: | 2005-08-14 | Release date: | 2005-09-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.97 Å) | Cite: | Structural basis for inhibition of histamine N-methyltransferase by diverse drugs J.Mol.Biol., 353, 2005
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2AOX
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![BU of 2aox by Molmil](/molmil-images/mine/2aox) | Histamine Methyltransferase (Primary Variant T105) Complexed with the Acetylcholinesterase Inhibitor and Altzheimer's Disease Drug Tacrine | Descriptor: | Histamine N-methyltransferase, TACRINE | Authors: | Horton, J.R, Sawada, K, Nishibori, M, Cheng, X. | Deposit date: | 2005-08-14 | Release date: | 2005-09-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.12 Å) | Cite: | Structural basis for inhibition of histamine N-methyltransferase by diverse drugs J.Mol.Biol., 353, 2005
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2AOV
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![BU of 2aov by Molmil](/molmil-images/mine/2aov) | Histamine Methyltransferase Complexed with the Antifolate Drug Metoprine | Descriptor: | 4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE, 5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE-2,4-DIAMINE, Histamine N-methyltransferase | Authors: | Horton, J.R, Sawada, K, Nishibori, M, Cheng, X. | Deposit date: | 2005-08-14 | Release date: | 2005-09-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Structural basis for inhibition of histamine N-methyltransferase by diverse drugs J.Mol.Biol., 353, 2005
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3AH3
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![BU of 3ah3 by Molmil](/molmil-images/mine/3ah3) | Crystal structure of LR5-1, 3-isopropylmalate dehydrogenase created by directed evolution | Descriptor: | 1,2-ETHANEDIOL, Homoisocitrate dehydrogenase, SULFATE ION | Authors: | Tomita, T, Suzuki, Y, Kuzuyama, T, Nishiyama, M. | Deposit date: | 2010-04-13 | Release date: | 2011-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Enhancement of the latent 3-isopropylmalate dehydrogenase activity of promiscuous homoisocitrate dehydrogenase by directed evolution Biochem.J., 431, 2010
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5GUC
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![BU of 5guc by Molmil](/molmil-images/mine/5guc) | Crystal structure of CotB2 (apo form) from Streptomyces melanosporofaciens | Descriptor: | Cyclooctat-9-en-7-ol synthase, FORMIC ACID | Authors: | Tomita, T, Kim, S.-Y, Ozaki, T, Yoshida, A, Kuzuyama, T, Nishiyama, M. | Deposit date: | 2016-08-28 | Release date: | 2017-06-07 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol ACS Chem. Biol., 12, 2017
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2AOU
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![BU of 2aou by Molmil](/molmil-images/mine/2aou) | Histamine Methyltransferase Complexed with the Antimalarial Drug Amodiaquine | Descriptor: | 4-[(7-CHLOROQUINOLIN-4-YL)AMINO]-2-[(DIETHYLAMINO)METHYL]PHENOL, Histamine N-methyltransferase | Authors: | Horton, J.R, Sawada, K, Nishibori, M, Cheng, X. | Deposit date: | 2005-08-14 | Release date: | 2005-09-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for inhibition of histamine N-methyltransferase by diverse drugs J.Mol.Biol., 353, 2005
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1JQD
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![BU of 1jqd by Molmil](/molmil-images/mine/1jqd) | Crystal Structure Analysis of Human Histamine Methyltransferase (Thr105 Polymorphic Variant) Complexed with AdoHcy and Histamine | Descriptor: | HISTAMINE, Histamine N-Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Horton, J.R, Sawada, K, Nishibori, M, Zhang, X, Cheng, X. | Deposit date: | 2001-08-06 | Release date: | 2002-08-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons. Structure, 9, 2001
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3WFZ
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![BU of 3wfz by Molmil](/molmil-images/mine/3wfz) | Crystal structure of Galacto-N-Biose/Lacto-N-Biose I Phosphorylase C236Y Mutant | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, Lacto-N-biose phosphorylase | Authors: | Koyama, Y, Hidaka, M, Kawakami, M, Nishimoto, M, Kitaoka, M. | Deposit date: | 2013-07-25 | Release date: | 2013-10-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Directed evolution to enhance thermostability of galacto-N-biose/lacto-N-biose I phosphorylase. Protein Eng.Des.Sel., 26, 2013
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3AWI
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![BU of 3awi by Molmil](/molmil-images/mine/3awi) | Bifunctional tRNA modification enzyme MnmC from Escherichia coli | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein mnmC | Authors: | Kitamura, A, Sengoku, T, Nishimoto, M, Yokoyama, S, Bessho, Y. | Deposit date: | 2011-03-23 | Release date: | 2011-06-01 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the bifunctional tRNA modification enzyme MnmC from Escherichia coli Protein Sci., 2011
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1UC5
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![BU of 1uc5 by Molmil](/molmil-images/mine/1uc5) | Structure of diol dehydratase complexed with (R)-1,2-propanediol | Descriptor: | AMMONIUM ION, CYANOCOBALAMIN, POTASSIUM ION, ... | Authors: | Shibata, N, Nakanishi, Y, Fukuoka, M, Yamanishi, M, Yasuoka, N, Toraya, T. | Deposit date: | 2003-04-08 | Release date: | 2003-07-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural rationalization for the lack of stereospecificity in coenzyme B12-dependent diol dehydratase J.Biol.Chem., 278, 2003
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1UC4
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![BU of 1uc4 by Molmil](/molmil-images/mine/1uc4) | Structure of diol dehydratase complexed with (S)-1,2-propanediol | Descriptor: | AMMONIUM ION, CYANOCOBALAMIN, POTASSIUM ION, ... | Authors: | Shibata, N, Nakanishi, Y, Fukuoka, M, Yamanishi, M, Yasuoka, N, Toraya, T. | Deposit date: | 2003-04-08 | Release date: | 2003-07-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural rationalization for the lack of stereospecificity in coenzyme B12-dependent diol dehydratase J.BIOL.CHEM., 278, 2003
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7WUW
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![BU of 7wuw by Molmil](/molmil-images/mine/7wuw) | Crystal structure of AziU3/U2 from Streptomyces sahachiroi | Descriptor: | AziU2, AziU3, MAGNESIUM ION, ... | Authors: | Kurosawa, S, Yoshida, A, Tomita, T, Nishiyama, M. | Deposit date: | 2022-02-09 | Release date: | 2022-09-07 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Molecular Basis for Enzymatic Aziridine Formation via Sulfate Elimination. J.Am.Chem.Soc., 144, 2022
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5B1Q
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![BU of 5b1q by Molmil](/molmil-images/mine/5b1q) | Human herpesvirus 6B tegument protein U14 | Descriptor: | GLYCEROL, U14 protein | Authors: | Wang, B, Nishimura, M, Tang, H, Kawabata, A, Mahmoud, N.F, Khanlari, Z, Hamada, D, Tsuruta, H, Mori, Y. | Deposit date: | 2015-12-11 | Release date: | 2016-04-20 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal Structure of Human Herpesvirus 6B Tegument Protein U14. Plos Pathog., 12, 2016
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1ZRN
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![BU of 1zrn by Molmil](/molmil-images/mine/1zrn) | INTERMEDIATE STRUCTURE OF L-2-HALOACID DEHALOGENASE WITH MONOCHLOROACETATE | Descriptor: | ACETIC ACID, L-2-HALOACID DEHALOGENASE | Authors: | Li, Y.-F, Hata, Y, Fujii, T, Hisano, T, Nishihara, M, Kurihara, T, Esaki, N. | Deposit date: | 1998-03-03 | Release date: | 1999-03-23 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Crystal structures of reaction intermediates of L-2-haloacid dehalogenase and implications for the reaction mechanism. J.Biol.Chem., 273, 1998
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5XOY
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![BU of 5xoy by Molmil](/molmil-images/mine/5xoy) | Crystal structure of LysK from Thermus thermophilus in complex with Lysine | Descriptor: | LYSINE, SULFATE ION, [LysW]-lysine hydrolase | Authors: | Tomita, T, Fujita, S, Hasebe, F, Cho, S.-H, Yoshida, A, Kuzuyama, T, Nishiyama, M. | Deposit date: | 2017-05-31 | Release date: | 2017-09-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Crystal structure of LysK, an enzyme catalyzing the last step of lysine biosynthesis in Thermus thermophilus, in complex with lysine: Insight into the mechanism for recognition of the amino-group carrier protein, LysW Biochem. Biophys. Res. Commun., 491, 2017
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1ZRM
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![BU of 1zrm by Molmil](/molmil-images/mine/1zrm) | CRYSTAL STRUCTURE OF THE REACTION INTERMEDIATE OF L-2-HALOACID DEHALOGENASE WITH 2-CHLORO-N-BUTYRATE | Descriptor: | L-2-HALOACID DEHALOGENASE, butanoic acid | Authors: | Li, Y.-F, Hata, Y, Fujii, T, Hisano, T, Nishihara, M, Kurihara, T, Esaki, N. | Deposit date: | 1998-03-03 | Release date: | 1999-03-23 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of reaction intermediates of L-2-haloacid dehalogenase and implications for the reaction mechanism. J.Biol.Chem., 273, 1998
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7Y5Y
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![BU of 7y5y by Molmil](/molmil-images/mine/7y5y) | X-ray Structure of Stay-Green (SGR) from Anaerolineae bacterium. | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, ... | Authors: | Dey, D, Nishijima, M, Kurisu, G, Tanaka, H, Ito, H. | Deposit date: | 2022-06-18 | Release date: | 2022-10-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure and reaction mechanism of a bacterial Mg-dechelatase homolog from the Chloroflexi Anaerolineae. Protein Sci., 31, 2022
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2ZP7
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![BU of 2zp7 by Molmil](/molmil-images/mine/2zp7) | Crystal structure of LysN, alpha-aminoadipate aminotransferase (Leucine complex), from Thermus thermophilus HB27 | Descriptor: | Alpha-aminodipate aminotransferase, LEUCINE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Tomita, T, Miyazaki, T, Miyagawa, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. | Deposit date: | 2008-06-30 | Release date: | 2009-01-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Mechanism for multiple-substrates recognition of alpha-aminoadipate aminotransferase from Thermus thermophilus Proteins, 2008
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3AAW
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![BU of 3aaw by Molmil](/molmil-images/mine/3aaw) | Crystal structure of aspartate kinase from Corynebacterium glutamicum in complex with lysine and threonine | Descriptor: | Aspartokinase, Aspartokinase LysC beta subunit, LYSINE, ... | Authors: | Yoshida, A, Tomita, T, Kuzuyama, T, Nishiyama, M. | Deposit date: | 2009-11-27 | Release date: | 2010-06-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanism of concerted inhibition of {alpha}2{beta}2-type heterooligomeric aspartate kinase from Corynebacterium glutamicum J.Biol.Chem., 285, 2010
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3AOE
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![BU of 3aoe by Molmil](/molmil-images/mine/3aoe) | |
3AOG
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![BU of 3aog by Molmil](/molmil-images/mine/3aog) | |
2CZL
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![BU of 2czl by Molmil](/molmil-images/mine/2czl) | Crystal structure of MqnD (TTHA1568), a menaquinone biosynthetic enzyme from Thermus thermophilus HB8 (Cys11 modified with beta-mercaptoethanol) | Descriptor: | 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, L(+)-TARTARIC ACID, POTASSIUM ION, ... | Authors: | Arai, R, Nishino, A, Nagano, K, Kamo-Uchikubo, T, Nishimoto, M, Toyama, M, Terada, T, Murayama, K, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-07-13 | Release date: | 2006-01-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structure of MqnD (TTHA1568), a menaquinone biosynthetic enzyme from Thermus thermophilus HB8. J.Struct.Biol., 168, 2009
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6K36
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![BU of 6k36 by Molmil](/molmil-images/mine/6k36) | |