4LCU
 
 | | Structure of KcsA with E118A mutation | | 分子名称: | DIACYL GLYCEROL, Fab heavy chain, Fab light chain, ... | | 著者 | Nimigean, C.M, Posson, D.J, McCoy, J.M. | | 登録日 | 2013-06-23 | | 公開日 | 2013-10-30 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.752 Å) | | 主引用文献 | Molecular interactions involved in proton-dependent gating in KcsA potassium channels.
J.Gen.Physiol., 142, 2013
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4LBE
 | | Structure of KcsA with R122A mutation | | 分子名称: | DIACYL GLYCEROL, Fab heavy chain, Fab light chain, ... | | 著者 | Nimigean, C.M, Posson, D.J, McCoy, J.M. | | 登録日 | 2013-06-20 | | 公開日 | 2013-10-30 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.751 Å) | | 主引用文献 | Molecular interactions involved in proton-dependent gating in KcsA potassium channels.
J.Gen.Physiol., 142, 2013
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6CJU
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6CJQ
 | | Structure of the SthK cyclic nucleotide-gated potassium channel | | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, SthK cyclic nucleotide-gated potassium channel | | 著者 | Nimigean, C.M, Rheinberger, J. | | 登録日 | 2018-02-26 | | 公開日 | 2018-08-01 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | | 主引用文献 | Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures.
Elife, 7, 2018
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6CJT
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8FZ7
 | | TpeA bound closed MthK-A88F mutant in nanodisc | | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1-(tripentyl-$l^{4}-azanyl)pentane, Calcium-gated potassium channel MthK, ... | | 著者 | Agarwal, S, Nimigean, C.M. | | 登録日 | 2023-01-27 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Calcium-gated potassium channel blockade via membrane-facing fenestrations.
Nat.Chem.Biol., 20, 2024
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9BC6
 | | HCN1 M305L with propofol | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,6-BIS(1-METHYLETHYL)PHENOL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | 著者 | Kim, E.D, Nimigean, C.M. | | 登録日 | 2024-04-07 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
Nature, 632, 2024
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9BC7
 | | HCN1 M305L holo | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | 著者 | Kim, E.D, Nimigean, C.M. | | 登録日 | 2024-04-08 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
Nature, 632, 2024
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3GB7
 | | Potassium Channel KcsA-Fab complex in Li+ | | 分子名称: | DIACYL GLYCEROL, NICKEL (II) ION, Voltage-gated potassium channel, ... | | 著者 | Thompson, A.N, Ilsoo, K, Panosian, T.D, Iverson, T.M, Allen, T.W, Nimigean, C.M. | | 登録日 | 2009-02-18 | | 公開日 | 2009-11-17 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore.
Nat.Struct.Mol.Biol., 16, 2009
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3IGA
 | | Potassium Channel KcsA-Fab complex in Li+ and K+ | | 分子名称: | Antibody Fab Fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | | 著者 | Thompson, A.N, Ilsoo, K, Panosian, T.D, Iverson, T.M, Allen, T.W, Nimigean, C.M. | | 登録日 | 2009-07-27 | | 公開日 | 2009-11-17 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore.
Nat.Struct.Mol.Biol., 16, 2009
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8DE7
 | | Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM detergent | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, POTASSIUM ION, Potassium channel, ... | | 著者 | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | | 登録日 | 2022-06-20 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.
Nat Commun, 14, 2023
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8DE9
 | | Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM/POPE mixed micelles | | 分子名称: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, POTASSIUM ION, Potassium channel, ... | | 著者 | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | | 登録日 | 2022-06-20 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.
Nat Commun, 14, 2023
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8DE8
 | | Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM/POPA mixed micelles | | 分子名称: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, POTASSIUM ION, Potassium channel, ... | | 著者 | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | | 登録日 | 2022-06-20 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | | 主引用文献 | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.
Nat Commun, 14, 2023
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6U5P
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6U68
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6U6E
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6U6D
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6U5N
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6U9P
 | | Wild-type MthK pore in ~150 mM K+ | | 分子名称: | Calcium-gated potassium channel MthK, HEXANE-1,6-DIOL, POTASSIUM ION | | 著者 | Posson, D.J, Nimigean, C.M. | | 登録日 | 2019-09-09 | | 公開日 | 2020-11-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Selectivity filter ion binding affinity determines inactivation in a potassium channel.
Proc.Natl.Acad.Sci.USA, 117, 2020
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8DJB
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3OGC
 | | KcsA E71A variant in presence of Na+ | | 分子名称: | SODIUM ION, Voltage-gated potassium channel, antibody Fab fragment heavy chain, ... | | 著者 | McCoy, J.G, Nimigean, C.M. | | 登録日 | 2010-08-16 | | 公開日 | 2011-03-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Mechanism for selectivity-inactivation coupling in KcsA potassium channels.
Proc.Natl.Acad.Sci.USA, 108, 2011
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5E1A
 | | Structure of KcsA with L24C/R117C mutations | | 分子名称: | POTASSIUM ION, antibody Fab fragment heavy chain, antibody Fab fragment light chain, ... | | 著者 | Upadhyay, V, Kim, D.M, Nimigean, C.M. | | 登録日 | 2015-09-29 | | 公開日 | 2016-07-13 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles.
J.Gen.Physiol., 148, 2016
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4HZ3
 | | MthK pore crystallized in presence of TBSb | | 分子名称: | Calcium-gated potassium channel mthK, HEXANE-1,6-DIOL, POTASSIUM ION | | 著者 | Posson, D.J, McCoy, J.G, Nimigean, C.M. | | 登録日 | 2012-11-14 | | 公開日 | 2012-12-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The voltage-dependent gate in MthK potassium channels is located at the selectivity filter.
Nat.Struct.Mol.Biol., 20, 2013
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4HYO
 | | Crystal Structure of MthK Pore | | 分子名称: | Calcium-gated potassium channel mthK, HEXANE-1,6-DIOL, POTASSIUM ION | | 著者 | Posson, D.J, McCoy, J.G, Nimigean, C.M. | | 登録日 | 2012-11-13 | | 公開日 | 2012-12-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | The voltage-dependent gate in MthK potassium channels is located at the selectivity filter.
Nat.Struct.Mol.Biol., 20, 2013
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4CHW
 | | The electron crystallography structure of the cAMP-free potassium channel MloK1 | | 分子名称: | CYCLIC NUCLEOTIDE-GATED POTASSIUM CHANNEL MLL3241, POTASSIUM ION | | 著者 | Kowal, J, Chami, M, Baumgartner, P, Arheit, M, Chiu, P.L, Rangl, M, Scheuring, S, Schroeder, G.F, Nimigean, C.M, Stahlberg, H. | | 登録日 | 2013-12-04 | | 公開日 | 2014-01-15 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (7 Å) | | 主引用文献 | Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.
Nat Commun, 5, 2014
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