6R3W
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![BU of 6r3w by Molmil](/molmil-images/mine/6r3w) | M.tuberculosis nitrobindin with a water molecule coordinated to the heme iron atom | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, UPF0678 fatty acid-binding protein-like protein ERS007657_00996 | Authors: | De Simone, G, di Masi, A, Polticelli, F, Pesce, A, Nardini, M, Bolognesi, M, Ciaccio, C, Coletta, M, Turilli, E.S, Fasano, M, Tognaccini, L, Smulevich, G, Abbruzzetti, S, Viappiani, C, Bruno, S, Ascenzi, P. | Deposit date: | 2019-03-21 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Mycobacterial and Human Nitrobindins: Structure and Function. Antioxid.Redox Signal., 33, 2020
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6R3Y
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![BU of 6r3y by Molmil](/molmil-images/mine/6r3y) | M.tuberculosis nitrobindin with a cyanide molecule coordinated to the heme iron atom | Descriptor: | CYANIDE ION, PROTOPORPHYRIN IX CONTAINING FE, UPF0678 fatty acid-binding protein-like protein ERS007657_00996 | Authors: | De Simone, G, di Masi, A, Polticelli, F, Pesce, A, Nardini, M, Bolognesi, M, Ciaccio, C, Coletta, M, Turilli, E.S, Fasano, M, Tognaccini, L, Smulevich, G, Abbruzzetti, S, Viappiani, C, Bruno, S, Ascenzi, P. | Deposit date: | 2019-03-21 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Mycobacterial and Human Nitrobindins: Structure and Function. Antioxid.Redox Signal., 33, 2020
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7ZCE
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7ZCF
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![BU of 7zcf by Molmil](/molmil-images/mine/7zcf) | |
5GDS
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![BU of 5gds by Molmil](/molmil-images/mine/5gds) | HIRUNORMS ARE TRUE HIRUDIN MIMETICS. THE CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN:HIRUNORM V COMPLEX | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN, HIRUNORM V | Authors: | De Simone, G, Lombardi, A, Galdiero, S, Nastri, F, Della Morte, R, Staiano, N, Pedone, C, Bolognesi, M, Pavone, V. | Deposit date: | 1997-07-17 | Release date: | 1998-01-21 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex. Protein Sci., 7, 1998
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8OFI
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![BU of 8ofi by Molmil](/molmil-images/mine/8ofi) | Ivabradine bound to HCN4 channel | Descriptor: | Ivabradine, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Authors: | Saponaro, A, Chaves-Sanjuan, A, Sharifzadeh, A.S, Clarke, O.B, Marabelli, C, Bolognesi, M, Thiel, G, Moroni, A. | Deposit date: | 2023-03-15 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural determinants of ivabradine block of the open pore of HCN4. Proc.Natl.Acad.Sci.USA, 121, 2024
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4UIQ
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![BU of 4uiq by Molmil](/molmil-images/mine/4uiq) | Isolated globin domain of the Bordetella pertussis globin-coupled sensor with a heme at the dimer interface | Descriptor: | GLOBIN-COUPLED SENSOR WITH DIGUANYLATE CYCLASE ACTIVITY, GLYCEROL, IMIDAZOLE, ... | Authors: | Germani, F, Donne, J, De Schutter, A, Pesce, A, Berghmans, H, Van Hauwaert, M.-L, Moens, L, Van Doorslaer, S, Bolognesi, M, Nardini, M, Dewilde, S. | Deposit date: | 2015-03-31 | Release date: | 2016-04-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Identification of a Putative Allosteric Site in the Sensor Domain of Bordetella Pertussis Globin- Coupled Sensor for the Control of Biofilm Formation To be Published
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4UII
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![BU of 4uii by Molmil](/molmil-images/mine/4uii) | Crystal structure of the Azotobacter vinelandii globin-coupled oxygen sensor in the aquo-met form | Descriptor: | GGDEF DOMAIN PROTEIN, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Germani, F, De Schutter, A, Pesce, A, Berghmans, H, Van Hauwaert, M.-L, Cuypers, B, Bruno, S, Mozzarelli, A, Moens, L, Van Doorslaer, S, Bolognesi, M, Nardini, M, Dewilde, S. | Deposit date: | 2015-03-30 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.827 Å) | Cite: | Azotobacter Vinelandii Globin-Coupled Oxygen Sensor is a Diguanylate Cyclase with a Biphasic Oxygen Dissociation To be Published
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4UT1
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4UU4
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![BU of 4uu4 by Molmil](/molmil-images/mine/4uu4) | Crystal structure of LptH, the LptA homologous periplasmic component of the conserved lipopolysaccharide transport device from Pseudomonas aeruginosa | Descriptor: | PERIPLASMIC LIPOPOLYSACCHARIDE TRANSPORT PROTEIN LPTH | Authors: | Bollati, M, Villa, R, Gourlay, L.J, Barbiroli, A, Deho, G, Benedet, M, Polissi, A, Martorana, A, Sperandeo, P, Bolognesi, M, Nardini, M. | Deposit date: | 2014-07-24 | Release date: | 2015-03-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.751 Å) | Cite: | Crystal Structure of Lpth, the Periplasmic Component of the Lipopolysaccharide Transport Machinery from Pseudomonas Aeruginosa. FEBS J., 282, 2015
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6Q6P
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![BU of 6q6p by Molmil](/molmil-images/mine/6q6p) | Antarctic fish cytoglobin 1 from D.mawsoni | Descriptor: | Cytoglobin, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Giordano, D, Pesce, A, Vermeylen, S, Abbruzzetti, S, Nardini, M, Marchesani, F, Berghmans, H, Seira, C, Bruno, S, Luque, F.J, di Prisco, G, Ascenzi, P, Dewilde, S, Bolognesi, M, Viappiani, C, Verde, C. | Deposit date: | 2018-12-11 | Release date: | 2020-01-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural and functional properties of Antarctic fish cytoglobins-1: Cold-reactivity in multi-ligand reactions. Comput Struct Biotechnol J, 18, 2020
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9FGU
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![BU of 9fgu by Molmil](/molmil-images/mine/9fgu) | SARS-CoV-2 (B.1.1.529/Omicron variant) Spike protein in complex with the single chain fragment scFv76-77 (focused refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin, scFv76-77 single chain fragment | Authors: | Berlinguer, M, Chaves-Sanjuan, A, Milazzo, F.M, Minenkova, O, De Santis, R, Bolognesi, M. | Deposit date: | 2024-05-25 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structure of scFv76-77 in complex with SARS-CoV-2 Omicron Spike protein To Be Published
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9FGT
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![BU of 9fgt by Molmil](/molmil-images/mine/9fgt) | SARS-CoV-2 (B.1.1.529/Omicron variant) Spike protein in complex with the single chain fragment scFv76 (focused refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Single chain fragment scFv76, Spike glycoprotein,Fibritin | Authors: | Berlinguer, M, Chaves-Sanjuan, A, Milazzo, F.M, Minenkova, O, De Santis, R, Bolognesi, M. | Deposit date: | 2024-05-25 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of scFv76 in complex with SARS-CoV-2 Omicron Spike protein To Be Published
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9FGS
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![BU of 9fgs by Molmil](/molmil-images/mine/9fgs) | SARS-CoV-2 (wuhan variant) Spike protein in complex with the single chain fragment scFv41N (focused refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Single Chain fragment scFv41N, Spike glycoprotein,Fibritin | Authors: | Berlinguer, M, Chaves-Sanjuan, A, Milazzo, F.M, Minenkova, O, De Santis, R, Bolognesi, M. | Deposit date: | 2024-05-25 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of scFv41N in complex with SARS-CoV-2 Spike protein To Be Published
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9FGR
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![BU of 9fgr by Molmil](/molmil-images/mine/9fgr) | SARS-CoV-2 (wuhan variant) Spike protein in complex with the single chain fragment scFv76-77 (focused refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, scFv76-77 single chain fragment | Authors: | Berlinguer, M, Chaves-Sanjuan, A, Milazzo, F.M, Minenkova, O, De Santis, R, Bolognesi, M. | Deposit date: | 2024-05-25 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of scFv76-77 in complex with SARS-CoV-2 Spike protein To Be Published
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6S6U
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6S6X
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![BU of 6s6x by Molmil](/molmil-images/mine/6s6x) | Structure of Azospirillum brasilense Glutamate Synthase in a6b6 oligomeric state. | Descriptor: | FE3-S4 CLUSTER, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Chaves-Sanjuan, A, Camilloni, C, Bolognesi, M. | Deposit date: | 2019-07-03 | Release date: | 2019-09-11 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM Structures of Azospirillum brasilense Glutamate Synthase in Its Oligomeric Assemblies. J.Mol.Biol., 431, 2019
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6S6T
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5FAE
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![BU of 5fae by Molmil](/molmil-images/mine/5fae) | N184K pathological variant of gelsolin domain 2 (trigonal form) | Descriptor: | CALCIUM ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Boni, F, Milani, M, Ricagno, S, Bolognesi, M, de Rosa, M. | Deposit date: | 2015-12-11 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant. Sci Rep, 6, 2016
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5FAF
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![BU of 5faf by Molmil](/molmil-images/mine/5faf) | N184K pathological variant of gelsolin domain 2 (orthorhombic form) | Descriptor: | ACETATE ION, CALCIUM ION, CHLORIDE ION, ... | Authors: | Boni, F, Milani, M, Ricagno, s, Bolognesi, M, de Rosa, M. | Deposit date: | 2015-12-11 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant. Sci Rep, 6, 2016
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6S6S
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![BU of 6s6s by Molmil](/molmil-images/mine/6s6s) | |
5OLU
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![BU of 5olu by Molmil](/molmil-images/mine/5olu) | The crystal structure of a highly thermostable carboxyl esterase from Bacillus coagulans in complex with glycerol | Descriptor: | ACETATE ION, Alpha/beta hydrolase family protein, CHLORIDE ION, ... | Authors: | Gourlay, L.J, Nakhnoukh, C, Bolognesi, M. | Deposit date: | 2017-07-28 | Release date: | 2017-12-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A stereospecific carboxyl esterase from Bacillus coagulans hosting nonlipase activity within a lipase-like fold. FEBS J., 285, 2018
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6TV0
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![BU of 6tv0 by Molmil](/molmil-images/mine/6tv0) | Serratia spp. cyanase hydratase | Descriptor: | Cyanate hydratase, GLYCEROL, OXALIC ACID | Authors: | Pederzoli, R, Tarantino, D, Gourlay, L.J, Chaves-Sanjuan, A, Bolognesi, M. | Deposit date: | 2020-01-08 | Release date: | 2021-01-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Detecting the nature and solving the crystal structure of a contaminant protein from an opportunistic pathogen. Acta Crystallogr.,Sect.F, 76, 2020
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7BGC
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![BU of 7bgc by Molmil](/molmil-images/mine/7bgc) | human butyrylcholinesterase in complex with a tacrine-methylanacardate hybrid inhibitor | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Nachon, F, Salerno, A, Bolognesi, M.L. | Deposit date: | 2021-01-06 | Release date: | 2021-04-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease. J.Med.Chem., 64, 2021
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2Z9T
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![BU of 2z9t by Molmil](/molmil-images/mine/2z9t) | Crystal structure of the human beta-2 microglobulin mutant W60G | Descriptor: | Beta-2-microglobulin | Authors: | Ricagno, S, Bolognesi, M, Bellotti, V, Corazza, A, Rennella, E, Gural, D, Mimmi, M.C, Betto, E, Pucillo, C, Fogolari, F, Viglino, P, Raimondi, S, Giorgetti, S, Bolognesi, B, Merlini, G, Stoppini, M. | Deposit date: | 2007-09-26 | Release date: | 2008-04-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties J.Mol.Biol., 378, 2008
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